SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 9 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.43A 1fo4A-4tn5A:
undetectable		 1fo4A-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 11 LEU A  49
GLU A  38
ALA A  20
ARG A  73
PHE A  74
 None
 1.02A 1l5rA-4tn5A:
3.1		 1l5rA-4tn5A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 10 LEU A 110
THR A 108
VAL A 101
LEU A  61
VAL A   5
 None
 1.37A 3tbgC-4tn5A:
undetectable		 3tbgC-4tn5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 9 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.40A 3unaA-4tn5A:
undetectable		 3unaA-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 9 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.41A 3unaB-4tn5A:
undetectable		 3unaB-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 9 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.39A 3uncA-4tn5A:
undetectable		 3uncA-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 9 LEU A  49
ARG A  56
VAL A  35
LEU A   4
ALA A  57
 None
 1.40A 3uncB-4tn5A:
undetectable		 3uncB-4tn5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		4 / 8 TYR A  18
THR A  45
ARG A  48
LEU A  49
 None
 0.94A 3wipG-4tn5A:
undetectable
3wipH-4tn5A:
undetectable		 3wipG-4tn5A:
18.50
3wipH-4tn5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		4 / 8 ARG A  48
LEU A  49
TYR A  18
THR A  45
 None
 0.95A 3wipF-4tn5A:
undetectable
3wipJ-4tn5A:
undetectable		 3wipF-4tn5A:
18.50
3wipJ-4tn5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		5 / 12 VAL A  80
THR A  64
ILE A  54
VAL A   5
ILE A  37
 None
 1.44A 4eb6B-4tn5A:
2.5
4eb6C-4tn5A:
undetectable		 4eb6B-4tn5A:
13.54
4eb6C-4tn5A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		3 / 3 GLY A  44
GLU A  38
THR A  39
 None
 0.56A 4kouA-4tn5A:
undetectable		 4kouA-4tn5A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		4 / 5 LEU A  62
LEU A   4
PHE A  74
LEU A  49
 None
 1.05A 5gtrA-4tn5A:
undetectable		 5gtrA-4tn5A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4tn5 FRUCTOSE-LIKE
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT
3
(Escherichia
coli) 		4 / 7 GLN A  40
GLY A  70
ILE A  54
GLN A 107
 None
 1.11A 5vlmC-4tn5A:
undetectable		 5vlmC-4tn5A:
24.87