SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4toc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.92A 1p7lD-4tocA:
undetectable		 1p7lD-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.91A 1rg9B-4tocA:
undetectable		 1rg9B-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.91A 1rg9A-4tocA:
undetectable		 1rg9A-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.91A 1rg9D-4tocA:
undetectable		 1rg9D-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.92A 1rg9C-4tocA:
undetectable		 1rg9C-4tocA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		6 / 11 GLU A  51
HIS A  54
LEU A  93
GLU A  94
ILE A 123
GLU A 127
 FE2  A 203 ( 2.2A)
FE2  A 203 (-3.6A)
None
FE2  A 205 (-2.5A)
None
FE2  A 203 ( 2.5A)
 0.91A 1rnrA-4tocA:
8.5		 1rnrA-4tocA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		6 / 12 GLU A  51
HIS A  54
LEU A  93
GLU A  94
ILE A 123
GLU A 127
 FE2  A 203 ( 2.2A)
FE2  A 203 (-3.6A)
None
FE2  A 205 (-2.5A)
None
FE2  A 203 ( 2.5A)
 0.95A 1rnrB-4tocA:
8.4		 1rnrB-4tocA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 109
ALA A 104
LEU A 101
VAL A   7
LEU A  11
 None
 1.13A 1sn5B-4tocA:
undetectable
1sn5D-4tocA:
undetectable		 1sn5B-4tocA:
19.75
1sn5D-4tocA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 7 PHE A  26
GLU A  47
ARG A  30
ILE A  49
 HEM  A 207 ( 3.6A)
None
None
HEM  A 207 (-4.7A)
 1.49A 2nsiC-4tocA:
undetectable
2nsiD-4tocA:
undetectable		 2nsiC-4tocA:
17.35
2nsiD-4tocA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  97
GLU A  51
GLU A  18
ALA A  21
 None
FE2  A 203 ( 2.2A)
FE2  A 203 (-2.1A)
None
 1.16A 3r9tC-4tocA:
undetectable		 3r9tC-4tocA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 130
LEU A  58
LEU A  19
ASP A  56
 FE2  A 205 (-4.0A)
None
None
HEM  A 207 ( 4.7A)
 1.29A 4aqlA-4tocA:
undetectable		 4aqlA-4tocA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.91A 4ndnB-4tocA:
undetectable		 4ndnB-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ASP A  90
 None
FE2  A 203 ( 2.5A)
None
None
 0.92A 4ndnD-4tocA:
undetectable		 4ndnD-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.82A 4ndnD-4tocA:
undetectable		 4ndnD-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 8 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.89A 5t8sA-4tocA:
undetectable		 5t8sA-4tocA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  97
GLU A 127
ASP A 132
ASP A  90
 None
FE2  A 203 ( 2.5A)
None
None
 0.95A 6fbnA-4tocA:
undetectable		 6fbnA-4tocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4toc BACTERIOFERRITIN
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  97
GLU A 127
ASP A 132
ILE A 131
 None
FE2  A 203 ( 2.5A)
None
None
 0.86A 6fbnA-4tocA:
undetectable		 6fbnA-4tocA:
16.67