SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		4 / 6 LEU A  63
TRP A  84
TYR A  11
VAL A  45
 None
 1.04A 1ibgH-4tm5A:
undetectable		 1ibgH-4tm5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 LEU A  23
VAL A  10
PHE A 131
ALA A 105
ALA A 134
 None
 1.34A 1q23A-4tm5A:
undetectable
1q23B-4tm5A:
undetectable		 1q23A-4tm5A:
19.61
1q23B-4tm5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  47
ALA A 134
LEU A  87
LEU A  63
VAL A  45
 None
 1.06A 3ix9A-4tm5A:
undetectable		 3ix9A-4tm5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 ILE A  47
ALA A 134
LEU A  87
LEU A  63
VAL A  45
 None
 0.98A 3ix9B-4tm5A:
undetectable		 3ix9B-4tm5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		4 / 6 SER A  13
GLU A  18
ASP A  39
ARG A 113
 None
 0.80A 5cdnC-4tm5A:
undetectable
5cdnD-4tm5A:
undetectable		 5cdnC-4tm5A:
20.20
5cdnD-4tm5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		4 / 6 SER A  13
GLU A  18
ASP A  39
ARG A 113
 None
 0.79A 5cdnT-4tm5A:
undetectable
5cdnU-4tm5A:
undetectable		 5cdnT-4tm5A:
20.20
5cdnU-4tm5A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		4 / 5 HIS A 178
HIS A 182
VAL A 152
ALA A 154
 None
 1.13A 5i3bB-4tm5A:
undetectable		 5i3bB-4tm5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 223
GLU A 235
ALA A 242
ILE A 265
TYR A 292
 LLP  A 165 ( 3.4A)
None
None
None
None
 1.26A 5igvA-4tm5A:
undetectable		 5igvA-4tm5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4tm5 D-AMINO ACID
AMINOTRANSFERASE
(Burkholderia
thailandensis) 		3 / 3 HIS A  62
ARG A 225
ILE A 224
 LLP  A 165 ( 4.8A)
LLP  A 165 ( 4.0A)
LLP  A 165 ( 3.7A)
 0.79A 6fgdA-4tm5A:
undetectable		 6fgdA-4tm5A:
21.30