SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LH8_A_VIBA1_1 (MAJOR PRION PROTEIN)	4tko	EMRA (Aquifex aeolicus)	4 / 6	PRO B 277 ASP B 61 ASP B 64 TYR B 65	None	1.47A	2lh8A-4tkoB: 3.2	2lh8A-4tkoB: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_C_LEIC16_0 (COIL SER L16D-PEN)	4tko	EMRA (Aquifex aeolicus)	4 / 6	LYS B 104 GLN B 106 LEU B 108 GLU B 109	None	0.58A	3h5gB-4tkoB: undetectable 3h5gC-4tkoB: undetectable	3h5gB-4tkoB: 6.42 3h5gC-4tkoB: 6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M6T_A_SAMA201_0 (RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG, LINKER, RNA POLYMERASE-ASSOCIATE D PROTEIN LEO1)	4tko	EMRA (Aquifex aeolicus)	4 / 4	ILE B 370 VAL B 296 VAL B 294 ARG B 372	None	1.21A	4m6tA-4tkoB: undetectable	4m6tA-4tkoB: 19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	4tko	EMRA (Aquifex aeolicus)	4 / 5	ARG B 153 LEU B 157 GLN B 159 PHE B 158	None	1.33A	6nmpP-4tkoB: 3.2 6nmpW-4tkoB: 1.3	6nmpP-4tkoB: 20.45 6nmpW-4tkoB: 9.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2LH8_A_VIBA1_1","MAJOR PRION PROTEIN","4tko","EMRA","Aquifex aeolicus",4,"PRO B 277;ASP B  61;ASP B  64;TYR B  65","None","1.47A","2lh8A-4tkoB:3.2","2lh8A-4tkoB:13.25"],["3H5G_C_LEIC16_0","COIL SER L16D-PEN","4tko","EMRA","Aquifex aeolicus",4,"LYS B 104;GLN B 106;LEU B 108;GLU B 109","None","0.58A","3h5gB-4tkoB:undetectable;3h5gC-4tkoB:undetectable","3h5gB-4tkoB:6.42;3h5gC-4tkoB:6.42"],["4M6T_A_SAMA201_0","RNA POLYMERASE II-ASSOCIATED FACTOR 1 HOMOLOG, LINKER, RNA POLYMERASE-ASSOCIATED PROTEIN LEO1","4tko","EMRA","Aquifex aeolicus",4,"ILE B 370;VAL B 296;VAL B 294;ARG B 372","None","1.21A","4m6tA-4tkoB:undetectable","4m6tA-4tkoB:19.22"],["6NMP_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","4tko","EMRA","Aquifex aeolicus",4,"ARG B 153;LEU B 157;GLN B 159;PHE B 158","None","1.33A","6nmpP-4tkoB:3.2;6nmpW-4tkoB:1.3","6nmpP-4tkoB:20.45;6nmpW-4tkoB:9.25"]]