SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 PHE B 583
LEU B 577
ALA B 579
ALA B 582
PRO B 467
None
1.26A 1cbrA-4tqoB:
undetectable
1cbrA-4tqoB:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 PHE B 583
LEU B 577
ALA B 579
ALA B 582
PRO B 467
None
1.26A 1cbrB-4tqoB:
undetectable
1cbrB-4tqoB:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 8 ASN B  41
LEU B  35
ASP B  38
GLU B  31
None
1.00A 1mxgA-4tqoB:
undetectable
1mxgA-4tqoB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 VAL B 193
LEU B 236
ALA B 214
LEU B 198
None
0.73A 1pthA-4tqoB:
undetectable
1pthA-4tqoB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 VAL B 193
LEU B 236
ALA B 214
LEU B 198
None
0.73A 1pthB-4tqoB:
undetectable
1pthB-4tqoB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 4 LEU B 361
VAL B 362
ILE B 378
TRP B 384
None
1.45A 1s9qB-4tqoB:
undetectable
1s9qB-4tqoB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 8 VAL B 496
GLY B 437
THR B 500
VAL B 508
None
0.78A 2a1mB-4tqoB:
undetectable
2a1mB-4tqoB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 7 TYR B 211
GLY B 200
THR B 213
TYR B 215
ASN B 270
None
1.36A 2g70A-4tqoB:
undetectable
2g70A-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 7 TYR B 211
GLY B 200
THR B 213
TYR B 215
ASN B 270
None
1.35A 2g70B-4tqoB:
undetectable
2g70B-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 6 TYR B 211
GLY B 200
TYR B 215
ASN B 270
None
1.08A 2g72A-4tqoB:
undetectable
2g72A-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 TYR B 211
GLY B 200
TYR B 215
ASN B 270
None
1.06A 2g72B-4tqoB:
undetectable
2g72B-4tqoB:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 GLU B  83
PRO B 190
MET B  44
GLY B  84
PQQ  B 702 (-2.9A)
None
None
None
1.26A 2hs1B-4tqoB:
undetectable
2hs1B-4tqoB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 ARG B  56
VAL B 508
THR B 522
None
0.84A 2nmzA-4tqoB:
undetectable
2nmzA-4tqoB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 10 THR B 369
GLY B 370
TYR B 322
HIS B 247
PRO B 246
None
1.36A 2y7pA-4tqoB:
undetectable
2y7pA-4tqoB:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 ARG B 137
ASP B 357
ASN B 421
PQQ  B 702 (-3.0A)
None
PQQ  B 702 (-3.7A)
0.80A 2zzmA-4tqoB:
undetectable
2zzmA-4tqoB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 5 ILE B 424
HIS B 540
ARG B 137
GLY B 498
None
None
PQQ  B 702 (-3.0A)
None
1.27A 3b9mA-4tqoB:
undetectable
3b9mA-4tqoB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 GLY B 539
GLY B 423
GLY B 498
None
0.38A 3bogD-4tqoB:
undetectable
3bogD-4tqoB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 440
VAL B 438
THR B 381
VAL B 382
VAL B 362
None
1.18A 3czvA-4tqoB:
undetectable
3czvB-4tqoB:
undetectable
3czvA-4tqoB:
17.13
3czvB-4tqoB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.11A 3eeyA-4tqoB:
undetectable
3eeyA-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.10A 3eeyB-4tqoB:
undetectable
3eeyB-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.09A 3eeyC-4tqoB:
undetectable
3eeyC-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.09A 3eeyD-4tqoB:
undetectable
3eeyD-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.10A 3eeyE-4tqoB:
undetectable
3eeyE-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.11A 3eeyH-4tqoB:
undetectable
3eeyH-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.11A 3eeyI-4tqoB:
undetectable
3eeyI-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 188
ASN B 155
ILE B 424
GLY B 423
ASN B 270
None
1.11A 3eeyJ-4tqoB:
undetectable
3eeyJ-4tqoB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 TYR B 332
GLY B 334
TRP B 384
LEU B 361
