SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		4 / 8 GLY A  13
SER A  35
TYR A  48
HIS A  41
 NDP  A 400 ( 4.4A)
NDP  A 400 (-3.7A)
None
None
 1.07A 1maaD-4tqgA:
undetectable		 1maaD-4tqgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		4 / 8 SER A 302
SER A 303
ILE A 307
GLY A 169
 None
None
None
NDP  A 400 (-4.8A)
 0.68A 1me7A-4tqgA:
undetectable		 1me7A-4tqgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		4 / 5 LEU A  17
VAL A 111
LEU A 119
ARG A  72
 NDP  A 400 (-4.0A)
None
None
None
 1.12A 2oiqA-4tqgA:
undetectable		 2oiqA-4tqgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		3 / 3 TYR A 316
ASP A 210
ASP A 281
 None
 0.88A 4a6eA-4tqgA:
5.0		 4a6eA-4tqgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		5 / 11 VAL A 166
VAL A 128
ILE A   8
ILE A  10
TYR A  25
 None
NDP  A 400 (-4.6A)
None
None
None
 1.05A 5e4dB-4tqgA:
undetectable		 5e4dB-4tqgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		5 / 11 VAL A 166
VAL A 164
ILE A   3
ILE A  77
TYR A  25
 None
 0.98A 5e4dB-4tqgA:
undetectable		 5e4dB-4tqgA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		3 / 3 GLY A 256
LEU A 257
HIS A 198
 None
 0.49A 5u63A-4tqgA:
3.4		 5u63A-4tqgA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 4tqg PUTATIVE
DTDP-D-GLUCOSE 4
6-DEHYDRATASE
(Megavirus
chiliensis) 		3 / 3 GLY A 256
LEU A 257
HIS A 198
 None
 0.52A 5u63B-4tqgA:
undetectable		 5u63B-4tqgA:
20.87