SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4trg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 6 ILE A 150
ASN A 458
SER A 154
ASN A 156
 None
 1.11A 1h7xA-4trgA:
undetectable		 1h7xA-4trgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 6 ILE A 150
ASN A 458
SER A 154
ASN A 156
 None
 1.10A 1h7xB-4trgA:
undetectable		 1h7xB-4trgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 6 ILE A 150
ASN A 458
SER A 154
ASN A 156
 None
 1.11A 1h7xC-4trgA:
undetectable		 1h7xC-4trgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 6 ILE A 150
ASN A 458
SER A 154
ASN A 156
 None
 1.10A 1h7xD-4trgA:
undetectable		 1h7xD-4trgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 ALA A 316
VAL A 318
TRP A 323
 None
 0.81A 1kqeA-4trgA:
undetectable
1kqeE-4trgA:
undetectable		 1kqeA-4trgA:
3.05
1kqeE-4trgA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 ALA A 316
VAL A 318
TRP A 323
 None
 0.82A 1kqeB-4trgA:
undetectable
1kqeD-4trgA:
undetectable		 1kqeB-4trgA:
3.05
1kqeD-4trgA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 TRP A 323
ALA A 316
VAL A 318
 None
 0.81A 1kqeB-4trgA:
undetectable
1kqeD-4trgA:
undetectable		 1kqeB-4trgA:
3.05
1kqeD-4trgA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 TRP A 323
ALA A 316
VAL A 318
 None
 0.82A 1kqeA-4trgA:
undetectable
1kqeE-4trgA:
undetectable		 1kqeA-4trgA:
3.05
1kqeE-4trgA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4trg SIDC
(Legionella
pneumophila) 		4 / 5 GLU A  13
ASN A 506
VAL A 508
ARG A 108
 None
 1.27A 3amuA-4trgA:
undetectable		 3amuA-4trgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 CYH A 468
HIS A 469
PHE A 460
 None
 1.05A 3cr4X-4trgA:
undetectable		 3cr4X-4trgA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 8 GLY A 392
PRO A 401
GLN A 425
GLU A 400
 None
 0.77A 3s3mA-4trgA:
undetectable		 3s3mA-4trgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4trg SIDC
(Legionella
pneumophila) 		4 / 8 GLY A 392
PRO A 401
GLN A 425
GLU A 400
 None
 0.85A 3s3nA-4trgA:
undetectable		 3s3nA-4trgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4trg SIDC
(Legionella
pneumophila) 		4 / 4 TRP A 323
LEU A 263
LEU A 279
THR A 317
 None
 1.22A 4bboD-4trgA:
undetectable		 4bboD-4trgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 4trg SIDC
(Legionella
pneumophila) 		5 / 9 VAL A 300
LEU A 314
LEU A 252
LEU A 279
ILE A 256
 None
 1.31A 4ubsA-4trgA:
2.0		 4ubsA-4trgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 TYR A 292
ARG A 284
LYS A 286
 None
 1.12A 4wq5B-4trgA:
undetectable		 4wq5B-4trgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4trg SIDC
(Legionella
pneumophila) 		3 / 3 THR A 232
HIS A 236
ASN A 258
 None
 0.86A 5n4tA-4trgA:
undetectable		 5n4tA-4trgA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 4trg SIDC
(Legionella
pneumophila) 		5 / 10 LEU A 279
LEU A 314
GLU A 262
VAL A 233
ILE A 310
 None
 1.01A 5v02B-4trgA:
4.2
5v02R-4trgA:
undetectable		 5v02B-4trgA:
11.07
5v02R-4trgA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 4trg SIDC
(Legionella
pneumophila) 		4 / 5 GLU A  13
ASN A 506
VAL A 508
ARG A 108
 None
 1.24A 6aggZ-4trgA:
undetectable		 6aggZ-4trgA:
11.41