SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tlg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		3 / 3 SER A 210
GLU A 211
GLU A 212
 EDO  A 501 ( 4.6A)
None
None
 0.50A 1eqbD-4tlgA:
undetectable		 1eqbD-4tlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		3 / 3 SER A 210
GLU A 211
GLU A 212
 EDO  A 501 ( 4.6A)
None
None
 0.51A 1eqbB-4tlgA:
undetectable		 1eqbB-4tlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		5 / 12 PRO A 199
ILE A 192
ILE A 219
GLU A 240
PHE A 241
 EDO  A 512 ( 4.7A)
None
None
None
None
 1.15A 1sg9A-4tlgA:
3.2		 1sg9A-4tlgA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		5 / 10 ALA A 194
ALA A 201
LEU A 204
LEU A 163
LEU A 394
 None
11A  A 518 ( 4.1A)
None
EDO  A 503 (-4.4A)
None
 1.13A 2bxqA-4tlgA:
undetectable		 2bxqA-4tlgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 7 ILE A 192
PRO A 252
GLY A 243
MET A 245
 None
None
None
EDO  A 517 (-4.5A)
 1.04A 2pnjB-4tlgA:
undetectable		 2pnjB-4tlgA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 6 ILE A 232
PHE A 100
GLY A 242
GLY A 243
 None
 0.79A 2qx6A-4tlgA:
undetectable
2qx6B-4tlgA:
undetectable		 2qx6A-4tlgA:
19.40
2qx6B-4tlgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 6 THR A 354
VAL A 302
LEU A 197
SER A 352
 None
None
None
EDO  A 503 (-2.7A)
 1.07A 3b6rB-4tlgA:
undetectable		 3b6rB-4tlgA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 7 VAL A 239
ILE A 258
GLY A  87
LEU A 131
 None
None
None
EDO  A 513 ( 4.1A)
 0.87A 3bjwB-4tlgA:
undetectable		 3bjwB-4tlgA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 7 VAL A 239
ILE A 258
GLY A  87
LEU A 131
 None
None
None
EDO  A 513 ( 4.1A)
 0.87A 3bjwF-4tlgA:
undetectable		 3bjwF-4tlgA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		5 / 12 HIS A 162
GLY A 261
GLY A 104
LEU A  82
ASP A 107
 EDO  A 509 ( 3.6A)
None
None
None
EDO  A 509 (-3.7A)
 1.14A 4blvB-4tlgA:
undetectable		 4blvB-4tlgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 8 SER A 288
SER A 289
ASN A 367
GLY A 315
 None
None
None
EDO  A 510 ( 3.7A)
 0.89A 4fo4B-4tlgA:
undetectable		 4fo4B-4tlgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		5 / 12 GLY A 242
GLY A 243
THR A 244
ILE A 232
PHE A 100
 None
 0.86A 4zvmA-4tlgA:
undetectable
4zvmB-4tlgA:
undetectable		 4zvmA-4tlgA:
19.40
4zvmB-4tlgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 5 VAL A  79
LEU A 270
CYH A 271
ASP A 107
 None
None
None
EDO  A 509 (-3.7A)
 1.44A 5vcvA-4tlgA:
undetectable		 5vcvA-4tlgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4tlg SEC14-LIKE PROTEIN 4
(Homo
sapiens) 		4 / 5 LEU A 363
GLN A 291
PHE A 319
PHE A 307
 None
 1.37A 6nmpP-4tlgA:
undetectable
6nmpW-4tlgA:
undetectable		 6nmpP-4tlgA:
20.84
6nmpW-4tlgA:
10.89