SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 THR A  37
TYR A  82
HIS A 191
GLN A 121
TYR A 375
 FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 4.0A)
 1.33A 1h60A-4tmcA:
48.9		 1h60A-4tmcA:
39.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H60_A_STRA500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 THR A  37
TYR A  82
HIS A 191
TYR A 196
TYR A 375
 FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 3.7A)
HBA  A 502 (-4.5A)
FMN  A 501 ( 4.0A)
 0.87A 1h60A-4tmcA:
48.9		 1h60A-4tmcA:
39.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 6 LYS A 179
LEU A  94
ALA A 180
VAL A 188
 None
 1.10A 1sn5A-4tmcA:
undetectable		 1sn5A-4tmcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 5 GLN A 168
TRP A  89
GLU A 172
LEU A 127
 None
 1.50A 1ulvA-4tmcA:
undetectable		 1ulvA-4tmcA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		3 / 3 ASP A 370
TYR A 369
GLU A 399
 None
 0.81A 1vm1A-4tmcA:
undetectable		 1vm1A-4tmcA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 THR A  37
TYR A  82
HIS A 191
GLN A 121
TYR A 375
 FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 4.0A)
 1.35A 2abaA-4tmcA:
48.9		 2abaA-4tmcA:
39.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ABA_A_STRA1500_1
(PENTAERYTHRITOL
TETRANITRATE
REDUCTASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 THR A  37
TYR A  82
HIS A 191
TYR A 196
TYR A 375
 FMN  A 501 ( 3.7A)
None
FMN  A 501 ( 3.7A)
HBA  A 502 (-4.5A)
FMN  A 501 ( 4.0A)
 0.84A 2abaA-4tmcA:
48.9		 2abaA-4tmcA:
39.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 THR A 383
ILE A  68
VAL A 111
HIS A 105
ALA A  53
 None
 1.31A 2g72B-4tmcA:
undetectable		 2g72B-4tmcA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 7 SER A 391
ARG A 359
TYR A 396
TYR A   3
 None
 1.49A 2vmyA-4tmcA:
undetectable
2vmyB-4tmcA:
undetectable		 2vmyA-4tmcA:
22.94
2vmyB-4tmcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 7 VAL A 174
LYS A 178
ILE A 181
GLY A 184
 None
 0.85A 3bjwH-4tmcA:
undetectable		 3bjwH-4tmcA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 SER A 241
THR A 240
GLY A 187
ILE A  68
LEU A 115
 None
 1.25A 3fzgA-4tmcA:
undetectable		 3fzgA-4tmcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 11 GLN A  62
TYR A 346
ALA A 333
LEU A  27
PHE A  17
 None
 1.37A 3jwqA-4tmcA:
undetectable
3jwqD-4tmcA:
undetectable		 3jwqA-4tmcA:
21.16
3jwqD-4tmcA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 LEU A 132
ILE A 161
ILE A 166
GLN A 168
GLU A 165
 None
 1.22A 3tmzA-4tmcA:
undetectable		 3tmzA-4tmcA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 THR A  37
HIS A 191
TYR A 196
PHE A 250
TYR A 375
 FMN  A 501 ( 3.7A)
FMN  A 501 ( 3.7A)
HBA  A 502 (-4.5A)
None
FMN  A 501 ( 4.0A)
 0.34A 3upwA-4tmcA:
58.4		 3upwA-4tmcA:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 6 TYR A 375
ARG A  40
ASP A 370
TYR A 382
 FMN  A 501 ( 4.0A)
None
None
None
 1.24A 3wfaA-4tmcA:
7.9
3wfaB-4tmcA:
undetectable		 3wfaA-4tmcA:
21.58
3wfaB-4tmcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 8 TYR A 142
THR A 138
TYR A 134
ARG A 209
 None
 1.48A 3wipB-4tmcA:
undetectable
3wipC-4tmcA:
undetectable		 3wipB-4tmcA:
21.29
3wipC-4tmcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 8 TYR A 142
THR A 138
TYR A 134
ARG A 209
 None
 1.48A 3wipC-4tmcA:
undetectable
3wipD-4tmcA:
undetectable		 3wipC-4tmcA:
21.29
3wipD-4tmcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 8 TYR A 142
THR A 138
TYR A 134
ARG A 209
 None
 1.50A 3wipD-4tmcA:
undetectable
3wipE-4tmcA:
undetectable		 3wipD-4tmcA:
21.29
3wipE-4tmcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 8 ARG A 209
TYR A 142
THR A 138
TYR A 134
 None
 1.49A 3wipA-4tmcA:
undetectable
3wipE-4tmcA:
undetectable		 3wipA-4tmcA:
21.29
3wipE-4tmcA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		6 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 FMN  A 501 ( 3.7A)
HBA  A 502 (-4.3A)
FMN  A 501 ( 3.7A)
HBA  A 502 ( 3.6A)
HBA  A 502 (-4.5A)
FMN  A 501 ( 4.0A)
 0.28A 4a3uA-4tmcA:
48.4		 4a3uA-4tmcA:
36.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		6 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
TYR A 375
 FMN  A 501 ( 3.7A)
HBA  A 502 (-4.3A)
FMN  A 501 ( 3.7A)
