SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TRP A3713
ALA A3722
VAL A3719
None
0.83A 1c4dC-4tktA:
undetectable
1c4dD-4tktA:
undetectable
1c4dC-4tktA:
1.99
1c4dD-4tktA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 VAL A3303
LEU A3307
LEU A3240
THR A3238
THR A3239
None
1.05A 1dmyA-4tktA:
undetectable
1dmyA-4tktA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 PHE A3268
SER A3304
ALA A3300
PHE A3232
None
1.01A 1fxvA-4tktA:
undetectable
1fxvB-4tktA:
undetectable
1fxvA-4tktA:
15.11
1fxvB-4tktA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 TRP A3546
LEU A3558
GLY A3556
LYS A3507
None
1.33A 1gtiC-4tktA:
undetectable
1gtiC-4tktA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 PRO A3312
GLY A3337
CYH A3339
LEU A3329
PHE A3268
None
1.45A 1h4oA-4tktA:
undetectable
1h4oB-4tktA:
undetectable
1h4oA-4tktA:
14.92
1h4oB-4tktA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 8 PRO A3312
GLY A3337
CYH A3339
LEU A3329
PHE A3268
None
1.46A 1h4oG-4tktA:
undetectable
1h4oG-4tktA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ILE A3493
GLY A3201
SER A3198
TRP A3180
SER A3350
None
1.34A 1nbhA-4tktA:
undetectable
1nbhA-4tktA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ILE A3493
GLY A3201
SER A3198
TRP A3180
SER A3350
None
1.35A 1nbhD-4tktA:
undetectable
1nbhD-4tktA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 GLY A3501
ALA A3506
HIS A3569
ILE A3502
GLY A3557
None
1.20A 1utdU-4tktA:
undetectable
1utdV-4tktA:
undetectable
1utdU-4tktA:
8.64
1utdV-4tktA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.41A 1v54A-4tktA:
undetectable
1v54C-4tktA:
undetectable
1v54A-4tktA:
21.34
1v54C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 1v54N-4tktA:
undetectable
1v54P-4tktA:
undetectable
1v54N-4tktA:
21.34
1v54P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.43A 1v55A-4tktA:
undetectable
1v55C-4tktA:
undetectable
1v55A-4tktA:
21.34
1v55C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TRP A3200
THR A3196
TYR A3197
None
1.03A 2a3aA-4tktA:
undetectable
2a3aA-4tktA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TRP A3200
THR A3196
TYR A3197
None
0.99A 2a3aB-4tktA:
undetectable
2a3aB-4tktA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TRP A3200
THR A3196
TYR A3197
None
1.05A 2a3bA-4tktA:
undetectable
2a3bA-4tktA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 2dyrA-4tktA:
undetectable
2dyrC-4tktA:
undetectable
2dyrA-4tktA:
21.34
2dyrC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 2dyrN-4tktA:
undetectable
2dyrP-4tktA:
undetectable
2dyrN-4tktA:
21.34
2dyrP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2dysA-4tktA:
undetectable
2dysC-4tktA:
undetectable
2dysA-4tktA:
21.34
2dysC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2dysN-4tktA:
undetectable
2dysP-4tktA:
undetectable
2dysN-4tktA:
21.34
2dysP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2eijA-4tktA:
undetectable
2eijC-4tktA:
undetectable
2eijA-4tktA:
21.34
2eijC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 2eijN-4tktA:
undetectable
2eijP-4tktA:
undetectable
2eijN-4tktA:
21.34
2eijP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 2eikA-4tktA:
undetectable
2eikC-4tktA:
undetectable
2eikA-4tktA:
21.34
2eikC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.43A 2eikN-4tktA:
undetectable
2eikP-4tktA:
undetectable
2eikN-4tktA:
21.34
2eikP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 2eilA-4tktA:
undetectable
2eilC-4tktA:
undetectable
2eilA-4tktA:
21.34
2eilC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.43A 2eilN-4tktA:
