SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 4tm3 KTZI
(Kutzneria
sp.
744) 		3 / 3 PHE A 186
VAL A 341
TRP A 181
 None
 0.89A 2cc8A-4tm3A:
undetectable		 2cc8A-4tm3A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 4tm3 KTZI
(Kutzneria
sp.
744) 		3 / 3 PHE A 186
VAL A 341
TRP A 181
 None
 0.90A 2ccbA-4tm3A:
undetectable		 2ccbA-4tm3A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 ILE A 415
PHE A  41
GLY A  18
LEU A 405
VAL A  28
 None
None
FAD  A 501 (-3.2A)
BR  A 505 ( 4.0A)
None
 1.36A 2nyrB-4tm3A:
2.1		 2nyrB-4tm3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 PHE A  19
SER A  39
VAL A 146
LEU A 118
LEU A  30
 None
 1.44A 2prgB-4tm3A:
undetectable		 2prgB-4tm3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4tm3 KTZI
(Kutzneria
sp.
744) 		4 / 8 ILE A 284
GLY A 207
GLY A 206
MET A 230
 None
 0.90A 2qx4A-4tm3A:
3.4
2qx4B-4tm3A:
3.5		 2qx4A-4tm3A:
18.58
2qx4B-4tm3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 4tm3 KTZI
(Kutzneria
sp.
744) 		3 / 3 PHE A 186
VAL A 341
TRP A 181
 None
 0.88A 2vx9A-4tm3A:
undetectable		 2vx9A-4tm3A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4tm3 KTZI
(Kutzneria
sp.
744) 		3 / 3 THR A 274
SER A 406
LYS A  67
 None
None
BR  A 504 (-4.0A)
 1.19A 3aocC-4tm3A:
undetectable		 3aocC-4tm3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 TYR A 346
LEU A  56
GLU A 212
ARG A 104
HIS A  51
 FAD  A 501 ( 4.3A)
None
None
FAD  A 501 ( 4.2A)
FAD  A 501 (-3.7A)
 1.39A 3apvA-4tm3A:
undetectable		 3apvA-4tm3A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 TYR A 346
LEU A  56
GLU A 212
ARG A 104
HIS A  51
 FAD  A 501 ( 4.3A)
None
None
FAD  A 501 ( 4.2A)
FAD  A 501 (-3.7A)
 1.34A 3apvB-4tm3A:
undetectable		 3apvB-4tm3A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 11 ILE A 131
VAL A  17
PHE A  42
VAL A 128
HIS A  12
 None
None
None
FAD  A 501 (-4.0A)
None
 1.32A 3rf4A-4tm3A:
undetectable
3rf4C-4tm3A:
undetectable		 3rf4A-4tm3A:
13.32
3rf4C-4tm3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 11 HIS A  12
ILE A 131
VAL A  17
PHE A  42
VAL A 128
 None
None
None
None
FAD  A 501 (-4.0A)
 1.35A 3rf4A-4tm3A:
undetectable
3rf4B-4tm3A:
undetectable		 3rf4A-4tm3A:
13.32
3rf4B-4tm3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 11 HIS A  12
ILE A 131
VAL A  17
PHE A  42
VAL A 128
 None
None
None
None
FAD  A 501 (-4.0A)
 1.31A 3rf4B-4tm3A:
undetectable
3rf4C-4tm3A:
undetectable		 3rf4B-4tm3A:
13.32
3rf4C-4tm3A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 11 LEU A  24
ALA A  22
LEU A 405
LEU A 408
HIS A 108
 None
FAD  A 501 (-3.2A)
BR  A 505 ( 4.0A)
None
None
 1.35A 4zn7B-4tm3A:
undetectable		 4zn7B-4tm3A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 PHE A 257
GLY A 387
ILE A 388
GLY A 392
GLY A 393
 None
 0.76A 5koxA-4tm3A:
4.4		 5koxA-4tm3A:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4tm3 KTZI
(Kutzneria
sp.
744) 		4 / 4 ASN A 240
SER A 277
ALA A 238
VAL A 237
 None
 1.39A 5nm5A-4tm3A:
2.3		 5nm5A-4tm3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 THR A 224
VAL A 201
VAL A 339
ASP A 219
PHE A 186
 None
 1.40A 6iblA-4tm3A:
2.2		 6iblA-4tm3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 THR A 224
VAL A 339
ASP A 219
TRP A 181
PHE A 186
 None
 1.17A 6iblA-4tm3A:
2.2		 6iblA-4tm3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 THR A 224
VAL A 201
VAL A 339
ASP A 219
PHE A 186
 None
 1.40A 6iblB-4tm3A:
2.2		 6iblB-4tm3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 4tm3 KTZI
(Kutzneria
sp.
744) 		5 / 12 THR A 224
VAL A 339
ASP A 219
TRP A 181
PHE A 186
 None
 1.19A 6iblB-4tm3A:
2.2		 6iblB-4tm3A:
21.78