SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A 552
VAL A 535
TRP A 512
 None
 1.25A 1qw6A-4tptA:
undetectable		 1qw6A-4tptA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A 552
VAL A 535
TRP A 512
 None
 1.23A 1qwcA-4tptA:
undetectable		 1qwcA-4tptA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 ARG A 552
VAL A 535
TRP A 512
 None
 1.23A 1vagA-4tptA:
undetectable		 1vagA-4tptA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 417
VAL A 543
VAL A 467
PHE A 532
PHE A 594
 None
 1.45A 2y00A-4tptA:
2.0		 2y00A-4tptA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 GLY A 411
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 None
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.69A 3cs9B-4tptA:
22.6		 3cs9B-4tptA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 3ik3A-4tptA:
22.0		 3ik3A-4tptA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.44A 3ik3B-4tptA:
21.8		 3ik3B-4tptA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		8 / 12 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.10A 3zosA-4tptA:
20.5		 3zosA-4tptA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		8 / 12 THR A 405
LEU A 442
HIS A 449
ARG A 450
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-3.8A)
35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.11A 3zosB-4tptA:
20.4		 3zosB-4tptA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		7 / 12 LEU A 389
THR A 405
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 (-4.6A)
35H  A 701 (-3.8A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 1.02A 4c8bA-4tptA:
21.3		 4c8bA-4tptA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 10 LEU A 536
ILE A 534
ILE A 539
PHE A 532
SER A 531
 None
 1.01A 4fakA-4tptA:
undetectable		 4fakA-4tptA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
ARG A 450
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.83A 4qrcA-4tptA:
21.7		 4qrcA-4tptA:
29.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4tyjA-4tptA:
21.9		 4tyjA-4tptA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 442
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.48A 4uxqA-4tptA:
21.7		 4uxqA-4tptA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4v01A-4tptA:
21.4		 4v01A-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.53A 4v01B-4tptA:
21.6		 4v01B-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.52A 4v04B-4tptA:
21.2		 4v04B-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 ASP A 524
ARG A 591
PRO A 588
 None
 0.99A 4wanC-4tptA:
1.8		 4wanC-4tptA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 PRO A 616
LYS A 433
VAL A 429
PHE A 576
LEU A 579
 None
 1.41A 5cymA-4tptA:
undetectable		 5cymA-4tptA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 PRO A 616
LYS A 433
VAL A 429
PHE A 576
LEU A 579
 None
 1.40A 5cyqA-4tptA:
undetectable		 5cyqA-4tptA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 12 PRO A 616
LYS A 433
VAL A 429
PHE A 576
LEU A 579
 None
 1.41A 6eliA-4tptA:
undetectable		 6eliA-4tptA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 403
LEU A 472
ARG A 364
 35H  A 701 ( 4.2A)
35H  A 701 (-3.7A)
None
 0.58A 6fgcA-4tptA:
undetectable		 6fgcA-4tptA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 403
LEU A 472
ARG A 364
 35H  A 701 ( 4.2A)
35H  A 701 (-3.7A)
None
 0.62A 6fgdA-4tptA:
undetectable		 6fgdA-4tptA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 11 GLY A 533
LEU A 597
ALA A 436
ALA A 432
PHE A 601
 None
 1.09A 6qgbA-4tptA:
undetectable		 6qgbA-4tptA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 4tpt LIM DOMAIN KINASE 2
(Homo
sapiens) 		5 / 11 GLY A 533
LEU A 597
ALA A 436
ALA A 432
PHE A 601
 None
 1.10A 6qgbE-4tptA:
undetectable		 6qgbE-4tptA:
17.63