undetectable
2eilP-4tktA:
undetectable
2eilN-4tktA:
21.34
2eilP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.47A 2eimA-4tktA:
undetectable
2eimC-4tktA:
undetectable
2eimA-4tktA:
21.34
2eimC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.48A 2eimN-4tktA:
undetectable
2eimP-4tktA:
undetectable
2eimN-4tktA:
21.34
2eimP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2einA-4tktA:
undetectable
2einC-4tktA:
undetectable
2einA-4tktA:
21.34
2einC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2einN-4tktA:
undetectable
2einP-4tktA:
undetectable
2einN-4tktA:
21.34
2einP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 THR A3315
ILE A3265
GLY A3266
LEU A3334
GLY A3340
None
0.97A 2fk8A-4tktA:
undetectable
2fk8A-4tktA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A3231
ARG A3230
PHE A3741
GLY A3388
LEU A3158
None
1.23A 2lbdA-4tktA:
undetectable
2lbdA-4tktA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 ALA A3563
VAL A3425
PHE A3364
THR A3459
None
1.31A 2pkkA-4tktA:
undetectable
2pkkA-4tktA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.46A 2y69A-4tktA:
undetectable
2y69C-4tktA:
undetectable
2y69A-4tktA:
21.34
2y69C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3345
GLY A3388
ALA A3506
LEU A3505
PHE A3268
None
0.94A 2yvlA-4tktA:
undetectable
2yvlA-4tktA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3345
GLY A3388
ALA A3506
LEU A3505
PHE A3268
None
0.93A 2yvlB-4tktA:
undetectable
2yvlB-4tktA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3345
GLY A3388
ALA A3506
LEU A3505
PHE A3268
None
0.94A 2yvlD-4tktA:
undetectable
2yvlD-4tktA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 9 ALA A3271
VAL A3316
VAL A3347
GLY A3346
GLY A3345
LEU A3296
None
1.05A 2z0yA-4tktA:
undetectable
2z0yA-4tktA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 9 ALA A3271
VAL A3316
VAL A3347
GLY A3345
LEU A3296
None
0.82A 2z0yB-4tktA:
undetectable
2z0yB-4tktA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 2zxwA-4tktA:
undetectable
2zxwC-4tktA:
undetectable
2zxwA-4tktA:
21.34
2zxwC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.48A 2zxwN-4tktA:
undetectable
2zxwP-4tktA:
undetectable
2zxwN-4tktA:
21.34
2zxwP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 3abkA-4tktA:
undetectable
3abkC-4tktA:
undetectable
3abkA-4tktA:
21.34
3abkC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.46A 3abkN-4tktA:
undetectable
3abkP-4tktA:
undetectable
3abkN-4tktA:
21.34
3abkP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.48A 3abmN-4tktA:
undetectable
3abmP-4tktA:
undetectable
3abmN-4tktA:
21.34
3abmP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.37A 3ag1A-4tktA:
undetectable
3ag1C-4tktA:
undetectable
3ag1A-4tktA:
21.34
3ag1C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.40A 3ag1N-4tktA:
undetectable
3ag1P-4tktA:
undetectable
3ag1N-4tktA:
21.34
3ag1P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 3ag2A-4tktA:
undetectable
3ag2C-4tktA:
undetectable
3ag2A-4tktA:
21.34
3ag2C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 3ag2N-4tktA:
undetectable
3ag2P-4tktA:
undetectable
3ag2N-4tktA:
21.34
3ag2P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 3ag3A-4tktA:
undetectable
3ag3C-4tktA:
undetectable
3ag3A-4tktA:
21.34
3ag3C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 3ag3N-4tktA:
2.1
3ag3P-4tktA:
undetectable
3ag3N-4tktA:
21.34
3ag3P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 3ag4A-4tktA:
undetectable
3ag4C-4tktA:
undetectable
3ag4A-4tktA:
