SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 THR B  31
THR B  44
PRO B  46
 None
 0.84A 1a7yA-4tpsB:
undetectable		 1a7yA-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 THR B  31
THR B  44
PRO B  46
 None
 0.84A 1a7yB-4tpsB:
undetectable		 1a7yB-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		5 / 12 ILE B   4
ALA B  33
ASN B   9
THR B  65
LEU B  69
 None
 1.09A 1og5B-4tpsB:
undetectable		 1og5B-4tpsB:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 THR B  31
THR B  44
PRO B  46
 None
 0.85A 1qfiA-4tpsB:
undetectable		 1qfiA-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 THR B  31
THR B  44
PRO B  46
 None
 0.82A 1qfiB-4tpsB:
undetectable		 1qfiB-4tpsB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
(Bacillus
subtilis) 		4 / 8 LEU A   9
ILE A  58
ILE A  56
THR A   7
 None
 0.98A 1sbrA-4tpsA:
2.5		 1sbrA-4tpsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		4 / 5 LEU B  41
LEU B  59
MET B  28
THR B  70
 None
 0.87A 2oaxD-4tpsB:
undetectable		 2oaxD-4tpsB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis;
Bacillus
subtilis) 		3 / 3 PHE A  14
SER B  56
LEU B  54
 None
 0.79A 2w1bA-4tpsA:
undetectable		 2w1bA-4tpsA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 ARG A  21
ARG B  51
GLU B  55
SER B  56
 None
 1.15A 2zt7A-4tpsA:
undetectable		 2zt7A-4tpsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
(Bacillus
subtilis) 		3 / 3 MET A  96
MET A 129
PHE A 115
 None
 1.24A 3gn8A-4tpsA:
undetectable		 3gn8A-4tpsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		5 / 12 THR B  31
THR B  44
HIS B  34
LEU B  41
ILE B  62
 None
 1.36A 3gwxB-4tpsB:
undetectable		 3gwxB-4tpsB:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 GLU B   2
LEU B   5
ASP B   6
 None
 0.37A 3ko0A-4tpsB:
undetectable		 3ko0A-4tpsB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis) 		3 / 3 GLU B   2
LEU B   5
ASP B   6
 None
 0.34A 3ko0T-4tpsB:
undetectable		 3ko0T-4tpsB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
(Bacillus
subtilis) 		4 / 7 ILE A  80
LEU A  65
THR A   7
THR A  72
 None
 1.02A 3nxuA-4tpsA:
undetectable		 3nxuA-4tpsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
(Bacillus
subtilis) 		4 / 6 LEU A  28
ILE A  56
ARG A 120
ILE A 101
 None
 0.71A 4tyjA-4tpsA:
undetectable		 4tyjA-4tpsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA
(Bacillus
subtilis;
Bacillus
subtilis) 		4 / 7 TYR B  58
TYR A  51
SER B  20
LEU B  19
 None
 1.15A 5bphB-4tpsB:
undetectable		 5bphB-4tpsB:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA
(Bacillus
subtilis) 		4 / 7 ILE A  80
LEU A  65
THR A   7
THR A  72
 None
 1.03A 5vc0A-4tpsA:
undetectable		 5vc0A-4tpsA:
15.86