SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		5 / 12 ALA B 298
LEU B 334
PHE B 141
ALA B 293
THR B 301
 None
 1.07A 1bzfA-4tllB:
undetectable		 1bzfA-4tllB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 8 SER B  71
GLY B 124
THR B  98
GLY B  38
 None
 0.74A 1jr1B-4tllB:
undetectable		 1jr1B-4tllB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 5 ALA B 239
TYR B 234
ILE B 235
ASP B 206
 None
 1.26A 1upfA-4tllB:
undetectable		 1upfA-4tllB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 5 ALA B 239
TYR B 234
ILE B 235
ASP B 206
 None
 1.18A 1upfC-4tllB:
5.1		 1upfC-4tllB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 8 PRO B 117
LEU B 119
GLY B 291
LEU B 334
 None
 0.94A 1ya4A-4tllB:
undetectable		 1ya4A-4tllB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 7 PRO B 117
LEU B 119
GLY B 291
LEU B 334
 None
 0.90A 1ya4B-4tllB:
undetectable		 1ya4B-4tllB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		3 / 3 TYR B 226
TYR B 351
GLY B 173
 None
 0.73A 3eteB-4tllB:
4.4
3eteD-4tllB:
4.4
3eteF-4tllB:
4.4		 3eteB-4tllB:
21.15
3eteD-4tllB:
21.15
3eteF-4tllB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		7 / 11 ALA B 102
GLN B 105
ILE B 106
PHE B 109
THR B 169
PRO B 172
GLU B 231
 QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-3.8A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.51A 3qelA-4tllB:
30.6
3qelB-4tllB:
49.4		 3qelA-4tllB:
18.38
3qelB-4tllB:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		9 / 9 PRO B  73
ALA B 102
GLN B 105
ILE B 106
PHE B 109
THR B 169
PHE B 171
PRO B 172
GLU B 231
 None
QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-3.8A)
QEM  B 901 (-4.7A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.56A 3qelD-4tllB:
28.5		 3qelD-4tllB:
38.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 6 MET B 381
LEU B 379
GLN B 148
TYR B 374
 None
 1.42A 3vkxA-4tllB:
undetectable		 3vkxA-4tllB:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 8 ASP B  99
SER B 255
SER B 274
ASP B 262
 None
 1.20A 4kttC-4tllB:
undetectable		 4kttC-4tllB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 8 ASP B  99
SER B 255
SER B 274
ASP B 262
 None
 1.23A 4ndnA-4tllB:
undetectable		 4ndnA-4tllB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		6 / 10 ALA B 102
GLN B 105
ILE B 106
PHE B 109
PRO B 172
GLU B 231
 QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.48A 4pe5A-4tllB:
30.1
4pe5B-4tllB:
35.9		 4pe5A-4tllB:
29.93
4pe5B-4tllB:
86.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		6 / 10 ALA B 102
GLN B 105
ILE B 106
PHE B 109
PRO B 172
GLU B 231
 QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.53A 4pe5C-4tllB:
30.6
4pe5D-4tllB:
50.2		 4pe5C-4tllB:
29.93
4pe5D-4tllB:
86.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		7 / 11 PRO B  73
ALA B 102
GLN B 105
ILE B 106
PHE B 109
PRO B 172
GLU B 231
 None
QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.55A 5ewjA-4tllB:
30.5
5ewjB-4tllB:
49.3		 5ewjA-4tllB:
19.51
5ewjB-4tllB:
38.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		8 / 12 PRO B  73
ALA B 102
GLN B 105
ILE B 106
PHE B 109
THR B 169
PRO B 172
GLU B 231
 None
QEM  B 901 ( 4.0A)
QEM  B 901 (-3.3A)
QEM  B 901 (-4.6A)
QEM  B 901 (-4.4A)
QEM  B 901 (-3.8A)
QEM  B 901 (-4.5A)
QEM  B 901 (-3.1A)
 0.58A 5ewjC-4tllB:
20.9
5ewjD-4tllB:
48.9		 5ewjC-4tllB:
19.51
5ewjD-4tllB:
38.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4tll RECEPTOR SUBUNIT
GLUN2B
(Xenopus
laevis) 		4 / 8 ASP B  99
SER B 255
SER B 274
ASP B 262
 None
 1.23A 6fcbA-4tllB:
undetectable		 6fcbA-4tllB:
18.99