21.34
3ag4C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.47A 3ag4N-4tktA:
undetectable
3ag4P-4tktA:
undetectable
3ag4N-4tktA:
21.34
3ag4P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 3asnA-4tktA:
undetectable
3asnC-4tktA:
undetectable
3asnA-4tktA:
21.34
3asnC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 4 LEU A3634
ARG A3621
LEU A3617
ALA A3735
None
GOL  A4006 (-3.0A)
None
GOL  A4006 (-3.6A)
1.18A 3b9mA-4tktA:
undetectable
3b9mA-4tktA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ILE A3265
GLY A3266
GLY A3311
ALA A3333
ALA A3300
None
0.96A 3jb2A-4tktA:
undetectable
3jb2A-4tktA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A3204
PHE A3232
CYH A3235
THR A3238
LEU A3158
None
1.15A 3sp9B-4tktA:
undetectable
3sp9B-4tktA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 PHE A3537
ASN A3482
ALA A3480
THR A3478
None
1.18A 3t3sB-4tktA:
undetectable
3t3sB-4tktA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3230
THR A3749
TRP A3747
None
None
MES  A4004 (-3.5A)
0.96A 4d7hA-4tktA:
undetectable
4d7hA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3745
THR A3749
TRP A3747
MES  A4004 ( 4.7A)
None
MES  A4004 (-3.5A)
0.75A 4d7hA-4tktA:
undetectable
4d7hA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 GLY A3345
ALA A3344
ILE A3327
LEU A3509
ILE A3145
None
1.03A 4dt8B-4tktA:
undetectable
4dt8B-4tktA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 CYH A3320
HIS A3455
THR A3457
HIS A3495
GLY A3562
None
0.52A 4ls7A-4tktA:
48.6
4ls7A-4tktA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 CYH A3320
HIS A3455
THR A3457
HIS A3495
GLY A3562
None
0.51A 4ls7A-4tktA:
48.6
4ls7B-4tktA:
48.3
4ls7A-4tktA:
22.64
4ls7B-4tktA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3346
GLY A3270
LEU A3296
SER A3325
ALA A3499
None
1.09A 4qtuB-4tktA:
undetectable
4qtuB-4tktA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 TYR A3273
SER A3350
ALA A3500
ALA A3499
TYR A3381
None
1.38A 4u15B-4tktA:
undetectable
4u15B-4tktA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3230
THR A3749
TRP A3747
None
None
MES  A4004 (-3.5A)
0.97A 4ug5A-4tktA:
undetectable
4ug5A-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3745
THR A3749
TRP A3747
MES  A4004 ( 4.7A)
None
MES  A4004 (-3.5A)
0.78A 4ug5A-4tktA:
undetectable
4ug5A-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3230
THR A3749
TRP A3747
None
None
MES  A4004 (-3.5A)
1.02A 4uglA-4tktA:
0.9
4uglA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3745
THR A3749
TRP A3747
MES  A4004 ( 4.7A)
None
MES  A4004 (-3.5A)
0.72A 4uglA-4tktA:
0.9
4uglA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3716
LEU A3717
ALA A3646
VAL A3719
PHE A3693
None
1.05A 4wnwB-4tktA:
undetectable
4wnwB-4tktA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ALA A3236
LEU A3233
LEU A3307
LEU A3250
GLY A3311
None
1.06A 4xi3C-4tktA:
undetectable
4xi3C-4tktA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 LEU A3510
VAL A3390
ILE A3502
ILE A3145
GLY A3407
None
0.88A 4y8wC-4tktA:
undetectable
4y8wC-4tktA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 THR A3315
HIS A3237
LEU A3307
None
0.78A 5axdA-4tktA:
undetectable
5axdA-4tktA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 5b1aN-4tktA:
undetectable
5b1aP-4tktA:
undetectable
5b1aN-4tktA:
21.34
5b1aP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 5b1bN-4tktA:
undetectable
5b1bP-4tktA:
undetectable
5b1bN-4tktA:
21.34
5b1bP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.45A 5b3sN-4tktA:
undetectable
5b3sP-4tktA:
