SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tl9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 GLY A  51
PHE A 247
ILE A 239
GLN A  58
 AGS  A 303 (-3.2A)
None
AGS  A 303 ( 3.9A)
None
 0.96A 2a8tB-4tl9A:
undetectable		 2a8tB-4tl9A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 6 VAL A 205
ILE A  31
HIS A 230
LEU A 223
 None
 0.76A 3hegA-4tl9A:
undetectable		 3hegA-4tl9A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		4 / 8 THR A  42
LEU A  36
SER A  32
HIS A 230
 None
 1.02A 3kp2A-4tl9A:
undetectable
3kp2B-4tl9A:
undetectable		 3kp2A-4tl9A:
21.83
3kp2B-4tl9A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_1
(ADENOSINE KINASE)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ASN A 245
LEU A  54
GLY A  27
GLY A  35
ASP A  29
 None
AGS  A 303 (-4.2A)
None
None
None
 1.12A 4n09A-4tl9A:
3.0		 4n09A-4tl9A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		3 / 3 ILE A  65
MET A  21
ASP A  68
 None
 0.77A 5h2uA-4tl9A:
undetectable		 5h2uA-4tl9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 4tl9 CIRCADIAN CLOCK
PROTEIN KINASE KAIC
(Synechococcus
elongatus) 		5 / 12 ALA A  87
GLY A 243
ILE A 239
SER A  56
ILE A  57
 None
None
AGS  A 303 ( 3.9A)
None
None
 0.85A 5t2zA-4tl9A:
undetectable		 5t2zA-4tl9A:
19.11