SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 7 LEU A 142
LEU A 192
GLY A 190
LEU A 186
 None
None
CA  A 802 (-3.5A)
None
 0.93A 1gtiA-4tr2A:
undetectable		 1gtiA-4tr2A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 8 TYR A 534
LEU A 286
LEU A 290
GLU A 282
 None
 1.05A 1i7zA-4tr2A:
undetectable		 1i7zA-4tr2A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 7 MET A 367
ASP A 368
ASP A 369
HIS A 408
 None
 1.22A 1t03A-4tr2A:
undetectable		 1t03A-4tr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 4 HIS A 372
ASP A 406
ASN A 361
ASP A 316
 None
 1.39A 1wg8A-4tr2A:
2.3		 1wg8A-4tr2A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 7 PHE A 437
LEU A 490
VAL A 127
SER A 165
 None
 1.05A 1wrlA-4tr2A:
undetectable
1wrlB-4tr2A:
undetectable		 1wrlA-4tr2A:
7.68
1wrlB-4tr2A:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 11 GLY A 433
LEU A 405
HIS A 372
ILE A 380
ALA A 556
 None
 1.41A 2a58A-4tr2A:
2.9
2a58E-4tr2A:
3.0		 2a58A-4tr2A:
12.48
2a58E-4tr2A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 11 ILE A 380
ALA A 556
GLY A 433
LEU A 405
HIS A 372
 None
 1.40A 2a58C-4tr2A:
3.0
2a58D-4tr2A:
2.3		 2a58C-4tr2A:
12.48
2a58D-4tr2A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 11 ILE A 558
ALA A 581
ASN A 605
LEU A 606
ILE A 302
 None
 1.03A 2aclE-4tr2A:
undetectable		 2aclE-4tr2A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 LYS A 544
ASP A  79
ASN A  75
 None
 1.09A 2bm9A-4tr2A:
undetectable		 2bm9A-4tr2A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 LEU A 545
GLY A 373
TYR A 371
SER A 535
ASP A 368
 None
 1.04A 2br4D-4tr2A:
undetectable		 2br4D-4tr2A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 6 SER A 587
LEU A 585
SER A 512
ASP A 506
 None
 1.08A 2j2pE-4tr2A:
undetectable
2j2pF-4tr2A:
undetectable		 2j2pE-4tr2A:
15.37
2j2pF-4tr2A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 SER A 552
SER A 549
ASN A 370
ASN A 432
VAL A  64
 None
 1.27A 2nniA-4tr2A:
undetectable		 2nniA-4tr2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 ALA A 559
VAL A 575
ILE A 498
ILE A 431
ILE A 574
 None
 0.97A 2pynB-4tr2A:
undetectable		 2pynB-4tr2A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 LEU A 526
VAL A 500
GLY A 596
LEU A 503
ALA A 528
 None
 1.00A 2v3kA-4tr2A:
undetectable		 2v3kA-4tr2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 LEU A 292
SER A 434
SER A 461
ASN A 432
ALA A 551
 None
 1.45A 2vdmA-4tr2A:
undetectable
2vdmB-4tr2A:
4.1		 2vdmA-4tr2A:
22.51
2vdmB-4tr2A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 ASP A 316
VAL A 376
SER A 461
SER A 552
ASN A 464
 None
 1.44A 2y03B-4tr2A:
undetectable		 2y03B-4tr2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 MET A 550
ALA A 551
VAL A 314
ASP A 316
ILE A 379
 None
 1.23A 3a65A-4tr2A:
undetectable		 3a65A-4tr2A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 ILE A 489
LEU A 490
PRO A 553
THR A 548
VAL A 497
 None
 1.08A 3dcjA-4tr2A:
2.5
3dcjB-4tr2A:
2.7		 3dcjA-4tr2A:
15.69
3dcjB-4tr2A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 4 LEU A  50
MET A 174
ILE A 443
ASP A  39
 None
 1.08A 3hecA-4tr2A:
undetectable		 3hecA-4tr2A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 ALA A 559
VAL A 575
ILE A 498
ILE A 431
ILE A 574
 None
 0.96A 3nu6A-4tr2A:
undetectable		 3nu6A-4tr2A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 9 GLY A 200
ALA A 201
ASP A 202
GLY A 433
ILE A 315
 None