undetectable
5b3sN-4tktA:
21.34
5b3sP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ALA A3500
SER A3498
SER A3350
PRO A3153
None
1.18A 5c6pA-4tktA:
undetectable
5c6pA-4tktA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ILE A3493
GLY A3384
PHE A3161
LEU A3204
LEU A3349
None
1.18A 5fhzC-4tktA:
undetectable
5fhzC-4tktA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3230
THR A3749
TRP A3747
None
None
MES  A4004 (-3.5A)
0.98A 5g6cA-4tktA:
undetectable
5g6cA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 ARG A3745
THR A3749
TRP A3747
MES  A4004 ( 4.7A)
None
MES  A4004 (-3.5A)
0.71A 5g6cA-4tktA:
undetectable
5g6cA-4tktA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 ALA A3321
GLY A3564
GLY A3501
SER A3560
HIS A3455
None
1.08A 5gwxA-4tktA:
undetectable
5gwxA-4tktA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 11 GLY A3557
ALA A3442
VAL A3571
SER A3559
ILE A3449
None
1.22A 5i3cC-4tktA:
undetectable
5i3cC-4tktA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.46A 5iy5A-4tktA:
undetectable
5iy5C-4tktA:
undetectable
5iy5A-4tktA:
21.34
5iy5C-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 10 ILE A3217
PHE A3215
PRO A3219
ALA A3222
PHE A3210
None
1.22A 5m0oA-4tktA:
undetectable
5m0oA-4tktA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 9 GLY A3266
ALA A3342
CYH A3339
GLY A3311
GLU A3338
None
1.31A 5vw4A-4tktA:
undetectable
5vw4A-4tktA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 SER A3559
GLY A3504
ALA A3503
SER A3322
GLU A3466
None
1.49A 5wbvA-4tktA:
undetectable
5wbvA-4tktA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.44A 5x19N-4tktA:
0.4
5x19P-4tktA:
undetectable
5x19N-4tktA:
21.34
5x19P-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 5x1bN-4tktA:
undetectable
5x1bP-4tktA:
undetectable
5x1bN-4tktA:
21.34
5x1bP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.42A 5x1fN-4tktA:
undetectable
5x1fP-4tktA:
undetectable
5x1fN-4tktA:
21.34
5x1fP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.46A 5zcqN-4tktA:
undetectable
5zcqP-4tktA:
undetectable
5zcqN-4tktA:
21.34
5zcqP-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 GLY A3637
SER A3609
ASP A3615
ALA A3616
ARG A3618
None
1.34A 5zvgA-4tktA:
undetectable
5zvgA-4tktA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
5 / 12 PHE A3214
ALA A3344
ALA A3342
LEU A3250
LEU A3307
None
1.11A 6aybA-4tktA:
undetectable
6aybA-4tktA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 PHE A3214
ARG A3247
ALA A3640
None
CL  A4001 (-4.4A)
None
0.98A 6ecfB-4tktA:
undetectable
6ecfB-4tktA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
3 / 3 TYR A3739
HIS A3237
PHE A3214
None
1.03A 6esmA-4tktA:
undetectable
6esmA-4tktA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
6 / 10 VAL A3596
ALA A3631
LEU A3655
LEU A3652
LEU A3736
LEU A3613
None
None
None
SO4  A4003 ( 4.8A)
None
None
1.25A 6f5uA-4tktA:
undetectable
6f5uB-4tktA:
undetectable
6f5uA-4tktA:
9.18
6f5uB-4tktA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 LEU A3736
THR A3633
GLY A3244
ARG A3638
None
1.39A 6gtqB-4tktA:
undetectable
6gtqD-4tktA:
undetectable
6gtqB-4tktA:
14.56
6gtqD-4tktA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 6 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.43A 6nknA-4tktA:
undetectable
6nknC-4tktA:
undetectable
6nknA-4tktA:
21.34
6nknC-4tktA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis)
4 / 7 ASP A3187
THR A3196
TYR A3197
HIS A3352
None
1.49A 6nmfN-4tktA:
undetectable
6nmfP-4tktA:
undetectable
6nmfN-4tktA:
21.34
6nmfP-4tktA:
17.31