SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 9 LEU A 196
LEU A 126
ILE A  69
VAL A 175
PHE A 172
 None
 1.46A 1gx8A-4tmuA:
undetectable		 1gx8A-4tmuA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 8 VAL A  90
LEU A 118
TYR A  57
SER A  54
 None
 1.15A 1jtvA-4tmuA:
2.3		 1jtvA-4tmuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 4 LEU A  85
ILE A 121
ARG A 125
TYR A  57
 None
 1.20A 1rk3A-4tmuA:
undetectable		 1rk3A-4tmuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4tmu RECQ
(Cronobacter
sakazakii) 		3 / 3 SER A 277
HIS A 267
ASP A 251
 None
 0.85A 2oxtA-4tmuA:
2.3		 2oxtA-4tmuA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 10 LEU A 420
LEU A 510
LEU A 479
VAL A 481
SER A 471
 None
 1.09A 2w9hA-4tmuA:
undetectable		 2w9hA-4tmuA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 5 LEU A  85
ILE A 121
ARG A 125
TYR A  57
 None
 1.20A 2zlcA-4tmuA:
undetectable		 2zlcA-4tmuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 12 LEU A 420
ALA A 497
LEU A 479
HIS A 478
THR A 495
 None
 1.11A 3dfrA-4tmuA:
undetectable		 3dfrA-4tmuA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 8 TYR A 340
ALA A 343
ALA A 346
LEU A 368
 None
 0.96A 3l4dA-4tmuA:
undetectable		 3l4dA-4tmuA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 12 GLY A  52
GLY A  50
PHE A  26
SER A  54
GLN A  58
 None
 1.41A 3tkaA-4tmuA:
undetectable		 3tkaA-4tmuA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 7 HIS A 149
ILE A 151
TYR A 162
PRO A  73
 None
 1.18A 4g5jA-4tmuA:
undetectable		 4g5jA-4tmuA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 10 LEU A 287
PHE A 282
VAL A 278
ILE A 240
ALA A 253
 None
 0.95A 4j14A-4tmuA:
undetectable		 4j14A-4tmuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 12 ASP A 453
HIS A 452
TYR A 458
ASN A 444
TYR A 434
 None
 1.43A 4ypaD-4tmuA:
undetectable		 4ypaD-4tmuA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 12 ILE A 213
GLY A 325
ILE A 317
PHE A 374
TYR A 320
 None
 1.38A 5igwA-4tmuA:
undetectable		 5igwA-4tmuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4tmu RECQ
(Cronobacter
sakazakii) 		3 / 3 GLY A 398
CYH A 403
CYH A 400
 ZN  A 601 ( 4.9A)
ZN  A 601 (-2.3A)
ZN  A 601 (-2.3A)
 0.96A 5inzB-4tmuA:
undetectable		 5inzB-4tmuA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 4tmu RECQ
(Cronobacter
sakazakii) 		5 / 12 VAL A 472
LEU A 479
LEU A 420
ILE A 423
ALA A 419
 None
 1.49A 5xprA-4tmuA:
undetectable		 5xprA-4tmuA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4tmu RECQ
(Cronobacter
sakazakii) 		4 / 4 HIS A 267
VAL A 274
LEU A 270
ALA A 265
 None
 1.31A 6d8pB-4tmuA:
3.9		 6d8pB-4tmuA:
22.34