SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		3 / 3 ILE A 115
ASP A 124
PHE A 125
 None
 0.59A 1uwjB-4tr4A:
undetectable		 1uwjB-4tr4A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 5 TYR A 262
ILE A 269
ARG A 275
GLY A 274
 None
 1.18A 1ve9A-4tr4A:
2.7		 1ve9A-4tr4A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 5 GLY A 255
PRO A 136
ALA A 135
ILE A 269
 None
 0.91A 2aofA-4tr4A:
undetectable		 2aofA-4tr4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 5 TYR A 262
ILE A 269
ARG A 275
GLY A 274
 None
 1.19A 2du8G-4tr4A:
2.4		 2du8G-4tr4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 5 TYR A 262
ILE A 269
ARG A 275
GLY A 274
 None
 1.22A 2du8J-4tr4A:
2.5		 2du8J-4tr4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 VAL A 162
VAL A 263
LEU A 289
TRP A 288
 None
 0.81A 2gehA-4tr4A:
undetectable		 2gehA-4tr4A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 TYR A 292
TRP A 288
ARG A 291
GLN A 295
 None
 1.30A 2vxaA-4tr4A:
undetectable
2vxaC-4tr4A:
undetectable
2vxaE-4tr4A:
undetectable		 2vxaA-4tr4A:
15.47
2vxaC-4tr4A:
15.47
2vxaE-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.30A 2vxaA-4tr4A:
undetectable
2vxaB-4tr4A:
undetectable
2vxaK-4tr4A:
undetectable		 2vxaA-4tr4A:
15.47
2vxaB-4tr4A:
15.47
2vxaK-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.29A 2vxaB-4tr4A:
undetectable
2vxaC-4tr4A:
undetectable
2vxaG-4tr4A:
undetectable		 2vxaB-4tr4A:
15.47
2vxaC-4tr4A:
15.47
2vxaG-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 TYR A 292
TRP A 288
ARG A 291
GLN A 295
 None
 1.30A 2vxaD-4tr4A:
undetectable
2vxaF-4tr4A:
undetectable
2vxaI-4tr4A:
undetectable		 2vxaD-4tr4A:
15.47
2vxaF-4tr4A:
15.47
2vxaI-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.32A 2vxaD-4tr4A:
undetectable
2vxaE-4tr4A:
undetectable
2vxaL-4tr4A:
undetectable		 2vxaD-4tr4A:
15.47
2vxaE-4tr4A:
15.47
2vxaL-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.29A 2vxaB-4tr4A:
undetectable
2vxaG-4tr4A:
undetectable
2vxaH-4tr4A:
undetectable		 2vxaB-4tr4A:
15.47
2vxaG-4tr4A:
15.47
2vxaH-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.29A 2vxaH-4tr4A:
undetectable
2vxaI-4tr4A:
undetectable
2vxaJ-4tr4A:
undetectable		 2vxaH-4tr4A:
15.47
2vxaI-4tr4A:
15.47
2vxaJ-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 TYR A 292
TRP A 288
ARG A 291
GLN A 295
 None
 1.30A 2vxaD-4tr4A:
undetectable
2vxaJ-4tr4A:
undetectable
2vxaL-4tr4A:
undetectable		 2vxaD-4tr4A:
15.47
2vxaJ-4tr4A:
15.47
2vxaL-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.30A 2vxaH-4tr4A:
undetectable
2vxaJ-4tr4A:
undetectable
2vxaK-4tr4A:
undetectable		 2vxaH-4tr4A:
15.47
2vxaJ-4tr4A:
15.47
2vxaK-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 ARG A 291
GLN A 295
TYR A 292
TRP A 288
 None
 1.32A 2vxaA-4tr4A:
undetectable
2vxaK-4tr4A:
undetectable
2vxaL-4tr4A:
undetectable		 2vxaA-4tr4A:
15.47
2vxaK-4tr4A:
15.47
2vxaL-4tr4A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 7 ILE A 264
LEU A 163
ALA A 135
ALA A 155
 None
 0.77A 4g77A-4tr4A:
undetectable		 4g77A-4tr4A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 6 ASN A 248
GLU A 200
TYR A 197
LEU A 243
 None
 1.16A 4twdI-4tr4A:
undetectable
4twdJ-4tr4A:
undetectable		 4twdI-4tr4A:
19.74
4twdJ-4tr4A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		5 / 12 VAL A 282
GLN A 281
ALA A 175
LEU A 232
ILE A 198
 None
 1.14A 5hv1A-4tr4A:
undetectable		 5hv1A-4tr4A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4tr4 TYPE III
IODOTHYRONINE
DEIODINASE
(Mus
musculus) 		4 / 8 VAL A 162
VAL A 263
LEU A 289
TRP A 288
 None
 0.78A 5tt3F-4tr4A:
undetectable		 5tt3F-4tr4A:
22.66