SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4sli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.06A 1a4gA-4sliA:
24.8		 1a4gA-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 1a4gA-4sliA:
24.8		 1a4gA-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.06A 1a4gB-4sliA:
24.6		 1a4gB-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 1a4gB-4sliA:
24.6		 1a4gB-4sliA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 TYR A 582
ASP A 586
GLY A 591
LEU A 610
ALA A 585
 None
 1.11A 1e3vA-4sliA:
undetectable		 1e3vA-4sliA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 TYR A 582
ASP A 586
GLY A 591
LEU A 610
ALA A 585
 None
 1.05A 1e3vB-4sliA:
undetectable		 1e3vB-4sliA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 VAL A 526
ILE A 525
TYR A 457
ILE A 434
PHE A 409
 None
 1.39A 1fkjA-4sliA:
undetectable		 1fkjA-4sliA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.96A 1nncA-4sliA:
21.1		 1nncA-4sliA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 1nncA-4sliA:
21.1		 1nncA-4sliA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
ARG A 673
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
 0.82A 1v3eA-4sliA:
25.4		 1v3eA-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_A_ZMRA1200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.92A 1v3eA-4sliA:
25.4		 1v3eA-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3E_B_ZMRB2200_1
(HEMAGGLUTININ-NEURAM
INIDASE GLYCOPROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ARG A 293
TYR A 561
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.78A 1v3eB-4sliA:
25.2		 1v3eB-4sliA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 PHE A 248
ALA A 245
ILE A  94
ILE A 252
THR A 234
 None
 1.28A 2bjfA-4sliA:
undetectable		 2bjfA-4sliA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 2cmlA-4sliA:
4.8		 2cmlA-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.59A 2cmlA-4sliA:
4.8		 2cmlA-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 2cmlB-4sliA:
5.8		 2cmlB-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.59A 2cmlB-4sliA:
5.8		 2cmlB-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.01A 2cmlC-4sliA:
4.0		 2cmlC-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 2cmlC-4sliA:
4.0		 2cmlC-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.07A 2cmlD-4sliA:
21.3		 2cmlD-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 2cmlD-4sliA:
21.3		 2cmlD-4sliA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
TYR A 561
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.45A 2f0zA-4sliA:
39.6		 2f0zA-4sliA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		8 / 12 ARG A 293
ILE A 294
ARG A 312
TYR A 561
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
CNP  A 760 (-3.6A)
None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 2f10A-4sliA:
38.4		 2f10A-4sliA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 VAL A 526
ILE A 525
TYR A 457
ILE A 434
PHE A 409
 None
 1.39A 2fkeA-4sliA:
undetectable		 2fkeA-4sliA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.22A 2htqA-4sliA:
10.9		 2htqA-4sliA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.76A 2htqA-4sliA:
10.9		 2htqA-4sliA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 ASP A 198
ASP A 217
THR A 215
ASP A 264
 None
 1.10A 2j2pE-4sliA:
undetectable
2j2pF-4sliA:
undetectable		 2j2pE-4sliA:
15.27
2j2pF-4sliA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 LEU A 739
ASN A 364
ARG A 736
 None
 0.99A 2qhfA-4sliA:
undetectable		 2qhfA-4sliA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ASN A 737
ASP A 310
ILE A 323
ILE A 374
ASP A 318
 None
None
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.6A)
 1.33A 2qmjA-4sliA:
undetectable		 2qmjA-4sliA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 ILE A  94
LEU A 121
ILE A 252
ILE A 153
PHE A 248
 None
 0.98A 2w9sA-4sliA:
undetectable		 2w9sA-4sliA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 ILE A  94
LEU A 121
ILE A 252
ILE A 153
PHE A 248
 None
 0.97A 2w9sB-4sliA:
undetectable		 2w9sB-4sliA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.28A 2ya7A-4sliA:
46.1		 2ya7A-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.42A 2ya7A-4sliA:
46.1		 2ya7A-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.25A 2ya7B-4sliA:
45.8		 2ya7B-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7B-4sliA:
45.8		 2ya7B-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.25A 2ya7C-4sliA:
41.1		 2ya7C-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7C-4sliA:
41.1		 2ya7C-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 323
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
