SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		5 / 12 THR A  90
ALA A 149
LEU A  36
LEU A  55
LEU A 128
 None
 1.37A 1eiiA-4tnwA:
undetectable		 1eiiA-4tnwA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		3 / 3 VAL A 228
ASN A 331
TRP A 335
 None
 0.95A 2y00B-4tnwA:
3.4		 2y00B-4tnwA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		4 / 8 VAL A  32
THR A  90
TYR A 120
VAL A  30
 None
 0.90A 3fhxB-4tnwA:
undetectable		 3fhxB-4tnwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		3 / 3 ARG A 239
PRO A 243
PHE A 294
 None
 0.99A 3thrC-4tnwA:
undetectable		 3thrC-4tnwA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		4 / 7 ALA A  51
LEU A  53
LEU A  35
ILE A  39
 None
 0.79A 4ubsA-4tnwA:
undetectable		 4ubsA-4tnwA:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		4 / 7 ILE A 229
VAL A 233
TRP A 236
PRO A 324
 None
 0.46A 6cduC-4tnwA:
4.0
6cduD-4tnwA:
18.6		 6cduC-4tnwA:
31.77
6cduD-4tnwA:
31.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA
(Caenorhabditis
elegans) 		4 / 8 ILE A 229
VAL A 233
TRP A 236
PRO A 324
 None
 0.63A 6cduG-4tnwA:
18.7
6cduH-4tnwA:
18.4		 6cduG-4tnwA:
31.77
6cduH-4tnwA:
31.77