SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tlh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 5 ASP A  52
GLU A 143
THR A 138
LEU A 135
 None
 1.15A 1u18B-4tlhA:
undetectable		 1u18B-4tlhA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		3 / 3 LEU A 147
TYR A 149
GLN A 126
 None
 0.58A 2wekA-4tlhA:
undetectable		 2wekA-4tlhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 8 GLY A  71
ILE A   6
PHE A 203
PHE A 184
 None
 0.81A 3ko0B-4tlhA:
undetectable
3ko0J-4tlhA:
undetectable		 3ko0B-4tlhA:
17.54
3ko0J-4tlhA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		5 / 12 TYR A 134
PHE A 112
ILE A 106
THR A  47
ILE A  39
 None
 1.37A 3ndiA-4tlhA:
undetectable		 3ndiA-4tlhA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		3 / 3 TYR A 124
ASP A  44
ASP A  42
 None
 0.94A 3ou7B-4tlhA:
undetectable		 3ou7B-4tlhA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.91A 4f3tA-4tlhA:
undetectable		 4f3tA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 5 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.95A 4w5oA-4tlhA:
undetectable		 4w5oA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.92A 4w5qA-4tlhA:
undetectable		 4w5qA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.96A 4w5rA-4tlhA:
undetectable		 4w5rA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.92A 4w5tA-4tlhA:
undetectable		 4w5tA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 5 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.95A 4z4cA-4tlhA:
undetectable		 4z4cA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 5 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.96A 4z4dA-4tlhA:
undetectable		 4z4dA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 5 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.97A 4z4eA-4tlhA:
undetectable		 4z4eA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.92A 4z4gA-4tlhA:
undetectable		 4z4gA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		3 / 3 VAL A 151
ALA A 187
PHE A 203
 None
 0.75A 4z4iA-4tlhA:
undetectable		 4z4iA-4tlhA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 7 VAL A 128
LEU A 135
SER A 136
GLU A 143
 None
 0.89A 4zphA-4tlhA:
undetectable
4zphB-4tlhA:
undetectable		 4zphA-4tlhA:
20.41
4zphB-4tlhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 8 GLY A  71
GLU A  82
TYR A  48
ASP A  45
 None
 0.94A 5gqbA-4tlhA:
undetectable		 5gqbA-4tlhA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		3 / 3 VAL A 151
ALA A 187
PHE A 203
 None
 0.75A 5js1A-4tlhA:
undetectable		 5js1A-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		5 / 12 ALA A 101
VAL A  60
GLY A  89
ALA A  88
SER A  35
 None
 1.05A 5jw1A-4tlhA:
undetectable		 5jw1A-4tlhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.92A 5ki6A-4tlhA:
undetectable		 5ki6A-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		4 / 6 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.88A 5t7bA-4tlhA:
undetectable		 5t7bA-4tlhA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL
(Clostridium
perfringens) 		5 / 12 GLY A  98
ILE A  84
VAL A  13
LEU A  38
GLY A  37
 None
 1.05A 5wyqA-4tlhA:
undetectable		 5wyqA-4tlhA:
22.39