SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tnu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 8 THR A  53
ASP A 114
HIS A 116
HIS A  21
 None
None
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.2A)
 1.03A 1ei6D-4tnuA:
undetectable		 1ei6D-4tnuA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_A_FCNA1199_1
(EPOXIDASE)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		5 / 9 TYR A 288
ASN A  70
HIS A  21
GLU A  24
HIS A 116
 AS9  A 402 (-4.5A)
AS9  A 402 (-4.0A)
ZN  A 401 ( 3.2A)
ZN  A 401 ( 2.1A)
ZN  A 401 ( 3.4A)
 1.36A 2bnnA-4tnuA:
0.0
2bnnB-4tnuA:
undetectable		 2bnnA-4tnuA:
23.73
2bnnB-4tnuA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 7 ALA A 296
TYR A 155
ILE A 226
HIS A 159
 None
 1.18A 2zm7A-4tnuA:
undetectable		 2zm7A-4tnuA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 4 LEU A  69
ALA A  57
VAL A  58
PRO A  55
 None
 1.14A 3gv1B-4tnuA:
undetectable		 3gv1B-4tnuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 6 CYH A  61
THR A  62
ASN A  23
GLY A 185
 None
 1.26A 3w9tE-4tnuA:
undetectable		 3w9tE-4tnuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 8 ARG A  71
ARG A 168
TYR A 155
GLU A 129
 AS9  A 402 (-3.8A)
AS9  A 402 (-3.1A)
None
None
 1.23A 3zmdA-4tnuA:
undetectable
3zmdB-4tnuA:
undetectable		 3zmdA-4tnuA:
21.02
3zmdB-4tnuA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		4 / 4 ASP A 251
GLY A 180
PRO A 181
GLN A 194
 None
 1.08A 4oltA-4tnuA:
undetectable		 4oltA-4tnuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		3 / 3 ARG A 233
ASP A 230
TYR A 289
 None
 0.86A 4yo9B-4tnuA:
undetectable		 4yo9B-4tnuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		5 / 12 PHE A 209
ILE A 206
ALA A 171
SER A 108
ILE A 111
 None
 1.20A 5mlmA-4tnuA:
undetectable		 5mlmA-4tnuA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 4tnu ASPARTOACYLASE
(Homo
sapiens) 		5 / 9 ILE A 111
ALA A  15
ILE A 199
ALA A 202
LEU A 203
 None
 1.04A 5mvmA-4tnuA:
undetectable
5mvmE-4tnuA:
undetectable		 5mvmA-4tnuA:
14.24
5mvmE-4tnuA:
14.24