SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4trb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 6 TRP A 156
GLU A 157
ARG A 206
ILE A 200
 None
 1.24A 1nsiA-4trbA:
undetectable
1nsiB-4trbA:
undetectable		 1nsiA-4trbA:
18.29
1nsiB-4trbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		5 / 12 LEU A  53
VAL A  52
LEU A  21
THR A  19
ALA A  22
 None
 1.05A 2egvA-4trbA:
undetectable		 2egvA-4trbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.25A 2nsiA-4trbA:
undetectable
2nsiB-4trbA:
undetectable		 2nsiA-4trbA:
18.29
2nsiB-4trbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.20A 3e7gA-4trbA:
undetectable
3e7gB-4trbA:
undetectable		 3e7gA-4trbA:
20.44
3e7gB-4trbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 TRP A 156
GLU A 157
ARG A 206
ILE A 200
 None
 1.18A 3e7gA-4trbA:
undetectable
3e7gB-4trbA:
undetectable		 3e7gA-4trbA:
20.44
3e7gB-4trbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.24A 3e7gC-4trbA:
undetectable
3e7gD-4trbA:
undetectable		 3e7gC-4trbA:
20.44
3e7gD-4trbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 8 TRP A 156
GLU A 157
ARG A 206
ILE A 200
 None
 1.21A 3e7gC-4trbA:
undetectable
3e7gD-4trbA:
undetectable		 3e7gC-4trbA:
20.44
3e7gD-4trbA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		5 / 12 PHE A 184
LEU A 180
ARG A 170
LEU A 167
LEU A 201
 None
 1.08A 3k2hA-4trbA:
undetectable		 3k2hA-4trbA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 8 TRP A 148
VAL A   6
TYR A 151
ILE A 190
 None
 0.99A 4afgD-4trbA:
0.9
4afgE-4trbA:
undetectable		 4afgD-4trbA:
21.54
4afgE-4trbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 8 TRP A 156
GLU A 157
ARG A 206
ILE A 200
 None
 1.30A 4cx7A-4trbA:
undetectable
4cx7B-4trbA:
undetectable		 4cx7A-4trbA:
18.29
4cx7B-4trbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 8 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.27A 4cx7C-4trbA:
undetectable
4cx7D-4trbA:
undetectable		 4cx7C-4trbA:
18.29
4cx7D-4trbA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 ARG A 206
ILE A 200
TRP A 156
GLU A 157
 None
 1.29A 4nosC-4trbA:
undetectable
4nosD-4trbA:
undetectable		 4nosC-4trbA:
20.29
4nosD-4trbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)
(Sulfolobus
solfataricus) 		4 / 7 TYR A 127
GLU A 142
PRO A 136
PHE A 149
 None
 1.18A 5aclA-4trbA:
undetectable		 5aclA-4trbA:
18.84