SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ALA A 352
ASP A 290
VAL A 300
GLY A 371
PHE A 328
 None
 1.18A 1d4sA-4tqkA:
undetectable		 1d4sA-4tqkA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 8 MET A 399
PHE A 357
THR A 380
LEU A  39
 None
 1.12A 1ea1A-4tqkA:
undetectable		 1ea1A-4tqkA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 235
GLY A 240
ASP A 179
VAL A 233
GLY A 261
 None
 0.96A 1k6cB-4tqkA:
undetectable		 1k6cB-4tqkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.76A 1k6cB-4tqkA:
undetectable		 1k6cB-4tqkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.88A 1muiA-4tqkA:
undetectable		 1muiA-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.83A 1rl8A-4tqkA:
undetectable		 1rl8A-4tqkA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.85A 1sdtB-4tqkA:
undetectable		 1sdtB-4tqkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 1sdvB-4tqkA:
undetectable		 1sdvB-4tqkA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 5 LYS A 377
PHE A 342
LEU A 379
LEU A 291
 None
 1.45A 1skxA-4tqkA:
undetectable		 1skxA-4tqkA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.80A 1t7jA-4tqkA:
undetectable		 1t7jA-4tqkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASN A 145
THR A  67
LEU A 121
VAL A 142
PHE A  78
 None
 1.41A 1tw4A-4tqkA:
undetectable		 1tw4A-4tqkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 5 ALA A  36
ASN A  35
ILE A  22
ASP A  21
 None
 1.12A 1yc2D-4tqkA:
undetectable		 1yc2D-4tqkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.80A 2avoB-4tqkA:
undetectable		 2avoB-4tqkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.74A 2bpxB-4tqkA:
undetectable		 2bpxB-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.83A 2f80A-4tqkA:
undetectable		 2f80A-4tqkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 5 ALA A  36
ASN A  35
ILE A  22
ASP A  21
 None
 1.06A 2h4jA-4tqkA:
undetectable		 2h4jA-4tqkA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.84A 2ieoA-4tqkA:
undetectable		 2ieoA-4tqkA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 235
GLY A 240
ASP A 179
VAL A 233
GLY A 261
 None
 0.92A 2o4sA-4tqkA:
undetectable		 2o4sA-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 353
ALA A 352
CYH A 351
SER A  16
GLY A 348
 None
 1.10A 2p16A-4tqkA:
undetectable		 2p16A-4tqkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.92A 2q5kB-4tqkA:
undetectable		 2q5kB-4tqkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.89A 2r5pB-4tqkA:
undetectable		 2r5pB-4tqkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.84A 2z54B-4tqkA:
undetectable		 2z54B-4tqkA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 HIS A 173
ARG A 169
ARG A 172
VAL A 196
GLY A 261
 NAG  A 503 (-3.9A)
None
None
None
None
 1.45A 3bf6H-4tqkA:
undetectable		 3bf6H-4tqkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.81A 3cywB-4tqkA:
undetectable		 3cywB-4tqkA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 4 ILE A 188
GLN A   8
ILE A 124
LEU A 170
 None
 1.20A 3dzyD-4tqkA:
undetectable		 3dzyD-4tqkA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ILE A 244
GLN A 265
ASN A 258
VAL A 189
ILE A 198
 None
 0.92A 3e00A-4tqkA:
undetectable		 3e00A-4tqkA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 9 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.87A 3ektA-4tqkA:
undetectable		 3ektA-4tqkA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 3ektC-4tqkA:
undetectable		 3ektC-4tqkA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.80A 3ekvA-4tqkA:
undetectable		 3ekvA-4tqkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.85A 3ekxA-4tqkA:
undetectable		 3ekxA-4tqkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.88A 3el5B-4tqkA:
undetectable		 3el5B-4tqkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		6 / 12 GLY A 238
GLY A 240
VAL A 189
PHE A 191
ASP A 243
ILE A 244
 None
 1.24A 3elwA-4tqkA:
undetectable		 3elwA-4tqkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.82A 3jvyB-4tqkA:
undetectable		 3jvyB-4tqkA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 7 PHE A 217
PHE A 191
PHE A 232
PHE A 176
 None
 1.16A 3ko0D-4tqkA:
undetectable
3ko0E-4tqkA:
undetectable		 3ko0D-4tqkA:
11.79
3ko0E-4tqkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 7 PHE A 273
GLY A 251
PHE A 287
PHE A 232
 None
 0.92A 3ko0D-4tqkA:
undetectable
3ko0E-4tqkA:
undetectable		 3ko0D-4tqkA:
11.79
3ko0E-4tqkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 5 PHE A 217
PHE A 191
PHE A 232
PHE A 176
 None
 1.26A 3ko0F-4tqkA:
undetectable
3ko0G-4tqkA:
undetectable		 3ko0F-4tqkA:
11.79
3ko0G-4tqkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.81A 3mwsA-4tqkA:
undetectable		 3mwsA-4tqkA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.83A 3ndtD-4tqkA:
undetectable		 3ndtD-4tqkA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASN A  88
PHE A  42
PHE A  25
VAL A  23
ASN A  92
 None
 1.31A 3nuvA-4tqkA:
undetectable		 3nuvA-4tqkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.81A 3oxwA-4tqkA:
undetectable		 3oxwA-4tqkA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 3oxxA-4tqkA:
undetectable		 3oxxA-4tqkA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 9 ASP A 179
ASP A 187
ILE A 198
GLY A 260
ILE A 214
 None
 0.92A 3s53A-4tqkA:
undetectable		 3s53A-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 9 ASP A 290
GLY A 295
ASP A 235
ILE A 288
GLY A 316
 None
 0.84A 3s53A-4tqkA:
undetectable		 3s53A-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 4dqbB-4tqkA:
undetectable		 4dqbB-4tqkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 9 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.81A 4dqcB-4tqkA:
undetectable		 4dqcB-4tqkA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.85A 4dqeB-4tqkA:
undetectable		 4dqeB-4tqkA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 4dqhB-4tqkA:
undetectable		 4dqhB-4tqkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.84A 4ll3B-4tqkA:
undetectable		 4ll3B-4tqkA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.81A 4ll3A-4tqkA:
undetectable		 4ll3A-4tqkA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.86A 4njtB-4tqkA:
undetectable		 4njtB-4tqkA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.87A 4njvB-4tqkA:
undetectable		 4njvB-4tqkA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.91A 4njvC-4tqkA:
undetectable		 4njvC-4tqkA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 10 ASP A 290
GLY A 295
ASP A 235
ILE A 288
GLY A 316
 None
 0.93A 4q1yA-4tqkA:
undetectable		 4q1yA-4tqkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 290
GLY A 295
ASP A 235
ILE A 288
GLY A 316
 None
 0.83A 5e5kB-4tqkA:
undetectable		 5e5kB-4tqkA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 11 TYR A 120
ILE A 188
PHE A 191
LEU A 174
PHE A 135
 None
 1.17A 5huaA-4tqkA:
undetectable		 5huaA-4tqkA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 5 VAL A  85
THR A  67
ASN A 145
LEU A 149
 None
 1.32A 5m0iB-4tqkA:
undetectable		 5m0iB-4tqkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 6 THR A 127
ARG A 129
ASP A  66
GLY A  71
 None
 1.08A 5mraA-4tqkA:
undetectable
5mraB-4tqkA:
undetectable		 5mraA-4tqkA:
18.72
5mraB-4tqkA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 GLY A  53
GLY A  29
TRP A  55
VAL A  23
ILE A  75
 NAG  A 502 (-4.2A)
None
NAG  A 502 (-3.6A)
None
None
 1.00A 5njvD-4tqkA:
undetectable		 5njvD-4tqkA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		4 / 7 TRP A 279
ASP A 272
LYS A 277
SER A 320
 NAG  A 505 (-3.5A)
NAG  A 505 (-2.8A)
NAG  A 505 (-4.4A)
None
 1.48A 5nr3A-4tqkA:
undetectable		 5nr3A-4tqkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.78A 6dj1A-4tqkA:
undetectable		 6dj1A-4tqkA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.93A 6dj1B-4tqkA:
undetectable		 6dj1B-4tqkA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		5 / 12 ASP A 345
GLY A 350
ASP A 290
VAL A 343
GLY A 371
 None
 0.92A 6dj2B-4tqkA:
undetectable		 6dj2B-4tqkA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		3 / 3 ARG A 113
HIS A 117
ARG A 119
 None
NAG  A 501 (-3.7A)
None
 1.19A 6dwdD-4tqkA:
undetectable		 6dwdD-4tqkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tqk LECTIN 2
(Agrocybe
aegerita) 		3 / 3 ARG A 169
HIS A 173
ARG A 175
 None
NAG  A 503 (-3.9A)
None
 1.09A 6dwdD-4tqkA:
undetectable		 6dwdD-4tqkA:
22.36