None
CNP  A 760 (-3.0A)
 1.24A 2ya7D-4sliA:
45.1		 2ya7D-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		10 / 12 ARG A 293
ILE A 294
ASP A 310
ILE A 374
ASP A 375
ASP A 392
TYR A 561
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
None
CNP  A 760 ( 4.4A)
CNP  A 760 (-2.8A)
CNP  A 760 (-4.4A)
None
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.41A 2ya7D-4sliA:
45.1		 2ya7D-4sliA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ASN A 324
GLY A 314
TYR A 313
ASN A 353
ARG A 358
 None
 1.44A 2zvjA-4sliA:
undetectable		 2zvjA-4sliA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 3b7eA-4sliA:
21.6		 3b7eA-4sliA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.66A 3b7eB-4sliA:
12.7		 3b7eB-4sliA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 VAL A 583
GLY A 569
THR A 608
ILE A 598
LEU A 557
 None
 1.19A 3bf1A-4sliA:
undetectable
3bf1B-4sliA:
undetectable		 3bf1A-4sliA:
16.96
3bf1B-4sliA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 LEU A 557
VAL A 583
GLY A 569
THR A 608
ILE A 598
 None
 1.20A 3bf1A-4sliA:
undetectable
3bf1B-4sliA:
undetectable		 3bf1A-4sliA:
16.96
3bf1B-4sliA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 3ckzA-4sliA:
12.6		 3ckzA-4sliA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ILE A 398
SER A 370
SER A 321
LYS A 320
GLY A 397
 None
 1.27A 3ik6B-4sliA:
undetectable
3ik6E-4sliA:
undetectable		 3ik6B-4sliA:
17.60
3ik6E-4sliA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 10 ILE A 398
SER A 370
SER A 321
LYS A 320
GLY A 397
 None
 1.23A 3ik6B-4sliA:
undetectable
3ik6E-4sliA:
undetectable		 3ik6B-4sliA:
17.60
3ik6E-4sliA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 ILE A 398
SER A 370
SER A 321
LYS A 320
GLY A 397
 None
 1.19A 3iluB-4sliA:
undetectable
3iluE-4sliA:
undetectable		 3iluB-4sliA:
17.60
3iluE-4sliA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
 0.61A 3k37B-4sliA:
24.7		 3k37B-4sliA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.53A 3k39B-4sliA:
24.6		 3k39B-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.14A 3k39N-4sliA:
24.6		 3k39N-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_P_BCZP1001_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.14A 3k39P-4sliA:
24.7		 3k39P-4sliA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 TYR A 507
LEU A 523
TYR A 457
TYR A 373
 None
 1.17A 3po7A-4sliA:
undetectable		 3po7A-4sliA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 3sanA-4sliA:
2.5		 3sanA-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 3sanA-4sliA:
2.5		 3sanA-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 3sanB-4sliA:
10.9		 3sanB-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 3sanB-4sliA:
10.9		 3sanB-4sliA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.63A 3ti5A-4sliA:
12.2		 3ti5A-4sliA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 3ti5B-4sliA:
21.5		 3ti5B-4sliA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 3ticA-4sliA:
8.3		 3ticA-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 3ticA-4sliA:
8.3		 3ticA-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 3ticB-4sliA:
21.6		 3ticB-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 3ticB-4sliA:
21.6		 3ticB-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.04A 3ticC-4sliA:
8.0		 3ticC-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 3ticC-4sliA:
8.0		 3ticC-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.03A 3ticD-4sliA:
21.4		 3ticD-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 3ticD-4sliA:
21.4		 3ticD-4sliA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 VAL A 526
ILE A 525
TYR A 457
ILE A 434
PHE A 409
 None
 1.42A 3vawA-4sliA:
undetectable		 3vawA-4sliA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 GLY A 237
TYR A 152
TYR A 246
GLU A 162
 None
 0.98A 4ae1A-4sliA:
undetectable		 4ae1A-4sliA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4b7nA-4sliA:
12.3		 4b7nA-4sliA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 4b7qA-4sliA:
10.9		 4b7qA-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.69A 4b7qB-4sliA:
21.4		 4b7qB-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.64A 4b7qC-4sliA:
12.1		 4b7qC-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.69A 4b7qD-4sliA:
21.7		 4b7qD-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.12A 4cpnA-4sliA:
24.6		 4cpnA-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4cpnA-4sliA:
24.6		 4cpnA-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.08A 4cpnB-4sliA:
4.0		 4cpnB-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpnB-4sliA:
