SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		3 / 3 SER A  62
GLU A  63
GLU A  64
 None
 0.53A 1eqbD-4tpvA:
undetectable		 1eqbD-4tpvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		3 / 3 SER A  62
GLU A  63
GLU A  64
 None
 0.53A 1eqbB-4tpvA:
undetectable		 1eqbB-4tpvA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		4 / 6 HIS A  25
PHE A  21
ASP A  73
PRO A  83
 None
 1.32A 1ilqA-4tpvA:
undetectable
1ilqC-4tpvA:
undetectable		 1ilqA-4tpvA:
15.92
1ilqC-4tpvA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		4 / 8 GLU A  68
SER A 118
ASP A 117
GLU A  69
 None
 1.03A 1knyA-4tpvA:
undetectable
1knyB-4tpvA:
undetectable		 1knyA-4tpvA:
18.67
1knyB-4tpvA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		3 / 3 HIS A 183
ASP A 172
ASN A 175
 None
 0.80A 1wg8B-4tpvA:
undetectable		 1wg8B-4tpvA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		3 / 3 ASP A 117
ARG A 159
LYS A  40
 None
 0.76A 3wipG-4tpvA:
undetectable		 3wipG-4tpvA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		5 / 12 TYR A 139
ILE A 111
ASN A 110
SER A 118
PHE A  32
 None
 1.21A 4obwC-4tpvA:
undetectable		 4obwC-4tpvA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 4tpv PLATELET INHIBITOR
(Ancylostoma
caninum) 		3 / 3 VAL A 127
TYR A  55
ALA A  58
 None
GOL  A 201 ( 3.4A)
None
 0.44A 4ybnA-4tpvA:
undetectable		 4ybnA-4tpvA:
20.44