SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.88A 11gsA-4tr6A:
undetectable		 11gsA-4tr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 10 VAL A  23
VAL A  16
ILE A  31
TYR A 125
GLY A  48
 None
 1.29A 13gsA-4tr6A:
undetectable		 13gsA-4tr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 VAL A  23
VAL A  16
ILE A  31
TYR A 125
GLY A  48
 None
 1.29A 13gsB-4tr6A:
undetectable		 13gsB-4tr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		3 / 3 VAL A 203
VAL A 171
TRP A 169
 None
 1.00A 1av2A-4tr6A:
undetectable
1av2B-4tr6A:
undetectable		 1av2A-4tr6A:
4.42
1av2B-4tr6A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 GLY A 325
ALA A 296
THR A 264
ILE A 323
GLY A 355
 None
 1.21A 1c9sQ-4tr6A:
undetectable
1c9sR-4tr6A:
undetectable		 1c9sQ-4tr6A:
14.11
1c9sR-4tr6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 GLY A 355
GLY A 325
ALA A 296
THR A 264
ILE A 323
 None
 1.21A 1gtfD-4tr6A:
undetectable
1gtfE-4tr6A:
undetectable		 1gtfD-4tr6A:
14.11
1gtfE-4tr6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 GLY A 325
ALA A 296
THR A 264
ILE A 323
GLY A 355
 None
 1.22A 1gtfR-4tr6A:
undetectable
1gtfS-4tr6A:
undetectable		 1gtfR-4tr6A:
14.11
1gtfS-4tr6A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.82A 1ictB-4tr6A:
undetectable		 1ictB-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 PHE A  84
VAL A  88
LEU A  91
PHE A  46
 None
 1.03A 1wrlB-4tr6A:
undetectable		 1wrlB-4tr6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 8 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.91A 2gssA-4tr6A:
undetectable		 2gssA-4tr6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 8 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.92A 2gssB-4tr6A:
undetectable		 2gssB-4tr6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 11 SER A 352
LEU A 344
VAL A 343
ILE A 370
ALA A 180
 None
 1.23A 2zbzA-4tr6A:
undetectable		 2zbzA-4tr6A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.99A 3cfqA-4tr6A:
undetectable		 3cfqA-4tr6A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 8 ALA A 122
ASP A 123
ASP A 121
THR A 106
ILE A  77
 None
 1.47A 3el0A-4tr6A:
undetectable		 3el0A-4tr6A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.90A 3gssA-4tr6A:
undetectable		 3gssA-4tr6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.93A 3gssB-4tr6A:
undetectable		 3gssB-4tr6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 8 VAL A  23
ILE A  31
TYR A 125
GLY A  48
 None
 0.93A 3n9jA-4tr6A:
undetectable		 3n9jA-4tr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 12 ASP A 121
ILE A  31
ILE A  87
ALA A 122
TYR A 125
 None
 1.18A 3ohtA-4tr6A:
undetectable
3ohtB-4tr6A:
undetectable		 3ohtA-4tr6A:
22.57
3ohtB-4tr6A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 PHE A   5
MET A   3
ILE A 108
VAL A  96
 None
 0.92A 3p6hA-4tr6A:
undetectable		 3p6hA-4tr6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 12 GLY A  34
SER A  49
PRO A 126
LEU A  20
PHE A  84
 None
 1.48A 3r24A-4tr6A:
undetectable		 3r24A-4tr6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.60A 4d7bB-4tr6A:
undetectable		 4d7bB-4tr6A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 375
LEU A 373
ILE A 258
THR A 181
 None
 0.85A 4do3B-4tr6A:
undetectable		 4do3B-4tr6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 11 ALA A 320
ILE A 266
ILE A 362
LEU A 341
ILE A 349
 None
 1.07A 4dt8A-4tr6A:
undetectable		 4dt8A-4tr6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 10 ALA A 320
ILE A 266
ILE A 362
LEU A 341
ILE A 349
 None
 1.10A 4dt8B-4tr6A:
undetectable		 4dt8B-4tr6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 10 ALA A 320
ILE A 266
ILE A 362
LEU A 341
ILE A 349
 None
 1.07A 4dtaA-4tr6A:
undetectable		 4dtaA-4tr6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.65A 4i89A-4tr6A:
undetectable		 4i89A-4tr6A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 ILE A  98
ILE A  59
SER A  15
PHE A  84
 None
 0.90A 4m51A-4tr6A:
undetectable		 4m51A-4tr6A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 8 SER A  49
SER A  54
TYR A 125
GLU A  56
 None
 1.25A 4ms4A-4tr6A:
undetectable		 4ms4A-4tr6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 5 ILE A 216
LEU A 217
GLU A 212
VAL A 152
 None
 0.82A 4nkxB-4tr6A:
undetectable		 4nkxB-4tr6A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.62A 4pwjB-4tr6A:
undetectable		 4pwjB-4tr6A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 PHE A   5
ILE A  87
LEU A  79
PHE A  84
 None
 0.81A 4uymA-4tr6A:
undetectable		 4uymA-4tr6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 PHE A   5
ILE A  87
LEU A  79
PHE A  84
 None
 0.81A 4uymB-4tr6A:
undetectable		 4uymB-4tr6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.66A 5bojB-4tr6A:
undetectable		 5bojB-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 LEU A 164
THR A 181
PRO A 252
LEU A 373
 None
 0.63A 5fxtA-4tr6A:
37.9		 5fxtA-4tr6A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 8 THR A 181
LEU A 186
PRO A 252
PRO A 359
 None
 0.73A 5g48A-4tr6A:
37.7		 5g48A-4tr6A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		6 / 9 LEU A 164
THR A 181
LEU A 186
PRO A 252
PRO A 359
LEU A 373
 None
 0.80A 5g48B-4tr6A:
37.7		 5g48B-4tr6A:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 ALA A 122
ASP A 123
ASP A 121
GLY A  75
THR A 106
 None
 1.19A 5kr2A-4tr6A:
undetectable		 5kr2A-4tr6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 9 ALA A 122
ASP A 123
ASP A 121
GLY A  75
THR A 106
 None
 1.17A 5kr2C-4tr6A:
undetectable		 5kr2C-4tr6A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.66A 5l4iA-4tr6A:
undetectable		 5l4iA-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 6 LEU A 373
LEU A 361
SER A 352
THR A 354
 None
 0.66A 5l4iB-4tr6A:
undetectable		 5l4iB-4tr6A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		5 / 12 ILE A 304
PHE A 273
ILE A 302
THR A 264
ALA A 356
 None
 1.10A 5vceA-4tr6A:
undetectable		 5vceA-4tr6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 4tr6 DNA POLYMERASE III
SUBUNIT BETA
(Bacillus
subtilis) 		4 / 7 GLN A 232
PHE A 235
VAL A 240
SER A 209
 None
 1.00A 6hu9S-4tr6A:
undetectable
6hu9q-4tr6A:
undetectable		 6hu9S-4tr6A:
13.75
6hu9q-4tr6A:
17.51