4.0		 4cpnB-4sliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.16A 4cpzA-4sliA:
4.1		 4cpzA-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 4cpzA-4sliA:
4.1		 4cpzA-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.10A 4cpzB-4sliA:
24.8		 4cpzB-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 4cpzB-4sliA:
24.8		 4cpzB-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.12A 4cpzC-4sliA:
24.8		 4cpzC-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpzC-4sliA:
24.8		 4cpzC-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.08A 4cpzD-4sliA:
25.0		 4cpzD-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.53A 4cpzD-4sliA:
25.0		 4cpzD-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.13A 4cpzE-4sliA:
24.8		 4cpzE-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.62A 4cpzE-4sliA:
24.8		 4cpzE-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.17A 4cpzF-4sliA:
24.8		 4cpzF-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.65A 4cpzF-4sliA:
24.8		 4cpzF-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.15A 4cpzG-4sliA:
24.9		 4cpzG-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 4cpzG-4sliA:
24.9		 4cpzG-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.15A 4cpzH-4sliA:
24.7		 4cpzH-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.67A 4cpzH-4sliA:
24.7		 4cpzH-4sliA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.21A 4feuF-4sliA:
undetectable		 4feuF-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 7 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.21A 4fevD-4sliA:
undetectable		 4fevD-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.19A 4fewD-4sliA:
undetectable		 4fewD-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.17A 4fewF-4sliA:
undetectable		 4fewF-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 7 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.20A 4fexB-4sliA:
undetectable		 4fexB-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 7 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.18A 4gkhG-4sliA:
undetectable		 4gkhG-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 ASP A 198
ASN A 260
GLU A  83
GLU A 266
 None
 1.18A 4gkiA-4sliA:
undetectable		 4gkiA-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 ASP A 198
ARG A 205
ASN A 260
GLU A  83
GLU A 266
 None
 1.41A 4gkiC-4sliA:
undetectable
4gkiD-4sliA:
1.6		 4gkiC-4sliA:
18.35
4gkiD-4sliA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.02A 4i00A-4sliA:
21.6		 4i00A-4sliA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 4i00A-4sliA:
21.6		 4i00A-4sliA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 7 ARG A 428
VAL A 405
PHE A 503
GLU A 532
 None
 1.46A 4jseA-4sliA:
undetectable
4jseB-4sliA:
undetectable		 4jseA-4sliA:
21.54
4jseB-4sliA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 7 PHE A 503
GLU A 532
ARG A 428
VAL A 405
 None
 1.41A 4jseA-4sliA:
undetectable
4jseB-4sliA:
undetectable		 4jseA-4sliA:
21.54
4jseB-4sliA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 5 ILE A 440
ASN A 458
TYR A 457
ILE A 434
 None
 1.05A 4jtpA-4sliA:
undetectable		 4jtpA-4sliA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 SER A 319
SER A 372
ILE A 325
ASP A 310
ILE A 323
 None
 1.33A 4ktvA-4sliA:
undetectable
4ktvB-4sliA:
undetectable		 4ktvA-4sliA:
23.09
4ktvB-4sliA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 11 TYR A 728
VAL A 704
ILE A 678
SER A 665
LEU A 755
 None
 1.33A 4lhmA-4sliA:
undetectable		 4lhmA-4sliA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.95A 4mwrA-4sliA:
7.9		 4mwrA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 4mwrA-4sliA:
7.9		 4mwrA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.61A 4mwxA-4sliA:
7.8		 4mwxA-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ARG A 293
ASP A 318
ARG A 673
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 (-3.0A)
 0.45A 4mx0A-4sliA:
7.2		 4mx0A-4sliA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 5 ILE A 663
LEU A 716
GLU A 718
VAL A 305
 None
 1.02A 4nkxB-4sliA:
undetectable		 4nkxB-4sliA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 VAL A 583
GLY A 569
THR A 608
ILE A 598
LEU A 557
 None
 1.28A 4o5fA-4sliA:
undetectable
4o5fB-4sliA:
undetectable		 4o5fA-4sliA:
18.40
4o5fB-4sliA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 LEU A 557
VAL A 583
GLY A 569
THR A 608
ILE A 598
 None
 1.29A 4o5fA-4sliA:
undetectable
4o5fB-4sliA:
undetectable		 4o5fA-4sliA:
18.40
4o5fB-4sliA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 SER A 125
GLY A 250
ALA A 245
GLY A 237
TYR A 246
 None
 1.25A 4r29A-4sliA:
