SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		4 / 5 LEU A 104
ALA A 116
ILE A 113
SER A 173
 None
None
BGL  A 305 ( 4.8A)
BGL  A 305 ( 3.9A)
 0.96A 2othA-4tkrA:
undetectable		 2othA-4tkrA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 10 LEU A 109
ALA A 116
GLY A 169
ILE A 171
ILE A 113
 None
None
None
None
BGL  A 305 ( 4.8A)
 1.00A 3ekpC-4tkrA:
undetectable		 3ekpC-4tkrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 11 GLY A 124
ILE A  40
SER A  36
VAL A 165
SER A 168
 None
None
TPP  A 301 (-2.9A)
None
None
 1.12A 3gyqB-4tkrA:
undetectable		 3gyqB-4tkrA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_A_VIBA191_1
(THIT)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		6 / 10 GLU A  82
TYR A  83
HIS A 131
GLY A 135
TRP A 139
ASN A 157
 TPP  A 301 (-2.8A)
TPP  A 301 (-4.6A)
TPP  A 301 (-3.6A)
TPP  A 301 (-3.3A)
TPP  A 301 (-3.4A)
TPP  A 301 (-3.1A)
 0.19A 3rlbA-4tkrA:
27.0		 3rlbA-4tkrA:
37.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RLB_B_VIBB187_1
(THIT)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		7 / 12 GLU A  82
TYR A  83
TYR A 128
HIS A 131
GLY A 135
TRP A 139
ASN A 157
 TPP  A 301 (-2.8A)
TPP  A 301 (-4.6A)
None
TPP  A 301 (-3.6A)
TPP  A 301 (-3.3A)
TPP  A 301 (-3.4A)
TPP  A 301 (-3.1A)
 0.37A 3rlbB-4tkrA:
27.1		 3rlbB-4tkrA:
37.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 12 PHE A 183
LEU A 175
GLY A  38
LEU A  37
SER A 168
 None
 0.97A 3tbgA-4tkrA:
undetectable		 3tbgA-4tkrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		5 / 12 PHE A 183
LEU A 175
GLY A  38
LEU A  37
SER A 168
 None
 0.94A 3tbgB-4tkrA:
undetectable		 3tbgB-4tkrA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		3 / 3 SER A  36
SER A  34
PHE A  87
 TPP  A 301 (-2.9A)
TPP  A 301 (-3.0A)
TPP  A 301 (-4.8A)
 0.50A 5mugA-4tkrA:
undetectable		 5mugA-4tkrA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4tkr THIAMINE TRANSPORTER
THIA
(Listeria
monocytogenes) 		4 / 4 LEU A  63
LEU A  60
SER A  88
ALA A  57
 None
 1.13A 5uunA-4tkrA:
undetectable		 5uunA-4tkrA:
21.10