SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tqx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4tqx SORTASE
(Streptococcus
mutans) 		5 / 12 ILE A 244
ILE A 103
LEU A 105
THR A 204
HIS A 140
 None
 1.07A 2qo5A-4tqxA:
undetectable		 2qo5A-4tqxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4tqx SORTASE
(Streptococcus
mutans) 		4 / 8 PHE A 152
ILE A 103
PHE A 108
GLY A  95
 None
 0.92A 2qwxA-4tqxA:
undetectable
2qwxB-4tqxA:
undetectable		 2qwxA-4tqxA:
20.32
2qwxB-4tqxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 4tqx SORTASE
(Streptococcus
mutans) 		4 / 5 HIS A 217
VAL A 216
GLU A 179
VAL A 190
 ACY  A 302 (-3.9A)
None
ACY  A 302 ( 4.7A)
ACY  A 302 (-3.9A)
 1.26A 4p6vB-4tqxA:
undetectable
4p6vE-4tqxA:
undetectable		 4p6vB-4tqxA:
19.06
4p6vE-4tqxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4tqx SORTASE
(Streptococcus
mutans) 		4 / 8 PHE A 152
ILE A 103
PHE A 108
GLY A  95
 None
 0.87A 4qogA-4tqxA:
undetectable
4qogB-4tqxA:
undetectable		 4qogA-4tqxA:
20.32
4qogB-4tqxA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4tqx SORTASE
(Streptococcus
mutans) 		4 / 6 PHE A 108
PRO A  91
THR A 122
ILE A  93
 None
 1.39A 5ih0A-4tqxA:
undetectable		 5ih0A-4tqxA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4tqx SORTASE
(Streptococcus
mutans) 		3 / 3 ASP A 100
ASN A 104
GLN A 239
 None
 0.80A 5k7uA-4tqxA:
undetectable		 5k7uA-4tqxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4tqx SORTASE
(Streptococcus
mutans) 		5 / 10 ALA A 135
LEU A 136
LEU A 166
GLU A 199
ILE A 164
 None
None
None
ACY  A 302 ( 4.9A)
None
 0.69A 5v02B-4tqxA:
undetectable
5v02R-4tqxA:
undetectable		 5v02B-4tqxA:
18.45
5v02R-4tqxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4tqx SORTASE
(Streptococcus
mutans) 		5 / 9 LEU A 155
VAL A 216
ILE A 164
ILE A  98
ASP A 100
 None
 1.23A 5yf9X-4tqxA:
undetectable		 5yf9X-4tqxA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4tqx SORTASE
(Streptococcus
mutans) 		4 / 7 GLY A 218
TYR A 175
GLU A 131
GLY A 130
 None
 0.86A 6n7fA-4tqxA:
undetectable		 6n7fA-4tqxA:
20.00