PRO B 356
None
1.20A 3mecA-4tqoB:
undetectable
3mecA-4tqoB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 8 ASP B 331
GLY B 334
GLU B 205
ARG B 137
CA  B 701 ( 3.1A)
None
CA  B 701 ( 2.2A)
PQQ  B 702 (-3.0A)
0.93A 3s3mA-4tqoB:
undetectable
3s3mA-4tqoB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 539
GLY B 499
THR B 500
LEU B 501
GLY B  84
None
1.02A 3sglA-4tqoB:
undetectable
3sglA-4tqoB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 ASN B 136
GLY B 560
ALA B 204
GLY B 203
ASN B 289
None
PQQ  B 702 (-3.6A)
PQQ  B 702 (-3.0A)
PQQ  B 702 (-3.1A)
CA  B 701 ( 2.8A)
1.21A 3v3oA-4tqoB:
undetectable
3v3oA-4tqoB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus)
4 / 5 GLU B 171
GLU B 170
PHE I  86
HIS B 147
None
1.46A 4a97J-4tqoB:
undetectable
4a97J-4tqoB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 TYR B  94
MET B  93
ILE B 552
None
0.85A 4c8bB-4tqoB:
undetectable
4c8bB-4tqoB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 ASP B 357
ASN B 336
GLY B 288
ASN B 289
ARG B 298
None
None
None
CA  B 701 ( 2.8A)
None
1.32A 4djeB-4tqoB:
undetectable
4djeB-4tqoB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 6 GLY B 539
VAL B 537
GLY B 437
GLU B 492
None
0.88A 4dxuA-4tqoB:
undetectable
4dxuA-4tqoB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 ALA B 204
GLY B 267
GLY B 286
ASN B 289
TRP B 271
PQQ  B 702 (-3.0A)
None
None
CA  B 701 ( 2.8A)
PQQ  B 702 (-3.5A)
1.22A 4e47A-4tqoB:
undetectable
4e47A-4tqoB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 ALA B 204
GLY B 267
GLY B 286
ASN B 289
TRP B 271
PQQ  B 702 (-3.0A)
None
None
CA  B 701 ( 2.8A)
PQQ  B 702 (-3.5A)
1.25A 4e47B-4tqoB:
undetectable
4e47B-4tqoB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 TYR B 284
LEU B 353
ASN B 366
TYR B 248
None
1.13A 4f8yC-4tqoB:
undetectable
4f8yD-4tqoB:
undetectable
4f8yC-4tqoB:
16.08
4f8yD-4tqoB:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 9 GLY B 563
GLY B 565
GLY B 559
PHE B 568
ASP B 133
None
1.15A 4h2fA-4tqoB:
undetectable
4h2fA-4tqoB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 9 GLY B 563
GLY B 565
GLY B 559
PHE B 568
ASP B 133
None
1.17A 4h2gA-4tqoB:
undetectable
4h2gA-4tqoB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
VAL B 388
SER B 341
GLY B 339
None
1.26A 4hvcB-4tqoB:
undetectable
4hvcB-4tqoB:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 ALA B 204
GLY B 267
GLY B 286
ASN B 289
TRP B 271
PQQ  B 702 (-3.0A)
None
None
CA  B 701 ( 2.8A)
PQQ  B 702 (-3.5A)
1.23A 4jdsA-4tqoB:
undetectable
4jdsA-4tqoB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 ALA B 204
GLY B 267
GLY B 286
ASN B 289
TRP B 271
PQQ  B 702 (-3.0A)
None
None
CA  B 701 ( 2.8A)
PQQ  B 702 (-3.5A)
1.21A 4jdsB-4tqoB:
undetectable
4jdsB-4tqoB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 268
GLY B 210
THR B 305
ASN B 289
GLY B 286
None
None
None
CA  B 701 ( 2.8A)
None
1.07A 4n48A-4tqoB:
undetectable
4n48A-4tqoB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 268
GLY B 210
THR B 305
ASN B 289
GLY B 286
None
None
None
CA  B 701 ( 2.8A)
None
1.05A 4n48B-4tqoB:
undetectable
4n48B-4tqoB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B  87
LEU B 139
GLY B 138
THR B  46
ILE B 424
None
1.31A 4oktA-4tqoB:
undetectable
4oktA-4tqoB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
THR B 364
SER B 341
GLY B 339
None
1.08A 4q15A-4tqoB:
undetectable
4q15A-4tqoB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 PHE B 376
VAL B 388
THR B 364
SER B 341
GLY B 339
None
1.37A 4q15A-4tqoB:
undetectable
4q15A-4tqoB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
THR B 364
SER B 341
