SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 4 THR A 235
LEU A 239
VAL A 242
LEU A 246
None
None
HEM  A 501 ( 4.1A)
HEM  A 501 ( 4.8A)
0.51A 1fbmB-4tpnA:
undetectable
1fbmB-4tpnA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.48A 1fk9A-4tpnA:
undetectable
1fk9A-4tpnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 11 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.46A 1jkhA-4tpnA:
undetectable
1jkhB-4tpnA:
undetectable
1jkhA-4tpnA:
20.91
1jkhB-4tpnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.40A 1lw0A-4tpnA:
undetectable
1lw0A-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 11 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.43A 1lwcA-4tpnA:
undetectable
1lwcA-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 4 THR A 235
LEU A 239
VAL A 242
LEU A 246
None
None
HEM  A 501 ( 4.1A)
HEM  A 501 ( 4.8A)
0.67A 1mz9D-4tpnA:
undetectable
1mz9D-4tpnA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 LEU A 220
VAL A 216
PHE A 106
VAL A 102
THR A 235
None
1.35A 1q23B-4tpnA:
undetectable
1q23B-4tpnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 9 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.50A 1vrtA-4tpnA:
undetectable
1vrtA-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 287
SER A 254
THR A 251
ALA A 360
ALA A 359
None
HEM  A 501 (-3.6A)
HEM  A 501 (-4.0A)
GOL  A 503 (-3.9A)
HEM  A 501 (-3.4A)
1.42A 1wygA-4tpnA:
0.6
1wygA-4tpnA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 5 GLY A 206
PRO A 158
VAL A 157
ILE A 217
None
0.96A 2aoiA-4tpnA:
undetectable
2aoiA-4tpnA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 7 ARG A 326
GLU A 285
ASN A 265
ALA A 261
None
1.12A 2ejgB-4tpnA:
undetectable
2ejgB-4tpnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.44A 2hndA-4tpnA:
undetectable
2hndA-4tpnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.44A 2hnyA-4tpnA:
undetectable
2hnyA-4tpnA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
3 / 3 ASP A  22
ARG A  27
ARG A  26
None
1.09A 2j9dA-4tpnA:
undetectable
2j9dC-4tpnA:
undetectable
2j9dA-4tpnA:
13.78
2j9dC-4tpnA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 7 ARG A 326
GLU A 285
ASN A 265
ALA A 261
None
1.03A 2zgwA-4tpnA:
undetectable
2zgwA-4tpnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
3 / 3 ALA A 245
THR A 250
CYH A 357
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.4A)
0.79A 3e4eA-4tpnA:
28.4
3e4eA-4tpnA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
3 / 3 ALA A 245
THR A 250
CYH A 357
HEM  A 501 (-3.4A)
HEM  A 501 (-3.9A)
HEM  A 501 (-2.4A)
0.70A 3e4eB-4tpnA:
28.5
3e4eB-4tpnA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 ALA A 144
GLU A 135
SER A 128
PRO A 130
LEU A 405
None
1.22A 3eigA-4tpnA:
undetectable
3eigA-4tpnA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 TYR A 114
LEU A 220
PHE A 155
VAL A 242
ALA A 359
None
None
HEM  A 501 ( 4.9A)
HEM  A 501 ( 4.1A)
HEM  A 501 (-3.4A)
1.45A 3nuvA-4tpnA:
undetectable
3nuvA-4tpnA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 5 LEU A 260
ARG A 396
LEU A 401
PRO A 387
None
1.25A 3onnA-4tpnA:
undetectable
3onnA-4tpnA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.44A 3qipA-4tpnA:
undetectable
3qipA-4tpnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 7 GLY A 385
ALA A 384
ALA A 263
ARG A 382
None
0.88A 3ur0B-4tpnA:
undetectable
3ur0B-4tpnA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 PHE A 262
ALA A 263
PHE A 337
LEU A 339
GLY A 253
None
1.14A 4kykA-4tpnA:
undetectable
4kykB-4tpnA:
undetectable
4kykA-4tpnA:
18.89
4kykB-4tpnA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 LEU A 348
GLY A 351
GLN A 352
HIS A  95
VAL A  87
None
HEM  A 501 (-4.2A)
None
HEM  A 501 (-3.8A)
HEM  A 501 (-3.8A)
1.38A 4okxA-4tpnA:
undetectable
4okxA-4tpnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 7 ILE A 129
LEU A 125
ALA A 141
ILE A 136
None
0.82A 4y03A-4tpnA:
undetectable
4y03A-4tpnA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 GLY A 226
LEU A 239
TYR A 199
GLY A 156
THR A 215
None
1.28A 5fsaB-4tpnA:
26.6
5fsaB-4tpnA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 11 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.44A 5hbmA-4tpnA:
undetectable
5hbmA-4tpnA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 11 ALA A 104
GLY A 105
ALA A 110
THR A 107
LEU A 118
None
None
SO4  A 510 ( 4.8A)
SO4  A 510 ( 2.8A)
None
0.99A 5lf7H-4tpnA:
undetectable
5lf7I-4tpnA:
undetectable
5lf7H-4tpnA:
23.15
5lf7I-4tpnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 11 ALA A 104
GLY A 105
ALA A 110
THR A 107
LEU A 118
None
None
SO4  A 510 ( 4.8A)
SO4  A 510 ( 2.8A)
None
0.99A 5lf7V-4tpnA:
undetectable
5lf7W-4tpnA:
undetectable
5lf7V-4tpnA:
23.15
5lf7W-4tpnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 LEU A 374
LEU A 142
LEU A 125
HIS A 123
VAL A 126
None
0.79A 5twjA-4tpnA:
undetectable
5twjA-4tpnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 374
LEU A 142
LEU A 125
HIS A 123
VAL A 126
None
0.78A 5twjB-4tpnA:
undetectable
5twjB-4tpnA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 5 ASP A  22
ASP A  15
ASN A 335
ARG A 333
None
1.45A 5vooB-4tpnA:
undetectable
5vooB-4tpnA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
4 / 5 ASP A  22
ASP A  15
ASN A 335
ARG A 333
None
1.46A 5vooD-4tpnA:
undetectable
5vooD-4tpnA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.48A 6bsgA-4tpnA:
undetectable
6bsgA-4tpnA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 10 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
None
1.48A 6bsjA-4tpnA:
undetectable
6bsjA-4tpnA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
5 / 12 ASN A 390
PHE A 395
LEU A 393
PHE A 295
ILE A 244
SO4  A 506 ( 3.8A)
SO4  A 511 (-4.7A)
None
None
None
1.31A 6dwnA-4tpnA:
26.4
6dwnA-4tpnA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei)
3 / 3 PHE A 331
ARG A 346
ALA A  44
None
0.88A 6ecfB-4tpnA:
undetectable
6ecfB-4tpnA:
25.12