SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4trk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		3 / 3 CYH A  61
PHE A  75
PHE A  62
 None
 0.80A 3cr5X-4trkA:
undetectable		 3cr5X-4trkA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		4 / 8 ASP A 142
ASP A 247
ASP A 219
TYR A 214
 None
 1.25A 3havA-4trkA:
1.5		 3havA-4trkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		5 / 12 ILE A  50
ALA A  48
LEU A  57
ILE A 106
THR A  73
 None
 1.23A 3ql3A-4trkA:
undetectable		 3ql3A-4trkA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		5 / 10 SER A 136
ASN A 139
TYR A 214
ILE A 141
ALA A 240
 None
 1.38A 3u6tA-4trkA:
undetectable		 3u6tA-4trkA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		3 / 3 LYS A 110
LYS A 111
PRO A 112
 None
 1.19A 4dv1L-4trkA:
undetectable		 4dv1L-4trkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		4 / 7 PHE A  25
THR A  24
ILE A  67
PHE A 165
 None
 0.90A 4ejjA-4trkA:
undetectable		 4ejjA-4trkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		4 / 5 ASN A  34
ARG A  41
MET A  37
HIS A 233
 None
 1.32A 4g5jA-4trkA:
0.0		 4g5jA-4trkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		5 / 12 LEU A  92
PHE A 104
GLY A 280
ALA A 188
ILE A 106
 None
 1.09A 4nkxC-4trkA:
undetectable		 4nkxC-4trkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		5 / 12 LEU A  92
PHE A 104
GLY A 280
ALA A 188
ILE A 106
 None
 1.09A 4nkxD-4trkA:
undetectable		 4nkxD-4trkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		4 / 8 LEU A 182
LEU A  51
ILE A 225
MET A 179
 None
 0.89A 5ljbA-4trkA:
undetectable		 5ljbA-4trkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4trk C. ELEGANS HIM-3
(Caenorhabditis
elegans) 		5 / 12 PHE A 190
ILE A 285
PHE A 104
PHE A  75
THR A  73
 None
 1.27A 5vcgA-4trkA:
undetectable		 5vcgA-4trkA:
21.33