GLY B 339
None
1.14A 4q15B-4tqoB:
undetectable
4q15B-4tqoB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvmV-4tqoB:
undetectable
4qvmb-4tqoB:
undetectable
4qvmV-4tqoB:
19.58
4qvmb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvmH-4tqoB:
undetectable
4qvmN-4tqoB:
undetectable
4qvmH-4tqoB:
19.58
4qvmN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 4qvnV-4tqoB:
undetectable
4qvnb-4tqoB:
undetectable
4qvnV-4tqoB:
19.58
4qvnb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvnH-4tqoB:
undetectable
4qvnN-4tqoB:
undetectable
4qvnH-4tqoB:
19.58
4qvnN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvpV-4tqoB:
undetectable
4qvpb-4tqoB:
undetectable
4qvpV-4tqoB:
19.58
4qvpb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvpH-4tqoB:
undetectable
4qvpN-4tqoB:
undetectable
4qvpH-4tqoB:
19.58
4qvpN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 4qvqV-4tqoB:
undetectable
4qvqb-4tqoB:
undetectable
4qvqV-4tqoB:
19.58
4qvqb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 4qvqH-4tqoB:
undetectable
4qvqN-4tqoB:
undetectable
4qvqH-4tqoB:
19.58
4qvqN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qvwV-4tqoB:
undetectable
4qvwb-4tqoB:
undetectable
4qvwV-4tqoB:
19.58
4qvwb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.07A 4qvwH-4tqoB:
undetectable
4qvwN-4tqoB:
undetectable
4qvwH-4tqoB:
19.58
4qvwN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 4qw0V-4tqoB:
undetectable
4qw0b-4tqoB:
undetectable
4qw0V-4tqoB:
19.58
4qw0b-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 4qw0H-4tqoB:
undetectable
4qw0N-4tqoB:
undetectable
4qw0H-4tqoB:
19.58
4qw0N-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.11A 4qw1V-4tqoB:
undetectable
4qw1b-4tqoB:
undetectable
4qw1V-4tqoB:
19.58
4qw1b-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.11A 4qw1H-4tqoB:
undetectable
4qw1N-4tqoB:
undetectable
4qw1H-4tqoB:
19.58
4qw1N-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qw3V-4tqoB:
undetectable
4qw3b-4tqoB:
undetectable
4qw3V-4tqoB:
19.58
4qw3b-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qw3H-4tqoB:
undetectable
4qw3N-4tqoB:
undetectable
4qw3H-4tqoB:
19.58
4qw3N-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.07A 4qwuV-4tqoB:
undetectable
4qwub-4tqoB:
undetectable
4qwuV-4tqoB:
19.58
4qwub-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 4qwuH-4tqoB:
undetectable
4qwuN-4tqoB:
undetectable
4qwuH-4tqoB:
19.58
4qwuN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 210
GLY B 268
GLY B 203
ALA B 204
ILE B 180
None
None
PQQ  B 702 (-3.1A)
PQQ  B 702 (-3.0A)
None
0.95A 4rtmA-4tqoB:
undetectable
4rtmA-4tqoB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 TRP B 309
THR B 307
GLY B 267
ARG B 209
LEU B 235
None
1.37A 4uinH-4tqoB:
undetectable
4uinL-4tqoB:
undetectable
4uinH-4tqoB:
16.90
4uinL-4tqoB:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 4 TYR B 211
THR B 213
GLY B 200
LEU B 186
None
1.28A 4w5nA-4tqoB:
undetectable
4w5nA-4tqoB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
4 / 5 TYR I  23
LYS I  38
PRO I  39
GLU B 295
None
1.27A 4w5tA-4tqoI:
undetectable
4w5tA-4tqoI:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
VAL B 388
SER B 341
GLY B 339
None
1.20A 4ydqA-4tqoB:
undetectable
4ydqA-4tqoB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
4 / 6 TYR I  23
LYS I  38
PRO I  39
GLU B 295
None
1.28A 4z4cA-4tqoI:
undetectable
4z4cA-4tqoI:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT
METHANOL
DEHYDROGENASE, SMALL
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus)
4 / 6 TYR I  23
LYS I  38
PRO I  39
GLU B 295
None
1.24A 4z4gA-4tqoI:
undetectable
