SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4s3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 CYH C  42
ARG B  26
CYH C  21
 ZN  C 201 (-2.2A)
ZN  C 201 ( 4.7A)
ZN  C 201 (-2.2A)
 1.40A 1p9gA-4s3oC:
undetectable		 1p9gA-4s3oC:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG C  55
ASP C  72
ASN B 105
 None
 0.86A 2zzmA-4s3oC:
undetectable		 2zzmA-4s3oC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5
(Homo
sapiens) 		6 / 12 LEU B  45
LEU B  49
ILE B 113
ASN B 105
PHE B 106
LEU C  82
 None
 1.35A 4lmnA-4s3oB:
undetectable		 4lmnA-4s3oB:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
POLYCOMB GROUP RING
FINGER PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU C  82
LEU B  45
LEU B  49
PHE B 106
PRO C  28
 None
 1.01A 4odrA-4s3oC:
undetectable
4odrB-4s3oC:
undetectable		 4odrA-4s3oC:
23.26
4odrB-4s3oC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4s3o E3 UBIQUITIN-PROTEIN
LIGASE RING2
(Homo
sapiens) 		3 / 3 LYS B  59
ASP B 107
ILE B  53
 None
 0.79A 5kc4E-4s3oB:
undetectable		 5kc4E-4s3oB:
20.44