SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tnb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 GLY A  21
GLY A  20
HIS A 324
VAL A 466
 None
 0.91A 1dbbH-4tnbA:
undetectable
1dbbL-4tnbA:
undetectable		 1dbbH-4tnbA:
17.46
1dbbL-4tnbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 7 VAL A 247
MET A 266
ARG A 310
LEU A 318
 None
None
None
SGV  A 601 (-4.9A)
 0.97A 1iepB-4tnbA:
17.3		 1iepB-4tnbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
MET A 266
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.71A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.98A 1m17A-4tnbA:
22.6		 1m17A-4tnbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 ARG A 388
ASP A 270
ASN A 267
 None
SGV  A 601 (-4.2A)
None
 0.91A 1nbhA-4tnbA:
undetectable		 1nbhA-4tnbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 ARG A 388
ASP A 270
ASN A 267
 None
SGV  A 601 (-4.2A)
None
 0.89A 1nbhD-4tnbA:
undetectable		 1nbhD-4tnbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
VAL A 247
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
SGV  A 601 (-4.9A)
 0.92A 1t46A-4tnbA:
20.0		 1t46A-4tnbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A 192
ALA A 213
LEU A 263
ASP A 270
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
SGV  A 601 (-4.9A)
 0.77A 1yi4A-4tnbA:
23.6		 1yi4A-4tnbA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.93A 2avvE-4tnbA:
undetectable		 2avvE-4tnbA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 PHE A 502
LEU A 217
LEU A 263
LEU A 238
 None
None
SGV  A 601 (-4.5A)
None
 0.91A 2bfpD-4tnbA:
undetectable		 2bfpD-4tnbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.97A 2f81B-4tnbA:
undetectable		 2f81B-4tnbA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.97A 2ienB-4tnbA:
undetectable		 2ienB-4tnbA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
SGV  A 601 (-3.0A)
 0.83A 2ityA-4tnbA:
17.9		 2ityA-4tnbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.91A 2nmyB-4tnbA:
undetectable		 2nmyB-4tnbA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 5 LEU A 371
ILE A 317
GLY A 298
HIS A 303
 None
 0.92A 2otfA-4tnbA:
undetectable		 2otfA-4tnbA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.85A 2rkfA-4tnbA:
undetectable		 2rkfA-4tnbA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.86A 2rkgB-4tnbA:
undetectable		 2rkgB-4tnbA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.63A 2xp2A-4tnbA:
7.9		 2xp2A-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 ARG A 190
LEU A 192
ALA A 213
LEU A 263
MET A 266
GLY A 268
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
None
SGV  A 601 (-4.9A)
 1.18A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 ARG A 190
LEU A 192
ALA A 213
VAL A 247
LEU A 263
MET A 266
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.86A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 LEU A 192
ALA A 213
LYS A 215
VAL A 247
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.78A 3aoxA-4tnbA:
20.6		 3aoxA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 PRO A 354
GLY A 350
MET A 352
TRP A 369
 None
 1.38A 3aqiA-4tnbA:
undetectable		 3aqiA-4tnbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 PRO A 354
GLY A 350
MET A 352
TRP A 369
 None
 1.39A 3aqiB-4tnbA:
undetectable		 3aqiB-4tnbA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_2
(PHOSPHOLIPASE A2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 4 SER A 114
PRO A 115
PHE A 117
PRO A 112
 None
 1.43A 3bjwG-4tnbA:
0.0		 3bjwG-4tnbA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.95A 3cywB-4tnbA:
undetectable		 3cywB-4tnbA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.94A 3d20A-4tnbA:
undetectable		 3d20A-4tnbA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 1.05A 3ebzA-4tnbA:
undetectable		 3ebzA-4tnbA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.85A 3ekpB-4tnbA:
undetectable		 3ekpB-4tnbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.87A 3ekpC-4tnbA:
undetectable		 3ekpC-4tnbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.89A 3ekpD-4tnbA:
undetectable		 3ekpD-4tnbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.85A 3ektC-4tnbA:
undetectable		 3ektC-4tnbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.87A 3ektD-4tnbA:
undetectable		 3ektD-4tnbA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
