SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ts6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		5 / 10 VAL A 897
THR A 900
GLY A 864
THR A 863
ALA A 862
 None
 1.28A 2coiA-4ts6A:
undetectable
2coiB-4ts6A:
undetectable		 2coiA-4ts6A:
17.02
2coiB-4ts6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		5 / 9 VAL A 897
THR A 900
GLY A 864
THR A 863
ALA A 862
 None
 1.32A 2cojA-4ts6A:
undetectable
2cojB-4ts6A:
undetectable		 2cojA-4ts6A:
17.02
2cojB-4ts6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		4 / 6 PRO A 903
LEU A 842
ALA A 878
PRO A 876
 None
 1.31A 3gv1A-4ts6A:
undetectable
3gv1C-4ts6A:
undetectable		 3gv1A-4ts6A:
23.72
3gv1C-4ts6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		4 / 6 LEU A 842
ALA A 878
PRO A 876
PRO A 903
 None
 1.33A 3gv1A-4ts6A:
undetectable
3gv1B-4ts6A:
undetectable		 3gv1A-4ts6A:
23.72
3gv1B-4ts6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		4 / 6 PRO A 903
TYR A 931
THR A 899
THR A 900
 None
 1.07A 3tneA-4ts6A:
undetectable		 3tneA-4ts6A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		4 / 6 PRO A 903
ILE A 940
VAL A 926
THR A 894
 None
 0.89A 4xe5A-4ts6A:
undetectable		 4xe5A-4ts6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		3 / 3 THR A 900
THR A 894
LEU A 842
 None
 0.59A 5m66D-4ts6A:
undetectable		 5m66D-4ts6A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2
(Drosophila
melanogaster) 		4 / 6 ARG A 841
LEU A 842
ALA A 878
GLN A 960
 None
 1.02A 6b89B-4ts6A:
undetectable		 6b89B-4ts6A:
20.72