SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		3 / 3 ASP A  12
ARG A  10
ILE A  48
 None
 0.80A 1a4gB-4tlvA:
undetectable		 1a4gB-4tlvA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 6 PHE A 528
LEU A 477
VAL A 357
VAL A 444
 ACT  A 608 (-4.6A)
None
None
None
 1.11A 1e7aB-4tlvA:
undetectable		 1e7aB-4tlvA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 6 PRO A 210
PHE A 228
ILE A  37
SER A 227
 None
 1.15A 1sbrA-4tlvA:
undetectable
1sbrB-4tlvA:
undetectable		 1sbrA-4tlvA:
15.36
1sbrB-4tlvA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		3 / 3 ASP A 589
ARG A 530
ASP A 586
 None
None
GOL  A 605 ( 4.8A)
 0.67A 1vptA-4tlvA:
undetectable		 1vptA-4tlvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 ARG A  10
SER A  49
GLN A 130
GLU A 132
 None
 1.04A 2c8aA-4tlvA:
undetectable		 2c8aA-4tlvA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 SER A  49
SER A  51
GLN A 130
GLU A 132
 None
 0.86A 2c8aA-4tlvA:
undetectable		 2c8aA-4tlvA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 11 LEU A 277
LEU A 403
SER A 336
LEU A 337
LEU A 288
 None
 0.93A 2ceoA-4tlvA:
undetectable		 2ceoA-4tlvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 PHE A 127
PRO A 210
ALA A 213
ALA A 122
 None
 1.00A 2vcvA-4tlvA:
undetectable		 2vcvA-4tlvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 PHE A 127
PRO A 210
ALA A 213
ALA A 122
 None
 0.89A 2vcvL-4tlvA:
undetectable		 2vcvL-4tlvA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 12 LEU A  78
VAL A 150
THR A  50
SER A  45
PHE A  42
 None
 1.48A 2y01B-4tlvA:
undetectable		 2y01B-4tlvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 12 LEU A  38
GLY A  94
GLY A 119
LEU A 123
LEU A 257
 None
 1.15A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 12 LEU A  38
PRO A 194
GLY A  94
GLY A 119
LEU A 123
 None
 0.92A 3e23A-4tlvA:
undetectable		 3e23A-4tlvA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 8 GLU A  95
PHE A  34
ARG A  91
ARG A 124
 ACT  A 608 (-3.3A)
None
ACT  A 608 (-2.7A)
ACT  A 608 ( 4.9A)
 1.13A 3mjrD-4tlvA:
undetectable		 3mjrD-4tlvA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 ASP A  99
GLY A  94
SER A 529
PHE A 528
 None
None
None
ACT  A 608 (-4.6A)
 1.00A 4ac9C-4tlvA:
undetectable		 4ac9C-4tlvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 7 LEU A  27
SER A 227
GLU A  35
HIS A  36
 None
 1.12A 4aq7A-4tlvA:
2.2		 4aq7A-4tlvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		3 / 3 ASP A 589
ARG A 530
ASP A 586
 None
None
GOL  A 605 ( 4.8A)
 0.83A 4fzvA-4tlvA:
undetectable		 4fzvA-4tlvA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 8 GLU A 416
GLU A 301
ILE A 420
LEU A 288
 None
 0.86A 4mj8A-4tlvA:
undetectable		 4mj8A-4tlvA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 8 ILE A 280
GLU A 417
GLN A 419
ILE A 420
LEU A 390
 None
 0.78A 4mj8A-4tlvA:
undetectable		 4mj8A-4tlvA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 5 LEU A  38
SER A 225
LEU A 123
LEU A 260
 None
 1.28A 4n09B-4tlvA:
undetectable		 4n09B-4tlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 5 LEU A  38
SER A 225
LEU A 123
LEU A 260
 None
 1.27A 4n09D-4tlvA:
undetectable		 4n09D-4tlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 11 ASN A  96
ASP A  99
GLU A  95
ASP A 589
ARG A 124
 None
None
ACT  A 608 (-3.3A)
None
ACT  A 608 ( 4.9A)
 1.42A 4urnC-4tlvA:
undetectable		 4urnC-4tlvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 9 PHE A  60
SER A  63
THR A 171
VAL A 150
VAL A  11
 None
None
GOL  A 606 (-2.9A)
None
None
 1.33A 4wnvB-4tlvA:
undetectable		 4wnvB-4tlvA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 5 PHE A 474
ASP A 476
PHE A 483
VAL A 354
 None
 1.04A 5a1rA-4tlvA:
undetectable		 5a1rA-4tlvA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 12 LEU A 403
ILE A 280
GLY A 279
THR A 285
PHE A 315
 None
 1.26A 5fsaB-4tlvA:
undetectable		 5fsaB-4tlvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		5 / 12 ALA A 216
ILE A  37
LEU A 226
ALA A 229
LEU A 260
 None
 1.20A 6a5zD-4tlvA:
undetectable		 6a5zD-4tlvA:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4tlv ADP-RIBOSYLATING
TOXIN CARDS
(Mycoplasma
pneumoniae) 		4 / 8 ILE A 546
TRP A 526
ARG A 547
ASN A 496
 None
 1.26A 6hisC-4tlvA:
undetectable
6hisD-4tlvA:
undetectable		 6hisC-4tlvA:
9.68
6hisD-4tlvA:
9.68