SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 GLY A 157
ALA A 166
GLY A 195
SER A 150
HIS A 172
 None
 1.12A 1kiaA-4tkmA:
7.3		 1kiaA-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
SER A 167
 None
SO4  A 303 (-3.5A)
None
None
None
 1.24A 1nbhA-4tkmA:
7.4		 1nbhA-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
SER A 167
 None
SO4  A 303 (-3.5A)
None
None
None
 1.24A 1nbhC-4tkmA:
6.8		 1nbhC-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
ILE A  19
GLY A 149
ALA A 169
SER A 167
 None
SO4  A 303 (-3.5A)
None
None
None
 1.25A 1nbhD-4tkmA:
6.7		 1nbhD-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
GLY A 149
THR A 148
ALA A 169
SER A 167
 None
 1.15A 1nbiC-4tkmA:
7.0		 1nbiC-4tkmA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 TYR A 164
GLY A 149
THR A 148
ALA A 169
SER A 167
 None
 1.15A 1nbiD-4tkmA:
6.5		 1nbiD-4tkmA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 MET A 124
LEU A  75
ALA A  93
SER A  38
VAL A  40
 None
None
SO4  A 304 ( 4.0A)
SO4  A 304 (-3.3A)
None
 1.22A 2c12C-4tkmA:
undetectable		 2c12C-4tkmA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.03A 2japA-4tkmA:
29.8		 2japA-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.58A 2japA-4tkmA:
29.8		 2japA-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 1.06A 2japB-4tkmA:
29.8		 2japB-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.59A 2japB-4tkmA:
29.8		 2japB-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
THR A 196
 None
 1.04A 2japC-4tkmA:
29.8		 2japC-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.59A 2japC-4tkmA:
29.8		 2japC-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 LEU A  96
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 1.07A 2japD-4tkmA:
29.8		 2japD-4tkmA:
33.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		6 / 12 SER A 150
ILE A 151
ALA A 152
ALA A 161
TYR A 164
THR A 196
 None
 0.62A 2japD-4tkmA:
29.8		 2japD-4tkmA:
33.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 7 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.87A 3u5kB-4tkmA:
undetectable		 3u5kB-4tkmA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 8 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.85A 3u5kC-4tkmA:
undetectable		 3u5kC-4tkmA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 5 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.86A 4a9jA-4tkmA:
undetectable		 4a9jA-4tkmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 5 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.90A 4a9jB-4tkmA:
undetectable		 4a9jB-4tkmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 5 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.85A 4a9jC-4tkmA:
undetectable		 4a9jC-4tkmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		4 / 8 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.88A 5y1yA-4tkmA:
undetectable		 5y1yA-4tkmA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 11 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.19A 6qgbA-4tkmA:
3.2		 6qgbA-4tkmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 10 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.19A 6qgbB-4tkmA:
1.9		 6qgbB-4tkmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 10 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.18A 6qgbD-4tkmA:
0.9		 6qgbD-4tkmA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE
(Sphingomonas
sp.
A1) 		5 / 11 SER A 147
LEU A  89
ALA A 128
TRP A 178
HIS A 175
 None
 1.18A 6qgbE-4tkmA:
3.0		 6qgbE-4tkmA:
18.20