SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM6_D_BRLD503_2 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	4tr1	GLUTAREDOXIN 3 (Alkaliphilus oremlandii)	4 / 4	ILE A 69 LEU A 84 VAL A 27 ILE A 4	CSO A 66 ( 4.4A) None None None	0.94A	1fm6D-4tr1A: undetectable	1fm6D-4tr1A: 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_P_CHDP1525_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 3)	4tr1	GLUTAREDOXIN 3 (Alkaliphilus oremlandii)	4 / 7	ASP A 33 THR A 8 TYR A 7 HIS A 70	None None None CSO A 66 ( 3.9A)	1.47A	3ag3N-4tr1A: undetectable 3ag3P-4tr1A: undetectable	3ag3N-4tr1A: 10.34 3ag3P-4tr1A: 16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N3I_A_ROCA201_2 (PROTEASE)	4tr1	GLUTAREDOXIN 3 (Alkaliphilus oremlandii)	4 / 6	ILE A 77 ASP A 28 GLY A 83 VAL A 56	None	0.92A	3n3iA-4tr1A: undetectable	3n3iA-4tr1A: 15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R9V_B_DXCB323_0 (INVASIN IPAD)	4tr1	GLUTAREDOXIN 3 (Alkaliphilus oremlandii)	5 / 7	ILE A 4 ILE A 6 VAL A 19 LEU A 22 SER A 23	None	0.89A	3r9vA-4tr1A: undetectable 3r9vB-4tr1A: undetectable	3r9vA-4tr1A: 15.44 3r9vB-4tr1A: 15.44

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1FM6_D_BRLD503_2","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","4tr1","GLUTAREDOXIN 3","Alkaliphilus oremlandii",4,"ILE A  69;LEU A  84;VAL A  27;ILE A   4","CSO A  66 ( 4.4A);None;None;None","0.94A","1fm6D-4tr1A:undetectable","1fm6D-4tr1A:16.41"],["3AG3_P_CHDP1525_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 3","4tr1","GLUTAREDOXIN 3","Alkaliphilus oremlandii",4,"ASP A  33;THR A   8;TYR A   7;HIS A  70","None;None;None;CSO A  66 ( 3.9A)","1.47A","3ag3N-4tr1A:undetectable;3ag3P-4tr1A:undetectable","3ag3N-4tr1A:10.34;3ag3P-4tr1A:16.87"],["3N3I_A_ROCA201_2","PROTEASE","4tr1","GLUTAREDOXIN 3","Alkaliphilus oremlandii",4,"ILE A  77;ASP A  28;GLY A  83;VAL A  56","None","0.92A","3n3iA-4tr1A:undetectable","3n3iA-4tr1A:15.92"],["3R9V_B_DXCB323_0","INVASIN IPAD","4tr1","GLUTAREDOXIN 3","Alkaliphilus oremlandii",5,"ILE A   4;ILE A   6;VAL A  19;LEU A  22;SER A  23","None","0.89A","3r9vA-4tr1A:undetectable;3r9vB-4tr1A:undetectable","3r9vA-4tr1A:15.44;3r9vB-4tr1A:15.44"]]