MET A 266
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 1.43A 3hegA-4tnbA:
2.2		 3hegA-4tnbA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 ALA A 213
LYS A 215
GLU A 234
LEU A 261
 SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.28A 3lfaA-4tnbA:
20.7		 3lfaA-4tnbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.90A 3lzsA-4tnbA:
undetectable		 3lzsA-4tnbA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.91A 3lzsB-4tnbA:
undetectable		 3lzsB-4tnbA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.89A 3lzuA-4tnbA:
undetectable		 3lzuA-4tnbA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.95A 3mwsA-4tnbA:
undetectable		 3mwsA-4tnbA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.91A 3mwsB-4tnbA:
undetectable		 3mwsB-4tnbA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 9 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.92A 3nujB-4tnbA:
undetectable		 3nujB-4tnbA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.92A 3pwmA-4tnbA:
undetectable		 3pwmA-4tnbA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		8 / 12 LEU A 192
VAL A 200
ALA A 213
GLU A 234
VAL A 247
GLY A 269
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
None
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.93A 3qlgB-4tnbA:
20.9		 3qlgB-4tnbA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 GLY A 209
GLU A 514
VAL A 181
TYR A 212
PHE A 186
 None
 1.37A 3r6wA-4tnbA:
undetectable
3r6wB-4tnbA:
undetectable		 3r6wA-4tnbA:
15.57
3r6wB-4tnbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.96A 3s53B-4tnbA:
undetectable		 3s53B-4tnbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 9 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.88A 3s56B-4tnbA:
undetectable		 3s56B-4tnbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 9 PHE A 447
PHE A 448
VAL A 442
ILE A 375
GLY A 372
 None
 1.37A 3t3rB-4tnbA:
undetectable		 3t3rB-4tnbA:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 LEU A 263
MET A 266
ASP A 270
 SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.2A)
 0.23A 3v5wA-4tnbA:
13.4		 3v5wA-4tnbA:
33.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 8 VAL A 246
VAL A 247
LEU A 318
ILE A 327
 None
None
SGV  A 601 (-4.9A)
None
 0.69A 3wzeA-4tnbA:
16.8		 3wzeA-4tnbA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.65A 4anqA-4tnbA:
17.1		 4anqA-4tnbA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 238
LEU A 302
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.61A 4asdA-4tnbA:
20.1		 4asdA-4tnbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_1
(ASPARTYL PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.91A 4dqeA-4tnbA:
undetectable		 4dqeA-4tnbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 7 ILE A 118
LEU A 110
PHE A 142
GLY A 102
 None
 1.07A 4hbfA-4tnbA:
undetectable		 4hbfA-4tnbA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.89A 4hlaA-4tnbA:
undetectable		 4hlaA-4tnbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.89A 4hlaB-4tnbA:
undetectable		 4hlaB-4tnbA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 VAL A 200
ALA A 213
LEU A 263
ASP A 270
LEU A 318
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
SGV  A 601 (-4.9A)
 0.63A 4iaaA-4tnbA:
23.3		 4iaaA-4tnbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 11 VAL A 200
ALA A 213
LYS A 215
LEU A 263
ASP A 270
 SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.2A)
 0.42A 4iaaA-4tnbA:
23.3		 4iaaA-4tnbA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 249
LEU A 261
GLY A 269
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
None
None
SGV  A 601 (-4.9A)
 0.62A 4ifgA-4tnbA:
21.3		 4ifgA-4tnbA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 11 GLY A 193
VAL A 200
ALA A 213
LYS A 215
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.77A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 11 LEU A 192
GLY A 193
VAL A 200
ALA A 213
ASN A 316
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.69A 4o0sA-4tnbA:
23.2		 4o0sA-4tnbA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 LEU A 192
GLY A 193
VAL A 200
ALA A 213
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
 0.22A 4o0wA-4tnbA:
22.2		 4o0wA-4tnbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		9 / 12 LEU A 192
GLY A 193
GLY A 195
GLY A 198
VAL A 200
ALA A 213
LYS A 215
