SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Macaca
mulatta;
Escherichia
virus
T4) 		4 / 7 LEU A 336
LEU A 318
GLY A 331
LEU A 369
 None
 0.92A 1gtiA-4tn3A:
undetectable		 1gtiA-4tn3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Macaca
mulatta;
Escherichia
virus
T4) 		5 / 12 ALA A 366
GLY A 331
GLY A 333
ASP A 364
GLY A 354
 None
 1.02A 1sqfA-4tn3A:
undetectable		 1sqfA-4tn3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Escherichia
virus
T4;
Macaca
mulatta) 		4 / 8 THR A 337
TYR A 328
ILE A 320
SER A 339
 None
 1.10A 2xytE-4tn3A:
undetectable		 2xytE-4tn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Escherichia
virus
T4;
Macaca
mulatta) 		4 / 8 THR A 337
TYR A 328
ILE A 320
SER A 339
 None
 1.06A 2xytH-4tn3A:
undetectable		 2xytH-4tn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Escherichia
virus
T4;
Macaca
mulatta) 		4 / 7 THR A 337
TYR A 328
ILE A 320
SER A 339
 None
 1.09A 2xytI-4tn3A:
undetectable		 2xytI-4tn3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Escherichia
virus
T4;
Macaca
mulatta) 		3 / 3 GLU A 197
TRP A 196
LYS A 278
 None
 1.11A 4k7aA-4tn3A:
undetectable		 4k7aA-4tn3A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Macaca
mulatta;
Escherichia
virus
T4) 		5 / 12 TYR A 464
ILE A 306
MET A 304
ASN A 404
PHE A 407
 None
 1.30A 4obwD-4tn3A:
undetectable		 4obwD-4tn3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA
(Macaca
mulatta;
Escherichia
virus
T4) 		4 / 7 THR A 329
TYR A 321
GLU A 314
HIS A 334
 None
 1.14A 5ecnA-4tn3A:
undetectable		 5ecnA-4tn3A:
20.03