HBA  A 502 ( 3.6A)
HBA  A 502 (-4.5A)
FMN  A 501 ( 4.0A)
 0.27A 4a3uB-4tmcA:
48.5		 4a3uB-4tmcA:
36.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 7 TYR A 358
ASP A 355
SER A 387
TYR A   3
 None
 1.29A 4arcA-4tmcA:
undetectable		 4arcA-4tmcA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 7 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
 FMN  A 501 ( 3.7A)
HBA  A 502 (-4.3A)
FMN  A 501 ( 3.7A)
HBA  A 502 ( 3.6A)
HBA  A 502 (-4.5A)
 0.36A 4awuA-4tmcA:
49.0		 4awuA-4tmcA:
37.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 6 THR A  37
HIS A 191
TYR A 196
TYR A 375
 FMN  A 501 ( 3.7A)
FMN  A 501 ( 3.7A)
HBA  A 502 (-4.5A)
FMN  A 501 ( 4.0A)
 0.21A 4df2A-4tmcA:
58.3		 4df2A-4tmcA:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 ALA A 193
SER A 206
ILE A 205
PRO A 204
ASN A 258
 None
 1.21A 4gh8B-4tmcA:
undetectable		 4gh8B-4tmcA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 7 LEU A 287
VAL A 288
PRO A 290
TYR A 313
 None
FMN  A 501 ( 4.4A)
None
None
 0.95A 4lb2A-4tmcA:
undetectable		 4lb2A-4tmcA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 5 TYR A 369
THR A 334
LEU A  11
MET A  33
 None
 1.29A 4mbsB-4tmcA:
undetectable		 4mbsB-4tmcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 7 PHE A   6
ALA A 327
ILE A 344
LEU A  11
 None
 1.11A 4uymB-4tmcA:
undetectable		 4uymB-4tmcA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 9 ALA A 327
LEU A 366
ASN A 367
LEU A 356
ARG A  60
 None
 1.49A 4x30A-4tmcA:
undetectable		 4x30A-4tmcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 8 ILE A  68
VAL A 111
GLN A 114
GLU A  71
 None
None
FMN  A 501 (-3.0A)
None
 0.81A 5dqyA-4tmcA:
undetectable		 5dqyA-4tmcA:
12.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		8 / 8 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 FMN  A 501 ( 3.7A)
HBA  A 502 (-4.3A)
FMN  A 501 ( 3.7A)
HBA  A 502 ( 3.6A)
HBA  A 502 (-4.5A)
None
None
FMN  A 501 ( 4.0A)
 0.34A 5v4vA-4tmcA:
71.3		 5v4vA-4tmcA:
67.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		8 / 8 THR A  37
TRP A 116
HIS A 191
ASN A 194
TYR A 196
PHE A 250
PRO A 295
TYR A 375
 FMN  A 501 ( 3.7A)
HBA  A 502 (-4.3A)
FMN  A 501 ( 3.7A)
HBA  A 502 ( 3.6A)
HBA  A 502 (-4.5A)
None
None
FMN  A 501 ( 4.0A)
 0.35A 5v4vB-4tmcA:
71.3		 5v4vB-4tmcA:
67.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 249
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.24A 5x6yA-4tmcA:
undetectable		 5x6yA-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 293
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.27A 5x6yA-4tmcA:
undetectable		 5x6yA-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 249
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.12A 5x6yC-4tmcA:
undetectable		 5x6yC-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 GLY A 248
ALA A 193
HIS A 191
GLU A 257
THR A 293
 None
None
FMN  A 501 ( 3.7A)
None
None
 1.27A 5x6yC-4tmcA:
undetectable		 5x6yC-4tmcA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		3 / 3 LYS A 339
PRO A 340
LYS A 317
 None
 1.26A 5y9yA-4tmcA:
undetectable		 5y9yA-4tmcA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 10 VAL A 111
HIS A 105
PHE A 101
THR A  73
VAL A 113
 None
 1.42A 6aogA-4tmcA:
undetectable		 6aogA-4tmcA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 10 VAL A 111
HIS A 105
PHE A 101
THR A  73
VAL A 113
 None
 1.43A 6aogB-4tmcA:
undetectable		 6aogB-4tmcA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 ILE A 166
ASN A 207
PHE A 201
GLY A 160
LEU A 197
 None
 1.14A 6dwnC-4tmcA:
undetectable		 6dwnC-4tmcA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		5 / 12 ILE A 166
ASN A 207
PHE A 201
GLY A 160
LEU A 197
 None
 1.11A 6dwnD-4tmcA:
undetectable		 6dwnD-4tmcA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		3 / 3 TYR A  63
HIS A  29
PHE A  17
 None
 1.06A 6esmA-4tmcA:
undetectable		 6esmA-4tmcA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		3 / 3 TYR A 326
ASP A 329
GLN A 332
 None
 0.85A 6g1pA-4tmcA:
undetectable		 6g1pA-4tmcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4tmc OLD YELLOW ENZYME
(Kluyveromyces
marxianus) 		4 / 6 PRO A  48
TRP A  97
TYR A  57
GLU A  54
 None
 1.06A 6gqiA-4tmcA:
undetectable		 6gqiA-4tmcA:
20.54