SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4trt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 LEU A  43
VAL A  70
LEU A  96
LEU A  91
VAL A   6
 None
 1.09A 1sn5B-4trtA:
undetectable
1sn5D-4trtA:
undetectable		 1sn5B-4trtA:
17.07
1sn5D-4trtA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 LEU A  96
LEU A  91
VAL A   6
LEU A  43
VAL A  70
 None
 1.12A 1sn5B-4trtA:
undetectable
1sn5D-4trtA:
undetectable		 1sn5B-4trtA:
17.07
1sn5D-4trtA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 11 THR A  38
VAL A   6
VAL A  58
GLU A  88
LEU A  96
 None
 0.93A 1t6zA-4trtA:
undetectable		 1t6zA-4trtA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 11 THR A  38
VAL A   6
VAL A  58
GLU A  88
LEU A  96
 None
 1.19A 1t6zB-4trtA:
undetectable		 1t6zB-4trtA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		4 / 4 THR A 251
VAL A 280
GLY A 306
THR A 307
 None
 0.78A 3cflA-4trtA:
undetectable		 3cflA-4trtA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		6 / 12 ALA A 331
GLY A 348
GLY A 350
VAL A 250
PRO A 253
LEU A 257
 None
 1.49A 3m6vA-4trtA:
undetectable		 3m6vA-4trtA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		6 / 12 ALA A 331
GLY A 348
GLY A 350
VAL A 250
PRO A 253
LEU A 257
 None
 1.50A 3m6vB-4trtA:
undetectable		 3m6vB-4trtA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		6 / 12 ALA A 331
GLY A 348
GLY A 350
VAL A 250
PRO A 253
LEU A 257
 None
 1.49A 3m6wA-4trtA:
undetectable		 3m6wA-4trtA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 GLY A 352
ARG A 174
ILE A 156
ALA A 176
ALA A 169
 None
 0.94A 3sudC-4trtA:
undetectable		 3sudC-4trtA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 GLY A  47
LEU A  18
ASN A  49
GLU A  37
PHE A 120
 None
 1.07A 3vywA-4trtA:
undetectable		 3vywA-4trtA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 11 LEU A  15
ILE A  22
VAL A   6
LEU A  89
PHE A  68
 None
 0.98A 3zosA-4trtA:
undetectable
3zosB-4trtA:
undetectable		 3zosA-4trtA:
22.64
3zosB-4trtA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		3 / 3 TYR A 115
THR A  48
GLU A  37
 None
 0.80A 4df3A-4trtA:
undetectable		 4df3A-4trtA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		3 / 3 TYR A 115
THR A  48
GLU A  37
 None
 0.82A 4df3B-4trtA:
undetectable		 4df3B-4trtA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		4 / 6 LEU A 360
GLU A 277
VAL A 264
ALA A 265
 None
 1.02A 4nkvC-4trtA:
undetectable		 4nkvC-4trtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 ALA A 342
PHE A 278
LEU A 300
LEU A 287
VAL A 276
 None
 0.98A 5tudA-4trtA:
undetectable		 5tudA-4trtA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		5 / 12 GLY A 352
ARG A 174
ILE A 156
ALA A 176
ALA A 169
 None
 0.97A 6c2mD-4trtA:
undetectable		 6c2mD-4trtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 4trt DNA POLYMERASE III
SUBUNIT BETA
(Deinococcus
radiodurans) 		4 / 4 HIS A 160
VAL A 167
LEU A 158
ALA A 165
 None
 1.33A 6d8pB-4trtA:
undetectable		 6d8pB-4trtA:
19.34