SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 8 PRO A 133
GLY A  98
LEU A 128
PHE A 131
 None
 0.81A 1h4oG-4tmkA:
undetectable		 1h4oG-4tmkA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		3 / 3 ASP A  56
GLU A  12
ARG A 113
 None
T5A  A 214 (-3.7A)
None
 0.79A 1wopA-4tmkA:
undetectable		 1wopA-4tmkA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 7 PRO A 133
GLY A  98
LEU A 128
PHE A 131
 None
 0.82A 2vl2B-4tmkA:
undetectable		 2vl2B-4tmkA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 4 LEU A 147
GLY A 146
LEU A  11
GLU A  12
 None
None
None
T5A  A 214 (-3.7A)
 1.04A 3tgvB-4tmkA:
undetectable		 3tgvB-4tmkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 5 GLY A  42
THR A  44
ILE A  86
VAL A  85
 None
 0.90A 3wriA-4tmkA:
undetectable		 3wriA-4tmkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		4 / 5 GLY A  42
THR A  44
ILE A  86
VAL A  85
 None
 0.88A 3wriB-4tmkA:
undetectable		 3wriB-4tmkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		5 / 12 ILE A 200
VAL A  23
LEU A  27
TRP A  95
LEU A 137
 None
 1.25A 4m11C-4tmkA:
undetectable		 4m11C-4tmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 4tmk PROTEIN (THYMIDYLATE
KINASE)
(Escherichia
coli) 		5 / 12 ILE A 200
THR A 203
THR A  26
LEU A 137
LEU A 135
 None
 1.43A 4pbhA-4tmkA:
undetectable		 4pbhA-4tmkA:
22.49