VAL A 247
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
None
None
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-3.0A)
 0.67A 4otiA-4tnbA:
23.2		 4otiA-4tnbA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 GLU A 377
PRO A 384
ILE A 325
TYR A 376
GLU A 406
 None
 1.43A 4rfqA-4tnbA:
0.0		 4rfqA-4tnbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_0
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 GLU A 377
PRO A 384
ILE A 325
TYR A 376
TYR A 351
 None
 1.41A 4rfqA-4tnbA:
0.0		 4rfqA-4tnbA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 LEU A  77
ILE A  81
LEU A 153
TYR A 152
 None
 0.87A 4w5nA-4tnbA:
undetectable		 4w5nA-4tnbA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 8 LEU A 192
ALA A 213
ILE A 265
LEU A 318
SER A 328
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-4.2A)
 0.41A 4wboB-4tnbA:
31.0		 4wboB-4tnbA:
44.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 6 ARG A 190
LEU A 192
ALA A 213
MET A 266
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
 0.77A 4wboC-4tnbA:
32.4		 4wboC-4tnbA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 9 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.75A 5aaaA-4tnbA:
16.3		 5aaaA-4tnbA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 10 LEU A 192
VAL A 200
ALA A 213
LYS A 215
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 1.04A 5aabA-4tnbA:
16.3		 5aabA-4tnbA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 10 LEU A 192
VAL A 200
ALA A 213
LEU A 263
MET A 266
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
None
SGV  A 601 (-4.9A)
 0.56A 5aacA-4tnbA:
21.1		 5aacA-4tnbA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 ARG A 190
LEU A 192
ALA A 213
LEU A 318
ASP A 329
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.59A 5h2uC-4tnbA:
19.8		 5h2uC-4tnbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 ASP A  85
ALA A  88
THR A 129
LYS A 132
GLY A 102
 None
 1.40A 5hfjC-4tnbA:
undetectable		 5hfjC-4tnbA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 7 GLY A 193
VAL A 200
LYS A 215
LEU A 217
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 ( 4.2A)
None
 0.48A 5izjA-4tnbA:
30.1		 5izjA-4tnbA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.93A 5kqyA-4tnbA:
undetectable		 5kqyA-4tnbA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 10 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 1.01A 5kr1A-4tnbA:
undetectable		 5kr1A-4tnbA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		3 / 3 LYS A  15
GLN A 512
ASN A 513
 None
 0.57A 5l2tA-4tnbA:
19.8		 5l2tA-4tnbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 11 GLY A 193
VAL A 200
ALA A 213
VAL A 247
LEU A 263
LEU A 318
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.50A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 11 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 263
LEU A 318
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 (-4.5A)
SGV  A 601 (-4.9A)
 0.39A 5lvnA-4tnbA:
27.5		 5lvnA-4tnbA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 GLY A 193
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 263
GLY A 269
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
SGV  A 601 (-4.5A)
None
 0.57A 5mafA-4tnbA:
26.8		 5mafA-4tnbA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		5 / 12 LEU A  45
ASP A  52
GLY A  63
ILE A  62
ILE A  49
 None
 0.90A 5t8hA-4tnbA:
undetectable		 5t8hA-4tnbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.99A 5vcvA-4tnbA:
23.0		 5vcvA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 261
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
None
 0.97A 5vcyA-4tnbA:
20.2		 5vcyA-4tnbA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		7 / 12 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.82A 5yu9A-4tnbA:
19.5		 5yu9A-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.74A 5yu9B-4tnbA:
19.7		 5yu9B-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		6 / 12 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
GLY A 268
 SGV  A 601 (-4.1A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
SGV  A 601 ( 4.2A)
None
None
 0.65A 5zv2B-4tnbA:
17.1		 5zv2B-4tnbA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens) 		4 / 6 ILE A 265
MET A 266
ASN A 267
ASP A 321
 None
 1.21A 6dhbA-4tnbA:
undetectable		 6dhbA-4tnbA:
10.97