SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 8 PHE A 151
THR A 152
ILE A 156
HIS A  59
 None
None
None
REA  A 201 (-4.7A)
 0.80A 1ei6D-4tnsA:
undetectable		 1ei6D-4tnsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		4 / 5 SER A 138
MET A 130
PHE A 125
ILE A 159
 None
REA  A 201 (-2.9A)
None
None
 1.49A 3g59A-4tnsA:
undetectable		 3g59A-4tnsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		3 / 3 THR A 162
SER A  58
ASP A 102
 None
 0.78A 5kvaA-4tnsA:
undetectable		 5kvaA-4tnsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		3 / 3 THR A 162
SER A  58
ASP A 102
 None
 0.81A 5kvaB-4tnsA:
undetectable		 5kvaB-4tnsA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens) 		5 / 12 ASN A  90
ILE A  93
VAL A  62
HIS A  64
PHE A 151
 None
 1.45A 6j21A-4tnsA:
undetectable		 6j21A-4tnsA:
13.72