undetectable		 4r29A-4sliA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 1.07A 4wa5A-4sliA:
13.1		 4wa5A-4sliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.72A 4wa5A-4sliA:
13.1		 4wa5A-4sliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 4 ASN A 675
SER A 701
ALA A 703
VAL A 704
 None
 1.37A 4x1kC-4sliA:
undetectable		 4x1kC-4sliA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 GLY A 725
LEU A 378
PHE A 327
GLY A 517
LEU A 300
 None
 1.15A 4ze1A-4sliA:
undetectable		 4ze1A-4sliA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ASP A 732
ARG A 673
TYR A 731
 None
CNP  A 760 (-3.0A)
None
 0.96A 5a7mA-4sliA:
undetectable		 5a7mA-4sliA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ASP A 732
ARG A 673
TYR A 731
 None
CNP  A 760 (-3.0A)
None
 0.95A 5a7mB-4sliA:
undetectable		 5a7mB-4sliA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 VAL A 583
GLY A 569
THR A 608
ILE A 598
LEU A 557
 None
 1.29A 5b8hA-4sliA:
undetectable
5b8hB-4sliA:
undetectable		 5b8hA-4sliA:
18.63
5b8hB-4sliA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
ALA A 594
LEU A 610
GLY A 613
SER A 614
 None
 1.30A 5jglA-4sliA:
undetectable		 5jglA-4sliA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 VAL A 724
LEU A 647
SER A 665
ILE A 617
 None
 1.03A 5jw1A-4sliA:
undetectable		 5jw1A-4sliA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 ASP A 732
ASN A 155
GLN A 708
 None
 0.79A 5k7uA-4sliA:
undetectable		 5k7uA-4sliA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 9 ALA A 391
ILE A 294
GLY A 542
ILE A 543
ILE A 325
 None
CNP  A 760 (-4.5A)
None
None
None
 1.12A 5kr0A-4sliA:
undetectable		 5kr0A-4sliA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ALA A 592
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 None
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.96A 5l17A-4sliA:
21.3		 5l17A-4sliA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ARG A 293
ASP A 318
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.57A 5l17A-4sliA:
21.3		 5l17A-4sliA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 8 SER A 319
SER A 321
ALA A 311
SER A 289
 None
 1.04A 5l5fY-4sliA:
undetectable
5l5fZ-4sliA:
undetectable		 5l5fY-4sliA:
16.33
5l5fZ-4sliA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 VAL A 193
LYS A 256
MET A  87
 None
 0.95A 5nknA-4sliA:
undetectable		 5nknA-4sliA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 4 ASN A 675
SER A 701
ALA A 703
VAL A 704
 None
 1.23A 5nm5A-4sliA:
undetectable		 5nm5A-4sliA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		3 / 3 TYR A 750
ALA A 703
TYR A 702
 None
 0.87A 5uunB-4sliA:
undetectable		 5uunB-4sliA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.14A 5x7pA-4sliA:
4.1		 5x7pA-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.18A 5x7pB-4sliA:
3.1		 5x7pB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_A_ACRA1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.18A 5x7qA-4sliA:
4.0		 5x7qA-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Q_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.16A 5x7qB-4sliA:
3.0		 5x7qB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7R_B_ACRB1481_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 714
ARG A 293
GLU A 729
TYR A 713
 None
CNP  A 760 (-3.0A)
None
CNP  A 760 (-4.0A)
 1.19A 5x7rB-4sliA:
3.0		 5x7rB-4sliA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 TYR A 495
LEU A 344
GLU A 456
LEU A 523
 None
 1.17A 5xooA-4sliA:
undetectable		 5xooA-4sliA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 SER A 666
GLU A 729
ARG A 312
ASP A 310
 None
None
CNP  A 760 (-3.6A)
None
 1.24A 5zw4A-4sliA:
undetectable		 5zw4A-4sliA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		7 / 12 ARG A 293
ILE A 294
ARG A 312
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-4.5A)
CNP  A 760 (-3.6A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.58A 6ekuA-4sliA:
39.7		 6ekuA-4sliA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		6 / 12 ILE A 294
ASP A 375
GLU A 595
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-4.5A)
CNP  A 760 (-2.8A)
CNP  A 760 ( 4.5A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.77A 6ekuA-4sliA:
39.7		 6ekuA-4sliA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		5 / 12 ARG A 293
ASP A 318
ARG A 611
ARG A 673
TYR A 713
 CNP  A 760 (-3.0A)
CNP  A 760 (-2.6A)
CNP  A 760 (-3.0A)
CNP  A 760 (-3.0A)
CNP  A 760 (-4.0A)
 0.60A 6hcxA-4sliA:
11.5		 6hcxA-4sliA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4sli INTRAMOLECULAR
TRANS-SIALIDASE
(Macrobdella
decora) 		4 / 6 ASP A 705
TYR A 728
GLU A 748
GLU A 754
 None
 1.33A 6mn5A-4sliA:
undetectable		 6mn5A-4sliA:
10.35