SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 7 TYR L 414
TYR L 541
GLY L 539
TRP L 519
 None
 1.26A 1mxgA-4tkxL:
undetectable		 1mxgA-4tkxL:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 4 LYS L 294
LEU L 245
LEU L 308
SER L 334
 None
 1.34A 1tt6A-4tkxL:
undetectable		 1tt6A-4tkxL:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 11 ALA L 564
ALA L 563
LEU L 562
ALA L 578
ILE L 473
 None
 1.05A 2aclE-4tkxL:
undetectable		 2aclE-4tkxL:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 PHE L 489
TYR L 484
ALA L 480
GLY L 506
TRP L 450
 None
 1.23A 2igtC-4tkxL:
3.1		 2igtC-4tkxL:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ASN L 551
TYR L 502
TYR L 414
SER L 437
ASP L 542
 NA  L 705 (-3.3A)
None
None
None
NA  L 706 (-2.8A)
 1.15A 2iyfB-4tkxL:
3.2		 2iyfB-4tkxL:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_2
(PROTEASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 9 LEU L 460
ALA L 472
GLY L 506
VAL L 492
ILE L 493
 None
None
None
EDO  L 710 ( 4.4A)
None
 0.93A 2o4pB-4tkxL:
undetectable		 2o4pB-4tkxL:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 LEU L 460
ALA L 472
GLY L 506
VAL L 492
ILE L 493
 None
None
None
EDO  L 710 ( 4.4A)
None
 0.96A 2q63B-4tkxL:
undetectable		 2q63B-4tkxL:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 4 GLY L 474
ASP L 516
GLY L 560
THR L 544
 None
TCK  L 720 (-3.0A)
None
None
 1.02A 3k4vC-4tkxL:
undetectable		 3k4vC-4tkxL:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 VAL L 311
SER L 592
ILE L 361
VAL L 364
LEU L 365
 None
 1.03A 3w68A-4tkxL:
undetectable		 3w68A-4tkxL:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 7 THR L 544
ASN L 440
LEU L 383
PHE L 545
 None
 1.24A 4awuA-4tkxL:
undetectable		 4awuA-4tkxL:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 VAL L 641
ALA L 629
PHE L 268
MET L 594
THR L 639
 None
 1.30A 4eilG-4tkxL:
undetectable		 4eilG-4tkxL:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 7 VAL L 364
PHE L 307
GLY L 591
THR L 552
PHE L 268
 None
 1.47A 4ejjB-4tkxL:
undetectable		 4ejjB-4tkxL:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 VAL L 641
ALA L 629
PHE L 268
MET L 594
THR L 639
 None
 1.36A 4kyaB-4tkxL:
2.5		 4kyaB-4tkxL:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA L 472
ALA L 449
ASN L 433
LEU L 463
GLY L 500
 None
None
EDO  L 709 (-3.7A)
EDO  L 709 ( 4.5A)
None
 1.14A 4r38A-4tkxL:
undetectable		 4r38A-4tkxL:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA L 472
ALA L 449
ASN L 433
LEU L 463
GLY L 500
 None
None
EDO  L 709 (-3.7A)
EDO  L 709 ( 4.5A)
None
 1.13A 4r38B-4tkxL:
undetectable		 4r38B-4tkxL:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA L 472
ALA L 449
ASN L 433
LEU L 463
GLY L 500
 None
None
EDO  L 709 (-3.7A)
EDO  L 709 ( 4.5A)
None
 1.14A 4r38C-4tkxL:
undetectable		 4r38C-4tkxL:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA L 472
ALA L 449
ASN L 433
LEU L 463
GLY L 500
 None
None
EDO  L 709 (-3.7A)
EDO  L 709 ( 4.5A)
None
 1.14A 4r38D-4tkxL:
undetectable		 4r38D-4tkxL:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 10 ILE L 556
GLY L 506
SER L 520
GLY L 560
VAL L 587
 None
 1.12A 5i6xA-4tkxL:
undetectable		 5i6xA-4tkxL:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 ALA L 248
GLY L 249
VAL L 280
LEU L 270
ARG L 348
 None
 1.00A 5w7pA-4tkxL:
undetectable		 5w7pA-4tkxL:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 11 ALA L 584
SER L 511
VAL L 521
ASN L 475
THR L 442
 None
TCK  L 720 (-2.6A)
NA  L 706 (-4.9A)
None
TCK  L 720 (-3.5A)
 0.96A 5y80A-4tkxL:
undetectable		 5y80A-4tkxL:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 PHE L 347
VAL L 587
VAL L 242
SER L 592
VAL L 553
 None
 1.28A 6ap6A-4tkxL:
undetectable		 6ap6A-4tkxL:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		5 / 12 PHE L 347
VAL L 587
VAL L 242
SER L 592
VAL L 553
 None
 1.28A 6ap6B-4tkxL:
undetectable		 6ap6B-4tkxL:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 8 ASP L 236
GLY L 640
SER L 651
ASN L 239
 None
None
None
EDO  L 717 ( 3.0A)
 1.06A 6giqL-4tkxL:
undetectable
6giqP-4tkxL:
undetectable
6giqT-4tkxL:
undetectable		 6giqL-4tkxL:
23.78
6giqP-4tkxL:
18.89
6giqT-4tkxL:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4tkx LYS-GINGIPAIN W83
(Porphyromonas
gingivalis) 		4 / 8 ASP L 388
HIS L 444
ASP L 516
GLU L 515
 K  L 707 (-3.0A)
TCK  L 720 ( 3.6A)
TCK  L 720 (-3.0A)
None
 1.17A 6mn4A-4tkxL:
undetectable		 6mn4A-4tkxL:
20.05