SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 7 ARG B 731
ASP B 553
ASP B 549
TYR B 535
 None
 1.25A 1ceaB-4tmaB:
undetectable		 1ceaB-4tmaB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 4 THR B 753
GLY B 741
ASP B 498
ALA B 428
 None
 0.89A 1sg9A-4tmaB:
undetectable		 1sg9A-4tmaB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 LEU B 580
VAL B 584
ILE B 707
LEU B 726
TYR B 611
 None
 1.11A 2qk8A-4tmaB:
undetectable		 2qk8A-4tmaB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 LEU B 509
THR B 508
PHE B 777
LEU B 780
 None
 1.03A 2wm3A-4tmaB:
undetectable		 2wm3A-4tmaB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 LEU B 580
VAL B 584
ILE B 707
LEU B 726
TYR B 611
 None
 1.06A 3datA-4tmaB:
undetectable		 3datA-4tmaB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 LEU B 580
VAL B 584
ILE B 707
LEU B 726
TYR B 611
 None
 1.12A 3fl9B-4tmaB:
undetectable		 3fl9B-4tmaB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 LEU B 580
VAL B 584
ILE B 707
LEU B 726
TYR B 611
 None
 1.15A 3fl9G-4tmaB:
undetectable		 3fl9G-4tmaB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 MET B 552
LEU B 583
ILE B 736
ILE B 559
 None
 0.90A 3gcsA-4tmaB:
undetectable		 3gcsA-4tmaB:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		5 / 12 ILE B 443
GLY B 429
ALA B 428
SER B 427
LEU B 742
 None
 1.05A 3n8xA-4tmaB:
undetectable		 3n8xA-4tmaB:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 5 TRP B 725
GLY B 710
ALA B 564
PHE B 706
 None
 1.13A 3wqwA-4tmaB:
undetectable		 3wqwA-4tmaB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4tma DNA GYRASE SUBUNIT B
DNA GYRASE INHIBITOR
YACG
(Escherichia
coli;
Escherichia
coli) 		3 / 3 SER I  50
ASP B 502
ASP B 426
 None
ZN  B1001 (-3.3A)
None
 0.87A 4mwzA-4tmaI:
undetectable		 4mwzA-4tmaI:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 LYS B 487
GLY B 475
TYR B 490
ALA B 473
 None
 1.18A 4yshB-4tmaB:
undetectable		 4yshB-4tmaB:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		3 / 3 VAL B 666
TYR B 675
GLU B 641
 None
 0.94A 5zmqD-4tmaB:
undetectable
5zmqE-4tmaB:
undetectable		 5zmqD-4tmaB:
17.73
5zmqE-4tmaB:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 7 SER B 504
HIS B 505
GLY B 503
LEU B 776
 None
 1.12A 6btxA-4tmaB:
undetectable		 6btxA-4tmaB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4tma DNA GYRASE SUBUNIT B
(Escherichia
coli) 		4 / 6 PRO B 613
GLN B 612
ARG B 698
ILE B 610
 None
 1.44A 6ef6A-4tmaB:
undetectable		 6ef6A-4tmaB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4tma DNA GYRASE INHIBITOR
YACG
DNA GYRASE SUBUNIT B
(Escherichia
coli) 		3 / 3 TRP I  18
GLU I  20
GLU B 520
 None
 0.87A 6fhwA-4tmaI:
undetectable		 6fhwA-4tmaI:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4tma DNA GYRASE SUBUNIT B
DNA GYRASE INHIBITOR
YACG
(Escherichia
coli;
Escherichia
coli) 		4 / 7 ARG B 516
TYR B 515
ASP I  36
GLU I  39
 None
 1.12A 6mn5E-4tmaB:
undetectable		 6mn5E-4tmaB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4tma DNA GYRASE SUBUNIT B
DNA GYRASE INHIBITOR
YACG
(Escherichia
coli;
Escherichia
coli) 		4 / 7 ASP B 774
ARG B 516
ASP I  36
GLU I  39
 None
 1.27A 6mn5E-4tmaB:
undetectable		 6mn5E-4tmaB:
17.56