SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4toq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 9 TYR A   6
PHE A  32
GLY A  80
ASP A 125
TYR A 183
 None
 0.73A 1e9lA-4toqA:
19.0		 1e9lA-4toqA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 11 LEU A 100
LEU A 166
LEU A 137
VAL A  33
ILE A 126
 None
 1.20A 1ee2A-4toqA:
undetectable		 1ee2A-4toqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 11 LEU A 100
LEU A 166
LEU A 137
VAL A  33
ILE A 126
 None
 1.21A 1ee2B-4toqA:
undetectable		 1ee2B-4toqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 TYR A  99
ALA A 149
VAL A 118
ALA A 117
MET A  76
 None
 1.14A 1udtA-4toqA:
undetectable		 1udtA-4toqA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 9 TYR A   6
PHE A  32
GLY A  79
ASP A 125
GLN A 181
 None
 1.10A 2uy4A-4toqA:
35.7		 2uy4A-4toqA:
34.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		7 / 9 TYR A   6
PHE A  32
GLY A  80
ASP A 125
GLU A 127
GLN A 181
TYR A 183
 None
 0.26A 2uy4A-4toqA:
35.7		 2uy4A-4toqA:
34.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 10 ALA A 156
ASP A 123
LEU A  75
ILE A  29
TYR A 183
 None
 1.11A 2w9sD-4toqA:
undetectable		 2w9sD-4toqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 10 ALA A 156
ASP A 123
LEU A  75
ILE A  29
TYR A 183
 None
 1.12A 2w9sF-4toqA:
undetectable		 2w9sF-4toqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 THR A  19
VAL A  28
SER A  31
ASN A  10
GLY A  14
 None
 1.04A 2x2iA-4toqA:
9.2		 2x2iA-4toqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 10 THR A  19
VAL A  28
SER A  31
ASN A  10
GLY A  14
 None
 1.10A 2x2iB-4toqA:
undetectable		 2x2iB-4toqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 THR A  19
VAL A  28
SER A  31
ASN A  10
GLY A  14
 None
 1.13A 2x2iC-4toqA:
5.6		 2x2iC-4toqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 10 THR A  19
VAL A  28
SER A  31
ASN A  10
GLY A  14
 None
 1.11A 2x2iD-4toqA:
4.7		 2x2iD-4toqA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 11 TYR A   6
PHE A  32
GLY A  80
ASP A 125
ALA A 226
 None
 0.90A 2xtkA-4toqA:
35.1		 2xtkA-4toqA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		9 / 11 TYR A   6
PHE A  32
GLY A  80
ASP A 125
GLU A 127
GLN A 181
TYR A 183
ASN A 184
ALA A 227
 None
 0.55A 2xtkA-4toqA:
35.1		 2xtkA-4toqA:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		7 / 10 TYR A   6
PHE A  32
GLY A  80
ASP A 125
GLU A 127
GLN A 181
TYR A 183
 None
 0.25A 2xtkB-4toqA:
35.5		 2xtkB-4toqA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 ALA A 156
ILE A 180
ILE A  78
SER A  77
ASP A 163
 None
 1.14A 3axtA-4toqA:
undetectable		 3axtA-4toqA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 9 ALA A 169
LEU A 153
ILE A  78
LEU A 100
THR A 172
 None
 1.36A 3fl9H-4toqA:
undetectable		 3fl9H-4toqA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		4 / 8 ASP A 123
ASP A 125
ASP A 262
TYR A 183
 None
 1.00A 3havA-4toqA:
undetectable		 3havA-4toqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 ASP A 167
ILE A  29
ILE A 126
ALA A 169
TYR A 134
 MG  A 303 ( 4.3A)
None
None
None
None
 1.24A 3ohtA-4toqA:
undetectable
3ohtB-4toqA:
undetectable		 3ohtA-4toqA:
21.81
3ohtB-4toqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQV_A_GCSA501_1
(CHITINASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 11 PHE A  32
GLY A  80
ASP A 125
GLU A 127
TYR A 183
 None
 0.42A 3wqvA-4toqA:
19.4		 3wqvA-4toqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA501_1
(CHITINASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 11 PHE A  32
GLY A  80
ASP A 125
GLU A 127
TYR A 183
 None
 0.43A 3wqwA-4toqA:
19.4		 3wqwA-4toqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 TRP A 207
GLN A 244
THR A 208
 None
None
MG  A 305 (-3.1A)
 0.87A 4m2xA-4toqA:
undetectable		 4m2xA-4toqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 SER A 145
ASP A 120
ASP A  71
 None
 0.91A 4mwzA-4toqA:
undetectable		 4mwzA-4toqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 GLY A   8
GLN A   9
MET A  76
VAL A  33
ILE A  64
 None
 1.25A 4oktA-4toqA:
undetectable		 4oktA-4toqA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 ILE A  64
ASP A 120
ARG A 112
 None
 0.76A 4pstA-4toqA:
undetectable		 4pstA-4toqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 MET A 255
ASP A 125
PHE A 124
 None
 0.88A 4xeyA-4toqA:
undetectable		 4xeyA-4toqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 MET A 255
ASP A 125
PHE A 124
 None
 0.84A 4xeyB-4toqA:
undetectable		 4xeyB-4toqA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		5 / 12 LEU A 170
PHE A 175
VAL A 178
PRO A 157
GLY A  81
 None
 1.22A 5f9zB-4toqA:
undetectable		 5f9zB-4toqA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		4 / 8 PHE A  32
GLY A  80
GLU A 127
TYR A 183
 None
 0.47A 5gqbA-4toqA:
10.2		 5gqbA-4toqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 ASN A 103
SER A 111
SER A 110
 None
 0.69A 5gsnA-4toqA:
undetectable		 5gsnA-4toqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		4 / 8 ALA A 156
ASP A 123
LEU A  75
TYR A 183
 None
 0.84A 5uihA-4toqA:
undetectable		 5uihA-4toqA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 4toq CLASS III CHITINASE
(Punica
granatum) 		3 / 3 THR A  19
THR A  22
ARG A  24
 None
 1.08A 5wm2A-4toqA:
undetectable		 5wm2A-4toqA:
19.04