 0.99A 3ogpA-4tr2A:
undetectable		 3ogpA-4tr2A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 7 VAL A 127
LEU A 186
TYR A 182
LEU A  47
 None
 0.95A 3qeoB-4tr2A:
undetectable		 3qeoB-4tr2A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 HIS A 372
ASP A 316
GLY A 547
SER A 549
ALA A 201
 None
 0.99A 3sufD-4tr2A:
undetectable		 3sufD-4tr2A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 ASN A 333
ASP A 346
ASN A 348
 CA  A 803 ( 4.9A)
CA  A 803 (-3.2A)
CA  A 803 (-2.8A)
 0.79A 4agaA-4tr2A:
undetectable		 4agaA-4tr2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 ASN A 348
ASP A 353
ASN A 333
 CA  A 803 (-2.8A)
CA  A 803 (-3.1A)
CA  A 803 ( 4.9A)
 0.65A 4agaA-4tr2A:
undetectable		 4agaA-4tr2A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 SER A 564
ASP A 394
GLN A 299
 None
None
PO4  A 806 ( 4.2A)
 0.89A 4oltA-4tr2A:
0.4
4oltB-4tr2A:
0.4		 4oltA-4tr2A:
17.39
4oltB-4tr2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 GLN A 299
SER A 564
ASP A 394
 PO4  A 806 ( 4.2A)
None
None
 0.80A 4qwpA-4tr2A:
0.3
4qwpB-4tr2A:
0.4		 4qwpA-4tr2A:
17.24
4qwpB-4tr2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		6 / 12 ALA A 293
ALA A 528
LEU A 399
ALA A 557
ASP A 394
GLY A 395
 None
 1.26A 4v04A-4tr2A:
undetectable		 4v04A-4tr2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		6 / 12 ALA A 293
ALA A 528
LEU A 399
ALA A 557
ASP A 394
GLY A 395
 None
 1.29A 4v04B-4tr2A:
undetectable		 4v04B-4tr2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 9 LEU A 170
LEU A 186
ILE A 193
SER A 184
ALA A 180
 None
 1.23A 4z69A-4tr2A:
undetectable		 4z69A-4tr2A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 6 LEU A 480
ALA A 499
SER A 593
VAL A 497
 None
 1.09A 5a6iA-4tr2A:
undetectable		 5a6iA-4tr2A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 THR A 531
ALA A  73
ASN A 532
 None
 0.49A 5ersA-4tr2A:
4.2		 5ersA-4tr2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		4 / 6 GLY A 547
THR A 548
VAL A  67
HIS A 372
 None
 1.02A 5ewuB-4tr2A:
undetectable		 5ewuB-4tr2A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		3 / 3 THR A 548
SER A 461
ASP A 316
 None
 0.71A 5kvaA-4tr2A:
undetectable		 5kvaA-4tr2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 ILE A 558
VAL A 562
LEU A 503
ALA A 527
TYR A 511
 None
 1.12A 6djzA-4tr2A:
undetectable		 6djzA-4tr2A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.33A 6dlzA-4tr2A:
6.2
6dlzD-4tr2A:
6.1		 6dlzA-4tr2A:
8.65
6dlzD-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.33A 6dlzB-4tr2A:
6.2
6dlzC-4tr2A:
6.1		 6dlzB-4tr2A:
8.65
6dlzC-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 9 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.33A 6dm0A-4tr2A:
5.7
6dm0D-4tr2A:
6.2		 6dm0A-4tr2A:
8.65
6dm0D-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 9 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.33A 6dm0B-4tr2A:
5.9
6dm0C-4tr2A:
5.6		 6dm0B-4tr2A:
8.65
6dm0C-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.34A 6dm1A-4tr2A:
5.9
6dm1D-4tr2A:
5.6		 6dm1A-4tr2A:
8.65
6dm1D-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 10 PRO A 529
MET A 550
LEU A 513
SER A 517
ASP A 202
 None
 1.33A 6dm1B-4tr2A:
5.8
6dm1C-4tr2A:
6.1		 6dm1B-4tr2A:
8.65
6dm1C-4tr2A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE
(Plasmodium
vivax) 		5 / 12 LEU A 413
PHE A 435
ASP A 316
GLY A 433
PHE A 458
 None
 1.29A 6dwnA-4tr2A:
undetectable		 6dwnA-4tr2A:
8.02