SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 10 THR A 400
ALA A 399
ALA A 438
LEU A 381
VAL A 380
 None
 1.06A 1claA-4tnmA:
undetectable		 1claA-4tnmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		3 / 3 TRP A 379
LEU A 338
LYS A 347
 None
 0.94A 1yajK-4tnmA:
undetectable		 1yajK-4tnmA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		4 / 7 GLY A 203
ALA A 204
MET A 205
LEU A 208
 None
 0.66A 2wekB-4tnmA:
undetectable		 2wekB-4tnmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 CYH A 232
SER A 229
LEU A 228
THR A 225
THR A 243
 None
 1.15A 3a35A-4tnmA:
undetectable		 3a35A-4tnmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 CYH A 232
SER A 229
LEU A 228
THR A 225
THR A 243
 None
 1.14A 3a35B-4tnmA:
undetectable		 3a35B-4tnmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 CYH A 232
SER A 229
LEU A 228
THR A 225
THR A 243
 None
 1.18A 3a3bA-4tnmA:
undetectable		 3a3bA-4tnmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 9 LEU A  99
ILE A  84
GLY A  83
GLU A  94
LEU A  93
 None
 0.97A 3ai9X-4tnmA:
undetectable		 3ai9X-4tnmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 GLY A 186
GLY A 190
VAL A 199
THR A 227
LEU A 208
 None
 1.11A 3dh0B-4tnmA:
undetectable		 3dh0B-4tnmA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		3 / 3 ALA A 438
THR A 400
CYH A 416
 None
 0.78A 3e4eA-4tnmA:
undetectable		 3e4eA-4tnmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		3 / 3 ALA A 438
THR A 400
CYH A 416
 None
 0.71A 3e4eB-4tnmA:
undetectable		 3e4eB-4tnmA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 THR A 310
LEU A 262
GLN A 255
THR A 225
LEU A 295
 None
 1.44A 3fsuA-4tnmA:
undetectable		 3fsuA-4tnmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 ALA A 268
LEU A 253
LEU A 250
SER A 273
ALA A 224
 None
 1.46A 3lbdA-4tnmA:
undetectable		 3lbdA-4tnmA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 LEU A 250
GLY A 287
ALA A 286
ILE A 314
LEU A 247
 None
 1.07A 3ogqB-4tnmA:
undetectable		 3ogqB-4tnmA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		4 / 4 VAL A 303
THR A 263
GLU A 259
GLU A 260
 None
 1.33A 4l78A-4tnmA:
undetectable		 4l78A-4tnmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 12 VAL A 315
ALA A 330
VAL A 325
LEU A 338
ILE A 374
 None
 0.94A 5hv1A-4tnmA:
undetectable		 5hv1A-4tnmA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		3 / 3 ALA A 448
ASN A 451
LEU A 452
 None
 0.37A 5i1pA-4tnmA:
undetectable		 5i1pA-4tnmA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		4 / 7 SER A 160
PRO A 164
TYR A 202
PHE A 166
 None
 1.26A 5l1fC-4tnmA:
2.6		 5l1fC-4tnmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		5 / 11 ILE A 165
ASP A 130
VAL A 177
LEU A 143
THR A 144
 None
 1.40A 5tiyA-4tnmA:
undetectable		 5tiyA-4tnmA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4tnm IMPORTIN SUBUNIT
ALPHA
(Arabidopsis
thaliana) 		4 / 4 LEU A 326
ASP A 327
GLN A 329
VAL A 378
 None
 1.30A 6bzoF-4tnmA:
2.5		 6bzoF-4tnmA:
22.24