SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tq5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 164
LEU A 168
ALA A 183
VAL A 237
LEU A  31
 None
 1.11A 1cbsA-4tq5A:
undetectable		 1cbsA-4tq5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  50
LEU A  52
ILE A 121
SER A  46
 None
 0.96A 1sbrA-4tq5A:
undetectable
1sbrB-4tq5A:
undetectable		 1sbrA-4tq5A:
22.74
1sbrB-4tq5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 ALA A 159
TYR A 139
ILE A 135
ASP A 152
 None
 0.77A 1upfA-4tq5A:
undetectable		 1upfA-4tq5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 5 ALA A 159
TYR A 139
ILE A 135
ASP A 152
 None
 0.76A 1upfC-4tq5A:
undetectable		 1upfC-4tq5A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  54
LEU A  30
PHE A 125
MET A 129
 None
 1.04A 1wrlE-4tq5A:
undetectable
1wrlF-4tq5A:
undetectable		 1wrlE-4tq5A:
12.54
1wrlF-4tq5A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 164
LEU A 168
ALA A 183
VAL A 237
LEU A  31
 None
 1.05A 2fr3A-4tq5A:
undetectable		 2fr3A-4tq5A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.39A 3dqtA-4tq5A:
2.9
3dqtB-4tq5A:
1.4		 3dqtA-4tq5A:
21.09
3dqtB-4tq5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.29A 3n5tA-4tq5A:
1.6
3n5tB-4tq5A:
1.4		 3n5tA-4tq5A:
20.47
3n5tB-4tq5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 SER A 250
ILE A 246
LEU A 168
GLY A  40
PHE A  39
 None
 1.35A 4foxE-4tq5A:
undetectable		 4foxE-4tq5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TYR A 137
ILE A  67
TYR A  71
PRO A 142
 None
 1.13A 4g5jA-4tq5A:
undetectable		 4g5jA-4tq5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.37A 4k5jA-4tq5A:
1.5
4k5jB-4tq5A:
undetectable		 4k5jA-4tq5A:
20.51
4k5jB-4tq5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 11 LEU A 186
ALA A 183
LEU A  31
GLY A 167
LEU A 168
 None
 1.26A 5dxgB-4tq5A:
undetectable		 5dxgB-4tq5A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.40A 5fj3A-4tq5A:
1.6
5fj3B-4tq5A:
1.3		 5fj3A-4tq5A:
20.51
5fj3B-4tq5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 292
PHE A 291
PHE A  57
TRP A  60
 None
 1.34A 5g08A-4tq5A:
undetectable		 5g08A-4tq5A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		5 / 12 MET A  61
ALA A 159
LEU A 162
ALA A 163
LEU A  30
 None
 1.08A 5k9dA-4tq5A:
undetectable		 5k9dA-4tq5A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 8 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.35A 5uo7A-4tq5A:
1.6
5uo7B-4tq5A:
1.5		 5uo7A-4tq5A:
19.91
5uo7B-4tq5A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 6 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.41A 5uo8A-4tq5A:
undetectable
5uo8B-4tq5A:
undetectable		 5uo8A-4tq5A:
20.85
5uo8B-4tq5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.38A 5vv7A-4tq5A:
1.5
5vv7B-4tq5A:
1.4		 5vv7A-4tq5A:
20.51
5vv7B-4tq5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.38A 5vvnA-4tq5A:
1.1
5vvnB-4tq5A:
undetectable		 5vvnA-4tq5A:
20.51
5vvnB-4tq5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.45A 6av6A-4tq5A:
undetectable
6av6B-4tq5A:
undetectable		 6av6A-4tq5A:
14.63
6av6B-4tq5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 TRP A  60
PHE A  57
SER A  64
TRP A  26
 None
 1.39A 6av6C-4tq5A:
undetectable
6av6D-4tq5A:
undetectable		 6av6C-4tq5A:
14.63
6av6D-4tq5A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tq5 PRENYLTRANSFERASE
(Archaeoglobus
fulgidus) 		4 / 7 SER A  64
TRP A  26
TRP A  60
PHE A  57
 None
 1.43A 6av7A-4tq5A:
undetectable
6av7B-4tq5A:
undetectable		 6av7A-4tq5A:
14.63
6av7B-4tq5A:
14.63