4z4gA-4tqoI:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 ALA B 204
GLY B 267
GLY B 286
ASN B 289
TRP B 271
PQQ  B 702 (-3.0A)
None
None
CA  B 701 ( 2.8A)
PQQ  B 702 (-3.5A)
1.27A 5ayfA-4tqoB:
undetectable
5ayfA-4tqoB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 5cz7H-4tqoB:
undetectable
5cz7N-4tqoB:
undetectable
5cz7H-4tqoB:
19.58
5cz7N-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.10A 5d0xV-4tqoB:
undetectable
5d0xb-4tqoB:
undetectable
5d0xV-4tqoB:
19.58
5d0xb-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.09A 5d0xH-4tqoB:
undetectable
5d0xN-4tqoB:
undetectable
5d0xH-4tqoB:
19.58
5d0xN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 ASP B 514
LEU B 527
ARG B 520
None
0.92A 5e8qA-4tqoB:
undetectable
5e8qA-4tqoB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 4 LEU B 513
LEU B 473
GLY B 474
GLU B 492
None
1.05A 5hhjA-4tqoB:
undetectable
5hhjA-4tqoB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 VAL B 382
HIS B 420
VAL B 438
None
0.66A 5jmnC-4tqoB:
undetectable
5jmnC-4tqoB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 5l5zH-4tqoB:
undetectable
5l5zN-4tqoB:
undetectable
5l5zH-4tqoB:
19.58
5l5zN-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 5l66V-4tqoB:
undetectable
5l66b-4tqoB:
undetectable
5l66V-4tqoB:
19.58
5l66b-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.08A 5l66H-4tqoB:
undetectable
5l66N-4tqoB:
undetectable
5l66H-4tqoB:
19.58
5l66N-4tqoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 TYR B 322
ALA B 375
TYR B 363
None
0.80A 5uunB-4tqoB:
undetectable
5uunB-4tqoB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
VAL B 388
SER B 341
GLY B 339
None
1.25A 5xiqA-4tqoB:
undetectable
5xiqA-4tqoB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 LYS B 518
LEU B 527
ARG B 520
None
0.94A 5yw0A-4tqoB:
undetectable
5yw0A-4tqoB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
3 / 3 MET B 306
ASP B 331
ARG B 137
None
CA  B 701 ( 3.1A)
PQQ  B 702 (-3.0A)
1.19A 5z6kA-4tqoB:
undetectable
5z6kA-4tqoB:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 10 GLY B 288
GLY B 334
ASP B 331
THR B 305
ASN B 302
None
None
CA  B 701 ( 3.1A)
None
None
1.20A 6exiA-4tqoB:
undetectable
6exiA-4tqoB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 10 GLY B 288
GLY B 334
ASP B 331
THR B 305
ASN B 302
None
None
CA  B 701 ( 3.1A)
None
None
1.20A 6exiB-4tqoB:
undetectable
6exiB-4tqoB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 GLY B 288
GLY B 334
ASP B 331
THR B 305
ASN B 302
None
None
CA  B 701 ( 3.1A)
None
None
1.19A 6exiC-4tqoB:
undetectable
6exiD-4tqoB:
undetectable
6exiC-4tqoB:
10.45
6exiD-4tqoB:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 6 TYR B 401
VAL B 382
LYS B 377
VAL B 385
None
1.44A 6f32B-4tqoB:
undetectable
6f32B-4tqoB:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.10A 6hwdV-4tqoB:
undetectable
6hwdb-4tqoB:
undetectable
6hwdV-4tqoB:
9.72
6hwdb-4tqoB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 HIS B 160
THR B 185
ARG B 225
GLY B 200
THR B 213
None
1.10A 6hwdH-4tqoB:
undetectable
6hwdN-4tqoB:
undetectable
6hwdH-4tqoB:
9.72
6hwdN-4tqoB:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 11 GLY B 578
GLY B 576
VAL B 564
MET B 465
ASP B 331
None
None
None
None
CA  B 701 ( 3.1A)
1.09A 6i5zD-4tqoB:
undetectable
6i5zD-4tqoB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
4 / 7 TRP B  42
ARG B  40
HIS B 546
ASP B  38
None
1.36A 6mn4E-4tqoB:
undetectable
6mn4E-4tqoB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus)
5 / 12 LEU B 390
PHE B 376
VAL B 388
SER B 341
GLY B 339
None
1.25A 6mn8A-4tqoB:
undetectable
6mn8A-4tqoB:
21.90