SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4to8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 6 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
 1.07A 1rs7B-4to8A:
undetectable		 1rs7B-4to8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		3 / 3 MET A  57
ASN A 233
GLN A  22
 None
FLC  A 302 (-4.2A)
None
 1.06A 1xoqB-4to8A:
undetectable		 1xoqB-4to8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 8 ASN A 231
GLU A 135
HIS A 209
ALA A 172
 None
None
ZN  A 301 ( 3.1A)
None
 0.87A 2bnnA-4to8A:
undetectable
2bnnB-4to8A:
undetectable		 2bnnA-4to8A:
19.39
2bnnB-4to8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 8 LEU A  10
GLU A 135
HIS A 209
ALA A 172
 None
None
ZN  A 301 ( 3.1A)
None
 0.79A 2bnnA-4to8A:
undetectable
2bnnB-4to8A:
undetectable		 2bnnA-4to8A:
19.39
2bnnB-4to8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 5 ILE A 223
PRO A 224
PHE A 192
ILE A 214
 None
 1.12A 2hjhA-4to8A:
undetectable		 2hjhA-4to8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 GLY A 274
ILE A  34
VAL A  45
GLY A  21
ILE A 230
 None
 0.65A 2rkgB-4to8A:
undetectable		 2rkgB-4to8A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 7 PRO A  44
SER A  38
ILE A 276
GLY A  21
 None
 0.99A 2y7kA-4to8A:
undetectable		 2y7kA-4to8A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 11 GLY A 274
ILE A  34
VAL A  45
GLY A  21
ILE A 230
 None
 0.83A 3ebzB-4to8A:
undetectable		 3ebzB-4to8A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 6 GLY A 274
THR A 281
GLU A 270
GLU A  36
 None
 0.92A 3fpjA-4to8A:
undetectable		 3fpjA-4to8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 8 ILE A  82
VAL A  67
THR A  31
ILE A  34
 None
 0.73A 3p4wC-4to8A:
undetectable		 3p4wC-4to8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 10 GLY A 274
ILE A  34
VAL A  45
GLY A  21
ILE A 230
 None
 0.75A 3s43B-4to8A:
undetectable		 3s43B-4to8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 6 GLY A  21
ILE A  46
GLN A  22
VAL A 207
 None
 1.09A 4d39B-4to8A:
undetectable		 4d39B-4to8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 6 LYS A  94
ILE A  97
VAL A 104
LEU A  84
 None
 1.09A 4em2A-4to8A:
undetectable		 4em2A-4to8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 11 GLY A 211
ALA A 174
GLN A  22
PHE A 279
ILE A 219
 None
 1.26A 4j4vA-4to8A:
undetectable		 4j4vA-4to8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 11 GLY A 211
ALA A 174
GLN A  22
PHE A 279
ILE A 219
 None
 1.26A 4j4vD-4to8A:
undetectable
4j4vE-4to8A:
undetectable		 4j4vD-4to8A:
22.95
4j4vE-4to8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 VAL A  67
ILE A  34
LEU A  35
VAL A   4
ALA A  81
 None
 1.43A 4m11D-4to8A:
undetectable		 4m11D-4to8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.49A 4njhA-4to8A:
4.7		 4njhA-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.49A 4njhB-4to8A:
3.2		 4njhB-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.50A 4njiA-4to8A:
4.7		 4njiA-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJI_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.49A 4njiB-4to8A:
2.3		 4njiB-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.50A 4njjA-4to8A:
4.8		 4njjA-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 THR A 234
GLU A 235
ASN A 231
LYS A 275
ASP A 218
 FLC  A 302 (-4.0A)
None
None
None
None
 1.48A 4njjB-4to8A:
3.4		 4njjB-4to8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 GLY A 274
ILE A  34
VAL A  45
GLY A  21
ILE A 230
 None
 0.74A 5e5jA-4to8A:
undetectable		 5e5jA-4to8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		3 / 3 THR A 140
ASP A 107
GLU A 135
 None
 0.85A 5fa8A-4to8A:
undetectable		 5fa8A-4to8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		4 / 8 ILE A  82
VAL A  67
THR A  31
ILE A  34
 None
 0.64A 5mzrE-4to8A:
undetectable		 5mzrE-4to8A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II
(Staphylococcus
aureus) 		5 / 12 GLY A 274
ILE A  34
VAL A  45
GLY A  21
ILE A 230
 None
 0.80A 5t8hA-4to8A:
undetectable		 5t8hA-4to8A:
16.90