SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tsd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 6 SER B  73
PHE B 149
PHE B  78
GLY B  76
 None
 1.13A 1icuC-4tsdB:
undetectable
1icuD-4tsdB:
undetectable		 1icuC-4tsdB:
22.71
1icuD-4tsdB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 5 PHE B  78
GLY B  76
SER B  73
PHE B 149
 None
 1.11A 1icuC-4tsdB:
undetectable
1icuD-4tsdB:
undetectable		 1icuC-4tsdB:
22.71
1icuD-4tsdB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 5 PHE B  78
GLY B  76
SER B  73
PHE B 149
 None
 1.07A 1icvA-4tsdB:
undetectable
1icvB-4tsdB:
undetectable		 1icvA-4tsdB:
22.71
1icvB-4tsdB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 4tsd HP1029
(Helicobacter
pylori) 		5 / 10 GLN B  88
GLY B   5
ALA B  99
LEU B 129
HIS B 145
 None
None
None
None
ZN  B 201 (-3.3A)
 1.15A 1jglH-4tsdB:
undetectable
1jglL-4tsdB:
undetectable		 1jglH-4tsdB:
20.99
1jglL-4tsdB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 7 LEU B  89
GLN B  88
PHE B  87
LEU B   7
 None
 1.11A 1v55C-4tsdB:
undetectable
1v55J-4tsdB:
undetectable		 1v55C-4tsdB:
20.59
1v55J-4tsdB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tsd HP1029
(Helicobacter
pylori) 		5 / 12 ILE B   3
ALA B 137
GLN B  88
PHE B  87
LEU B 136
 None
 1.11A 3dzuA-4tsdB:
undetectable		 3dzuA-4tsdB:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4tsd HP1029
(Helicobacter
pylori) 		5 / 10 PHE B  50
ALA B 165
LEU B  23
LEU B  27
VAL B  30
 None
 1.01A 3o02A-4tsdB:
undetectable
3o02B-4tsdB:
undetectable		 3o02A-4tsdB:
20.92
3o02B-4tsdB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tsd HP1029
(Helicobacter
pylori) 		3 / 3 GLN B  18
THR B  17
LEU B  54
 None
 0.74A 3ondA-4tsdB:
undetectable		 3ondA-4tsdB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tsd HP1029
(Helicobacter
pylori) 		3 / 3 GLN B  18
THR B  17
LEU B  54
 None
 0.74A 3ondB-4tsdB:
undetectable		 3ondB-4tsdB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4tsd HP1029
(Helicobacter
pylori) 		3 / 3 TYR B 157
ARG B 130
HIS B 132
 None
 1.23A 4fubA-4tsdB:
undetectable		 4fubA-4tsdB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 4tsd HP1029
(Helicobacter
pylori) 		5 / 11 LEU B  27
SER B  60
LEU B  54
LEU B  89
LEU B  23
 None
 1.44A 4or0A-4tsdB:
undetectable		 4or0A-4tsdB:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 5 GLN B  88
TYR B  65
GLU B  79
ASP B 112
 None
None
ZN  B 201 ( 3.9A)
None
 1.12A 5yf0A-4tsdB:
undetectable		 5yf0A-4tsdB:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4tsd HP1029
(Helicobacter
pylori) 		4 / 7 VAL B  85
PHE B   4
PHE B  14
LEU B  10
 None
 1.21A 6aycA-4tsdB:
undetectable		 6aycA-4tsdB:
20.11