SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4toi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_0 (HEMK PROTEIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	ILE A 200 ILE A 41 VAL A 4 SER A 5 ASN A 203	None	1.04A	1sg9A-4toiA: undetectable	1sg9A-4toiA: 22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QBL_A_CAMA517_0 (CYTOCHROME P450-CAM)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	4 / 7	PHE A 69 LEU A 57 VAL A 221 THR A 220	None	0.93A	2qblA-4toiA: undetectable	2qblA-4toiA: 20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VE3_A_REAA1445_1 (PUTATIVE CYTOCHROME P450 120)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	ALA A 216 LEU A 54 THR A 46 VAL A 14 GLY A 13	None	1.01A	2ve3A-4toiA: undetectable	2ve3A-4toiA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UT5_D_LOCD502_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	ALA A 185 ALA A 176 LYS A 174 ALA A 172 ILE A 181	None	1.04A	3ut5D-4toiA: 3.0	3ut5D-4toiA: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_B_TA1B501_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0B-4toiA: undetectable	6ew0B-4toiA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_D_TA1D501_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0D-4toiA: undetectable	6ew0D-4toiA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_F_TA1F502_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0F-4toiA: undetectable	6ew0F-4toiA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_G_TA1G501_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0G-4toiA: undetectable	6ew0G-4toiA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_H_TA1H501_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0H-4toiA: undetectable	6ew0H-4toiA: 14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EW0_I_TA1I501_1 (TUBULIN BETA CHAIN)	4toi	30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1 (Escherichia coli)	5 / 12	VAL A 196 ASP A 197 LEU A 214 GLN A 89 LEU A 57	None	1.06A	6ew0I-4toiA: undetectable	6ew0I-4toiA: 14.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1SG9_A_SAMA301_0","HEMK PROTEIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"ILE A 200;ILE A  41;VAL A   4;SER A   5;ASN A 203","None","1.04A","1sg9A-4toiA:undetectable","1sg9A-4toiA:22.42"],["2QBL_A_CAMA517_0","CYTOCHROME P450-CAM","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",4,"PHE A  69;LEU A  57;VAL A 221;THR A 220","None","0.93A","2qblA-4toiA:undetectable","2qblA-4toiA:20.97"],["2VE3_A_REAA1445_1","PUTATIVE CYTOCHROME P450 120","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"ALA A 216;LEU A  54;THR A  46;VAL A  14;GLY A  13","None","1.01A","2ve3A-4toiA:undetectable","2ve3A-4toiA:21.34"],["3UT5_D_LOCD502_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"ALA A 185;ALA A 176;LYS A 174;ALA A 172;ILE A 181","None","1.04A","3ut5D-4toiA:3.0","3ut5D-4toiA:22.52"],["6EW0_B_TA1B501_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0B-4toiA:undetectable","6ew0B-4toiA:14.70"],["6EW0_D_TA1D501_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0D-4toiA:undetectable","6ew0D-4toiA:14.70"],["6EW0_F_TA1F502_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0F-4toiA:undetectable","6ew0F-4toiA:14.70"],["6EW0_G_TA1G501_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0G-4toiA:undetectable","6ew0G-4toiA:14.70"],["6EW0_H_TA1H501_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0H-4toiA:undetectable","6ew0H-4toiA:14.70"],["6EW0_I_TA1I501_1","TUBULIN BETA CHAIN","4toi","30S RIBOSOMAL PROTEIN S2,RIBOSOMAL PROTEIN S1","Escherichia coli",5,"VAL A 196;ASP A 197;LEU A 214;GLN A  89;LEU A  57","None","1.06A","6ew0I-4toiA:undetectable","6ew0I-4toiA:14.70"]]