SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4tmz EIF5B
(Chaetomium
thermophilum) 		3 / 3 GLU B 552
ILE B 556
ARG B 605
 MG  B 902 ( 3.9A)
GSP  B 901 (-4.2A)
None
 0.71A 1cd2A-4tmzB:
undetectable		 1cd2A-4tmzB:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 VAL B 767
LEU B 796
VAL B 817
LEU B 839
 None
 0.87A 1cqpA-4tmzB:
undetectable
1cqpB-4tmzB:
3.2		 1cqpA-4tmzB:
18.93
1cqpB-4tmzB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 6 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.45A 1nsiA-4tmzB:
undetectable
1nsiB-4tmzB:
undetectable		 1nsiA-4tmzB:
23.93
1nsiB-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 6 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.48A 1nsiC-4tmzB:
undetectable
1nsiD-4tmzB:
undetectable		 1nsiC-4tmzB:
23.93
1nsiD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 6 PHE B 695
GLU B 692
ARG B 637
ILE B 630
 None
 1.48A 1nsiC-4tmzB:
undetectable
1nsiD-4tmzB:
undetectable		 1nsiC-4tmzB:
23.93
1nsiD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 LEU B 529
LEU B 617
ALA B 646
LEU B 733
CYH B 526
 None
 1.15A 1ya3C-4tmzB:
undetectable		 1ya3C-4tmzB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 10 GLY B 589
LEU B 590
ILE B 592
LEU B 727
ILE B 570
 None
 1.05A 2f8dB-4tmzB:
undetectable		 2f8dB-4tmzB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.42A 2nsiA-4tmzB:
undetectable
2nsiB-4tmzB:
undetectable		 2nsiA-4tmzB:
23.93
2nsiB-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 PHE B 695
GLU B 692
ARG B 637
ILE B 630
 None
 1.45A 2nsiA-4tmzB:
undetectable
2nsiB-4tmzB:
undetectable		 2nsiA-4tmzB:
23.93
2nsiB-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.44A 2nsiC-4tmzB:
undetectable
2nsiD-4tmzB:
undetectable		 2nsiC-4tmzB:
23.93
2nsiD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 PHE B 695
GLU B 692
ARG B 637
ILE B 630
 None
 1.44A 2nsiC-4tmzB:
undetectable
2nsiD-4tmzB:
undetectable		 2nsiC-4tmzB:
23.93
2nsiD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 LEU B 617
LEU B 633
GLN B 693
VAL B 686
THR B 534
 None
None
None
None
GSP  B 901 (-4.3A)
 1.43A 2yloA-4tmzB:
undetectable		 2yloA-4tmzB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.46A 3e7gA-4tmzB:
undetectable
3e7gB-4tmzB:
undetectable		 3e7gA-4tmzB:
23.93
3e7gB-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 PHE B 695
GLU B 692
ARG B 637
ILE B 630
 None
 1.48A 3e7gA-4tmzB:
undetectable
3e7gB-4tmzB:
undetectable		 3e7gA-4tmzB:
23.93
3e7gB-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 7 ARG B 637
ILE B 630
PHE B 695
GLU B 692
 None
 1.47A 3e7gC-4tmzB:
undetectable
3e7gD-4tmzB:
undetectable		 3e7gC-4tmzB:
23.93
3e7gD-4tmzB:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 6 ILE B 780
VAL B 841
LEU B 748
LEU B 769
 None
 0.90A 3kp6A-4tmzB:
undetectable
3kp6B-4tmzB:
undetectable		 3kp6A-4tmzB:
20.25
3kp6B-4tmzB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 8 ILE B 560
SER B 610
SER B 606
GLY B 608
ASN B 603
 None
 1.27A 3lslA-4tmzB:
undetectable
3lslD-4tmzB:
undetectable		 3lslA-4tmzB:
21.65
3lslD-4tmzB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 GLU B 552
GLY B 561
GLU B 804
ASP B 766
GLN B 559
 MG  B 902 ( 3.9A)
None
None
None
None
 1.30A 3nmuA-4tmzB:
undetectable
3nmuF-4tmzB:
2.8		 3nmuA-4tmzB:
23.56
3nmuF-4tmzB:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 11 ILE B 780
LEU B 839
THR B 751
VAL B 767
LEU B 774
 None
 1.13A 4g1bB-4tmzB:
2.6		 4g1bB-4tmzB:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 ILE B 780
GLN B 749
LEU B 839
VAL B 767
LEU B 774
 None
 1.14A 4g1bD-4tmzB:
2.6		 4g1bD-4tmzB:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 ILE B 780
LEU B 839
THR B 751
VAL B 767
LEU B 774
 None
 1.15A 4g1bD-4tmzB:
2.6		 4g1bD-4tmzB:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 9 ILE B 528
GLY B 530
THR B 629
LEU B 636
LEU B 633
 None
 1.35A 5fhzB-4tmzB:
undetectable		 5fhzB-4tmzB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 ALA B 562
GLY B 561
ASN B 547
GLN B 549
GLU B 550
 None
None
None
GSP  B 901 (-3.9A)
None
 1.20A 5nwuA-4tmzB:
undetectable		 5nwuA-4tmzB:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 5 LEU B 729
VAL B 644
CYH B 734
CYH B 526
 None
 1.46A 5te0A-4tmzB:
undetectable		 5te0A-4tmzB:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4tmz EIF5B
(Chaetomium
thermophilum) 		5 / 12 PHE B 643
LEU B 625
ILE B 630
SER B 609
PHE B 695
 CL  B 905 (-4.3A)
None
None
None
None
 1.41A 5uanB-4tmzB:
undetectable		 5uanB-4tmzB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 4tmz EIF5B
(Chaetomium
thermophilum) 		4 / 6 GLN B 735
MET B 726
VAL B 731
LEU B 727
 None
 1.12A 5xdhA-4tmzB:
undetectable
5xdhC-4tmzB:
undetectable		 5xdhA-4tmzB:
11.70
5xdhC-4tmzB:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4tmz EIF5B
(Chaetomium
thermophilum) 		3 / 3 TYR B 811
HIS B 813
PHE B 761
 None
 0.99A 6esmA-4tmzB:
undetectable		 6esmA-4tmzB:
14.98