SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4trr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 ASP A  37
ASP A  63
ILE A 113
ILE A  93
THR A  65
 None
 1.44A 1kijA-4trrA:
undetectable		 1kijA-4trrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 ASP A 116
TYR A 140
LEU A 166
THR A 121
 None
 1.10A 1rmtD-4trrA:
5.0		 1rmtD-4trrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		7 / 11 GLY A  13
ALA A  15
SER A  16
ASP A  37
LEU A  38
ASP A  63
VAL A  64
 None
 0.62A 1uayA-4trrA:
28.6		 1uayA-4trrA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		7 / 10 GLY A  13
ALA A  15
SER A  16
ASP A  37
LEU A  38
ASP A  63
VAL A  64
 None
 0.66A 1uayB-4trrA:
29.2		 1uayB-4trrA:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 4 GLY A 142
SER A 146
ILE A 253
HIS A 147
 None
 1.18A 1yajJ-4trrA:
3.6		 1yajJ-4trrA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
LEU A  38
ASP A  63
VAL A  64
ILE A 113
 None
 0.90A 1zq9B-4trrA:
5.8		 1zq9B-4trrA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A  81
ILE A  35
ASN A  44
GLN A  40
 None
 0.84A 2a8tB-4trrA:
undetectable		 2a8tB-4trrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A  37
ASP A  41
ASP A  63
 None
 0.74A 2igtB-4trrA:
7.6		 2igtB-4trrA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
ALA A  15
LEU A  38
VAL A  64
THR A  65
 None
 0.73A 2nyuB-4trrA:
9.4		 2nyuB-4trrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		3 / 3 ASP A  37
ASP A  41
ASP A  63
 None
 0.78A 3douA-4trrA:
9.4		 3douA-4trrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
ASP A  37
LEU A  38
ASN A  39
ASP A  63
 None
 0.84A 3q87B-4trrA:
2.8		 3q87B-4trrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
ILE A  18
ASP A  37
LEU A  38
ASP A  63
 None
SO4  A 301 (-3.8A)
None
None
None
 1.17A 3q87B-4trrA:
2.8		 3q87B-4trrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  13
ILE A  22
ASP A  37
LEU A  38
ASP A  63
 None
 0.56A 3q87B-4trrA:
2.8		 3q87B-4trrA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  82
ASP A  85
ILE A  50
ALA A  31
ALA A  27
 None
 1.01A 3sudC-4trrA:
undetectable		 3sudC-4trrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 GLY A  82
ASP A  85
ILE A  50
ALA A  31
ALA A  27
 None
 1.03A 3sueA-4trrA:
undetectable		 3sueA-4trrA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 THR A 121
LEU A 163
ASP A 116
VAL A  64
 None
 0.97A 4cp4A-4trrA:
undetectable		 4cp4A-4trrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A 232
VAL A 236
LEU A 239
VAL A 137
 None
 0.85A 4e1gB-4trrA:
undetectable		 4e1gB-4trrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1103_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 5 ASN A 178
ARG A 134
HIS A 177
LEU A 126
 None
 1.29A 4g5jA-4trrA:
undetectable		 4g5jA-4trrA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A  60
ILE A  58
VAL A  10
ALA A  34
 None
 0.49A 5osrA-4trrA:
undetectable		 5osrA-4trrA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 12 THR A 228
THR A 227
VAL A 189
THR A 191
GLN A 234
 None
 1.23A 6ak3A-4trrA:
undetectable		 6ak3A-4trrA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE
(Burkholderia
cenocepacia) 		5 / 9 ALA A  23
ALA A  15
GLY A  19
ALA A  36
GLY A  13
 None
None
SO4  A 301 (-4.2A)
None
None
 1.18A 6bklE-4trrA:
undetectable
6bklF-4trrA:
undetectable
6bklG-4trrA:
undetectable
6bklH-4trrA:
undetectable		 6bklE-4trrA:
11.80
6bklF-4trrA:
11.80
6bklG-4trrA:
11.80
6bklH-4trrA:
11.80